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Hypouricemic and antioxidant activities of Allium cepa Lilliaceae and quercetin in normal and hyperuricemic rats.
Saudi Med J. 2008 Nov; 29(11):1573-9.SM

Abstract

OBJECTIVE

To evaluate the hypouricemic and antioxidant effects of Allium cepa Lilliaceae (Allium cepa L.) and quercetin in normal and hyperuricemic rats.

METHODS

The following study was conducted in the Department of Nutrition and Biochemistry, Tehran University of Medical Science, Iran, between May 2007 and March 2008. A total of 48 male Wistar rats (body weights: 180-200 g) were randomly divided into 8 equal groups including normal; normal + Allium cepa L. (5g/kg); normal + quercetin (5mg/kg); normal + allopurinol (5mg/kg); hyperuricemic; hyperuricemic + Allium cepa L. (5g/kg); hyperuricemic + quercetin (5mg/kg); hyperuricemic + allopurinol (5mg/kg) once a day for 14 days. Experimentally, hyperuricemia in rats was induced by intraperitoneal injection of potassium oxonate (250mg/kg).

RESULTS

Allium cepa L. and quercetin treatments for 14 days significantly reduced (p=0.000) the serum uric acid levels of hyperuricemic rats in a time-dependent manner. All treatments significantly inhibited hepatic xanthine oxidase/xanthine dehydrogenase activity. Allium cepa L. and quercetin treatments led also to a significant improvement in biomarkers of oxidative stress in hyperuricemic rats (p=0.000). Although the hypouricemic effect of allopurinol was much higher than that of Allium cepa L. and quercetin, it could not significantly change oxidative stress biomarkers.

CONCLUSION

These results may be responsible partly for the beneficial effects of Allium cepa L. and its major flavonoid on hyperuricemia and oxidative stress.

Authors+Show Affiliations

School of Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18998003

Citation

Haidari, Fatemeh, et al. "Hypouricemic and Antioxidant Activities of Allium Cepa Lilliaceae and Quercetin in Normal and Hyperuricemic Rats." Saudi Medical Journal, vol. 29, no. 11, 2008, pp. 1573-9.
Haidari F, Rashidi MR, Eshraghian MR, et al. Hypouricemic and antioxidant activities of Allium cepa Lilliaceae and quercetin in normal and hyperuricemic rats. Saudi Med J. 2008;29(11):1573-9.
Haidari, F., Rashidi, M. R., Eshraghian, M. R., Mahboob, S. A., Shahi, M. M., & Keshavarz, S. A. (2008). Hypouricemic and antioxidant activities of Allium cepa Lilliaceae and quercetin in normal and hyperuricemic rats. Saudi Medical Journal, 29(11), 1573-9.
Haidari F, et al. Hypouricemic and Antioxidant Activities of Allium Cepa Lilliaceae and Quercetin in Normal and Hyperuricemic Rats. Saudi Med J. 2008;29(11):1573-9. PubMed PMID: 18998003.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypouricemic and antioxidant activities of Allium cepa Lilliaceae and quercetin in normal and hyperuricemic rats. AU - Haidari,Fatemeh, AU - Rashidi,Mohammad R, AU - Eshraghian,Mohammad R, AU - Mahboob,Soltan A, AU - Shahi,Majid M, AU - Keshavarz,Seid A, PY - 2008/11/11/pubmed PY - 2009/1/31/medline PY - 2008/11/11/entrez SP - 1573 EP - 9 JF - Saudi medical journal JO - Saudi Med J VL - 29 IS - 11 N2 - OBJECTIVE: To evaluate the hypouricemic and antioxidant effects of Allium cepa Lilliaceae (Allium cepa L.) and quercetin in normal and hyperuricemic rats. METHODS: The following study was conducted in the Department of Nutrition and Biochemistry, Tehran University of Medical Science, Iran, between May 2007 and March 2008. A total of 48 male Wistar rats (body weights: 180-200 g) were randomly divided into 8 equal groups including normal; normal + Allium cepa L. (5g/kg); normal + quercetin (5mg/kg); normal + allopurinol (5mg/kg); hyperuricemic; hyperuricemic + Allium cepa L. (5g/kg); hyperuricemic + quercetin (5mg/kg); hyperuricemic + allopurinol (5mg/kg) once a day for 14 days. Experimentally, hyperuricemia in rats was induced by intraperitoneal injection of potassium oxonate (250mg/kg). RESULTS: Allium cepa L. and quercetin treatments for 14 days significantly reduced (p=0.000) the serum uric acid levels of hyperuricemic rats in a time-dependent manner. All treatments significantly inhibited hepatic xanthine oxidase/xanthine dehydrogenase activity. Allium cepa L. and quercetin treatments led also to a significant improvement in biomarkers of oxidative stress in hyperuricemic rats (p=0.000). Although the hypouricemic effect of allopurinol was much higher than that of Allium cepa L. and quercetin, it could not significantly change oxidative stress biomarkers. CONCLUSION: These results may be responsible partly for the beneficial effects of Allium cepa L. and its major flavonoid on hyperuricemia and oxidative stress. SN - 0379-5284 UR - https://www.unboundmedicine.com/medline/citation/18998003/Hypouricemic_and_antioxidant_activities_of_Allium_cepa_Lilliaceae_and_quercetin_in_normal_and_hyperuricemic_rats_ L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -