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Folate, vitamin B12 and homocysteine status in women of childbearing age: baseline data of folic acid wheat flour fortification in Iran.
Ann Nutr Metab 2008; 53(2):143-50AN

Abstract

BACKGROUND

Folic acid fortification implemented mandatorily in many countries has been associated with significant increase in blood folate concentrations and reduction in the prevalence of neural tube defects. However, there are controversial findings on the probability of vitamin B(12) deficiency being masked in the population after folic acid fortification. Baseline data on folate and vitamin B(12) status are necessary before mandatory flour fortification is implemented.

OBJECTIVES

To assess dietary intake of folate and vitamin B(12) and to determine blood concentrations of folate, vitamin B(12) and homocysteine in women of childbearing age as baseline data regarding folic acid fortification in Iran.

METHODS

A descriptive cross-sectional survey was performed with 579 healthy women as a representative sample of the Golestan province. Fasting blood samples were taken and dietary (24-hour recall), health and sociodemographic data were collected with an interview. Serum concentrations of folate and vitamin B(12) were measured with radioimmunoassay, and plasma homocysteine concentrations were assessed by high-performance liquid chromatography with fluorescence detection.

RESULTS

Mean serum concentrations of folate and vitamin B(12) were 13.6 nmol/l (95% CI 12.8-14.4) and 194.4 pmol/l (95% CI 183.8-205.0), respectively. Inadequate serum folate levels were present in 14.3% of the women and 22.7% had serum vitamin B(12) levels below normal. Mean plasma homocysteine concentration was 12.6 micromol/l (95% CI 12.1-13.2) and hyperhomocysteinemia was observed in 38.3% of the women. Mean daily intake of folate and vitamin B(12) was 198.3 microg (95% CI 185.4-211.3) and 2.6 microg (95% CI 1.9-3.2), respectively. Folate intake from food was positively correlated with serum folate concentrations (r = 0.084, p < 0.05) and inversely correlated with plasma homocysteine concentrations (r = -0.115, p < 0.01).

CONCLUSIONS

An insufficient vitamin B(12) as well as folate status is present in Iranian women of childbearing age. The final evaluation will be carried out 18 months after flour fortification and the results will be compared with baseline data obtained from the present study in order to show the efficacy and safety of folic acid fortification in Iran.

Authors+Show Affiliations

Family Health Department, Ministry of Health and Medical Education, Tehran University of Medical Science, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18997463

Citation

Abdollahi, Z, et al. "Folate, Vitamin B12 and Homocysteine Status in Women of Childbearing Age: Baseline Data of Folic Acid Wheat Flour Fortification in Iran." Annals of Nutrition & Metabolism, vol. 53, no. 2, 2008, pp. 143-50.
Abdollahi Z, Elmadfa I, Djazayeri A, et al. Folate, vitamin B12 and homocysteine status in women of childbearing age: baseline data of folic acid wheat flour fortification in Iran. Ann Nutr Metab. 2008;53(2):143-50.
Abdollahi, Z., Elmadfa, I., Djazayeri, A., Sadeghian, S., Freisling, H., Mazandarani, F. S., & Mohamed, K. (2008). Folate, vitamin B12 and homocysteine status in women of childbearing age: baseline data of folic acid wheat flour fortification in Iran. Annals of Nutrition & Metabolism, 53(2), pp. 143-50. doi:10.1159/000170890.
Abdollahi Z, et al. Folate, Vitamin B12 and Homocysteine Status in Women of Childbearing Age: Baseline Data of Folic Acid Wheat Flour Fortification in Iran. Ann Nutr Metab. 2008;53(2):143-50. PubMed PMID: 18997463.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folate, vitamin B12 and homocysteine status in women of childbearing age: baseline data of folic acid wheat flour fortification in Iran. AU - Abdollahi,Z, AU - Elmadfa,I, AU - Djazayeri,A, AU - Sadeghian,S, AU - Freisling,H, AU - Mazandarani,F Salehi, AU - Mohamed,K, Y1 - 2008/11/10/ PY - 2008/06/13/received PY - 2008/08/27/accepted PY - 2008/11/11/pubmed PY - 2009/3/3/medline PY - 2008/11/11/entrez SP - 143 EP - 50 JF - Annals of nutrition & metabolism JO - Ann. Nutr. Metab. VL - 53 IS - 2 N2 - BACKGROUND: Folic acid fortification implemented mandatorily in many countries has been associated with significant increase in blood folate concentrations and reduction in the prevalence of neural tube defects. However, there are controversial findings on the probability of vitamin B(12) deficiency being masked in the population after folic acid fortification. Baseline data on folate and vitamin B(12) status are necessary before mandatory flour fortification is implemented. OBJECTIVES: To assess dietary intake of folate and vitamin B(12) and to determine blood concentrations of folate, vitamin B(12) and homocysteine in women of childbearing age as baseline data regarding folic acid fortification in Iran. METHODS: A descriptive cross-sectional survey was performed with 579 healthy women as a representative sample of the Golestan province. Fasting blood samples were taken and dietary (24-hour recall), health and sociodemographic data were collected with an interview. Serum concentrations of folate and vitamin B(12) were measured with radioimmunoassay, and plasma homocysteine concentrations were assessed by high-performance liquid chromatography with fluorescence detection. RESULTS: Mean serum concentrations of folate and vitamin B(12) were 13.6 nmol/l (95% CI 12.8-14.4) and 194.4 pmol/l (95% CI 183.8-205.0), respectively. Inadequate serum folate levels were present in 14.3% of the women and 22.7% had serum vitamin B(12) levels below normal. Mean plasma homocysteine concentration was 12.6 micromol/l (95% CI 12.1-13.2) and hyperhomocysteinemia was observed in 38.3% of the women. Mean daily intake of folate and vitamin B(12) was 198.3 microg (95% CI 185.4-211.3) and 2.6 microg (95% CI 1.9-3.2), respectively. Folate intake from food was positively correlated with serum folate concentrations (r = 0.084, p < 0.05) and inversely correlated with plasma homocysteine concentrations (r = -0.115, p < 0.01). CONCLUSIONS: An insufficient vitamin B(12) as well as folate status is present in Iranian women of childbearing age. The final evaluation will be carried out 18 months after flour fortification and the results will be compared with baseline data obtained from the present study in order to show the efficacy and safety of folic acid fortification in Iran. SN - 1421-9697 UR - https://www.unboundmedicine.com/medline/citation/18997463/Folate_vitamin_B12_and_homocysteine_status_in_women_of_childbearing_age:_baseline_data_of_folic_acid_wheat_flour_fortification_in_Iran_ L2 - https://www.karger.com?DOI=10.1159/000170890 DB - PRIME DP - Unbound Medicine ER -