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Phosphate binders in chronic kidney disease and end-stage renal disease: a patient-centered approach.
Semin Dial. 2009 Jan-Feb; 22(1):56-63.SD

Abstract

Disorders of calcium and phosphorus metabolism are associated with significant morbidity and mortality in patients with advanced chronic kidney disease. These patients typically require oral phosphate binders to maintain phosphorus homeostasis, but the choice of which among several agents to use has been actively investigated and debated. Recent debate has been polarized between those who favor calcium-based binders for their proven efficacy and relatively low cost and those who favor sevelamer for its putative beneficial effects on inflammatory biomarkers and vascular calcification. This review summarizes the current state of the art of prescribing phosphate binders, ranging from large-scale clinical trials to focused mechanistic studies, and proposes that the available evidence does not conclusively prove the relative superiority of any one binder.

Authors+Show Affiliations

Division of Nephrology & Hypertension, Henry Ford Health System, Detroit, Michigan 48202, USA. jnovak2@hfhs.orgNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19000107

Citation

Novak, James E., and Lynda A. Szczech. "Phosphate Binders in Chronic Kidney Disease and End-stage Renal Disease: a Patient-centered Approach." Seminars in Dialysis, vol. 22, no. 1, 2009, pp. 56-63.
Novak JE, Szczech LA. Phosphate binders in chronic kidney disease and end-stage renal disease: a patient-centered approach. Semin Dial. 2009;22(1):56-63.
Novak, J. E., & Szczech, L. A. (2009). Phosphate binders in chronic kidney disease and end-stage renal disease: a patient-centered approach. Seminars in Dialysis, 22(1), 56-63. https://doi.org/10.1111/j.1525-139X.2008.00514.x
Novak JE, Szczech LA. Phosphate Binders in Chronic Kidney Disease and End-stage Renal Disease: a Patient-centered Approach. Semin Dial. 2009 Jan-Feb;22(1):56-63. PubMed PMID: 19000107.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phosphate binders in chronic kidney disease and end-stage renal disease: a patient-centered approach. AU - Novak,James E, AU - Szczech,Lynda A, Y1 - 2008/10/16/ PY - 2008/11/13/pubmed PY - 2009/8/26/medline PY - 2008/11/13/entrez SP - 56 EP - 63 JF - Seminars in dialysis JO - Semin Dial VL - 22 IS - 1 N2 - Disorders of calcium and phosphorus metabolism are associated with significant morbidity and mortality in patients with advanced chronic kidney disease. These patients typically require oral phosphate binders to maintain phosphorus homeostasis, but the choice of which among several agents to use has been actively investigated and debated. Recent debate has been polarized between those who favor calcium-based binders for their proven efficacy and relatively low cost and those who favor sevelamer for its putative beneficial effects on inflammatory biomarkers and vascular calcification. This review summarizes the current state of the art of prescribing phosphate binders, ranging from large-scale clinical trials to focused mechanistic studies, and proposes that the available evidence does not conclusively prove the relative superiority of any one binder. SN - 1525-139X UR - https://www.unboundmedicine.com/medline/citation/19000107/Phosphate_binders_in_chronic_kidney_disease_and_end_stage_renal_disease:_a_patient_centered_approach_ L2 - https://doi.org/10.1111/j.1525-139X.2008.00514.x DB - PRIME DP - Unbound Medicine ER -