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Cytotoxic prenylated xanthones from Calophyllum inophyllum.
J Asian Nat Prod Res. 2008 Sep-Oct; 10(9-10):993-7.JA

Abstract

A new prenylated xanthone (1), named caloxanthone N, together with two known constituents, gerontoxanthone C (2) and 2-hydroxyxanthone (3), was isolated from the ethanolic extract of the twigs of Calophyllum inophyllum. Their structures were completely elucidated using a combination of 1D, 2D NMR techniques (COSY, HMQC, HMBC, and ROESY) and HR-ESI-MS analyses. Compounds 1 and 2 exhibited cytotoxicity against chronic myelogenous leukemia cell line (K562) with IC50 values of 7.2 and 6.3 microg ml(- 1), respectively.

Authors+Show Affiliations

Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19003621

Citation

Xiao, Qi, et al. "Cytotoxic Prenylated Xanthones From Calophyllum Inophyllum." Journal of Asian Natural Products Research, vol. 10, no. 9-10, 2008, pp. 993-7.
Xiao Q, Zeng YB, Mei WL, et al. Cytotoxic prenylated xanthones from Calophyllum inophyllum. J Asian Nat Prod Res. 2008;10(9-10):993-7.
Xiao, Q., Zeng, Y. B., Mei, W. L., Zhao, Y. X., Deng, Y. Y., & Dai, H. F. (2008). Cytotoxic prenylated xanthones from Calophyllum inophyllum. Journal of Asian Natural Products Research, 10(9-10), 993-7. https://doi.org/10.1080/10519990802240387
Xiao Q, et al. Cytotoxic Prenylated Xanthones From Calophyllum Inophyllum. J Asian Nat Prod Res. 2008 Sep-Oct;10(9-10):993-7. PubMed PMID: 19003621.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytotoxic prenylated xanthones from Calophyllum inophyllum. AU - Xiao,Qi, AU - Zeng,Yan-Bo, AU - Mei,Wen-Li, AU - Zhao,You-Xing, AU - Deng,Yuan-Yuan, AU - Dai,Hao-Fu, PY - 2008/11/13/pubmed PY - 2009/3/25/medline PY - 2008/11/13/entrez SP - 993 EP - 7 JF - Journal of Asian natural products research JO - J Asian Nat Prod Res VL - 10 IS - 9-10 N2 - A new prenylated xanthone (1), named caloxanthone N, together with two known constituents, gerontoxanthone C (2) and 2-hydroxyxanthone (3), was isolated from the ethanolic extract of the twigs of Calophyllum inophyllum. Their structures were completely elucidated using a combination of 1D, 2D NMR techniques (COSY, HMQC, HMBC, and ROESY) and HR-ESI-MS analyses. Compounds 1 and 2 exhibited cytotoxicity against chronic myelogenous leukemia cell line (K562) with IC50 values of 7.2 and 6.3 microg ml(- 1), respectively. SN - 1028-6020 UR - https://www.unboundmedicine.com/medline/citation/19003621/Cytotoxic_prenylated_xanthones_from_Calophyllum_inophyllum_ L2 - https://www.tandfonline.com/doi/full/10.1080/10519990802240387 DB - PRIME DP - Unbound Medicine ER -