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[Influenza pandemic: hypotheses and facts].

Abstract

Data on influenza pandemics as well as on the characteristics of influenza viruses, which caused pandemicsin 1918, 1957, 1968, and 1977 are presented. Mechanisms of pandemic influenza virus strains evolving, including mutations resulting in increase of virulence, as well as possibility of human and avian influenza viruses reassortment process as the source of pandemic strains are discussed. Mechanisms of transformation of mildly virulent influenza virus strains to highly virulent, which can cause epizootics, are reviewed. Genes and proteins determining species specificity of avian influenza viruses as well as possible emergence of influenza pandemic caused by H5N1 strain are discussed. Suggestion of low probability of such event is expressed.

Authors

Source

MeSH

Animals
Disease Outbreaks
Global Health
History, 20th Century
History, 21st Century
Humans
Influenza A Virus, H5N1 Subtype
Influenza A virus
Influenza, Human
Mutation
Species Specificity
Virulence

Pub Type(s)

English Abstract
Historical Article
Journal Article
Review

Language

rus

PubMed ID

19004295

Citation

Gendon, Iu Z.. "[Influenza Pandemic: Hypotheses and Facts]." Zhurnal Mikrobiologii, Epidemiologii, I Immunobiologii, 2008, pp. 109-18.
Gendon IuZ. [Influenza pandemic: hypotheses and facts]. Zh Mikrobiol Epidemiol Immunobiol. 2008.
Gendon, I. u. Z. (2008). [Influenza pandemic: hypotheses and facts]. Zhurnal Mikrobiologii, Epidemiologii, I Immunobiologii, (5), pp. 109-18.
Gendon IuZ. [Influenza Pandemic: Hypotheses and Facts]. Zh Mikrobiol Epidemiol Immunobiol. 2008;(5)109-18. PubMed PMID: 19004295.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Influenza pandemic: hypotheses and facts]. A1 - Gendon,Iu Z, PY - 2008/11/14/pubmed PY - 2009/1/7/medline PY - 2008/11/14/entrez SP - 109 EP - 18 JF - Zhurnal mikrobiologii, epidemiologii, i immunobiologii JO - Zh. Mikrobiol. Epidemiol. Immunobiol. IS - 5 N2 - Data on influenza pandemics as well as on the characteristics of influenza viruses, which caused pandemicsin 1918, 1957, 1968, and 1977 are presented. Mechanisms of pandemic influenza virus strains evolving, including mutations resulting in increase of virulence, as well as possibility of human and avian influenza viruses reassortment process as the source of pandemic strains are discussed. Mechanisms of transformation of mildly virulent influenza virus strains to highly virulent, which can cause epizootics, are reviewed. Genes and proteins determining species specificity of avian influenza viruses as well as possible emergence of influenza pandemic caused by H5N1 strain are discussed. Suggestion of low probability of such event is expressed. SN - 0372-9311 UR - https://www.unboundmedicine.com/medline/citation/19004295/[Influenza_pandemic:_hypotheses_and_facts]_ L2 - https://medlineplus.gov/flu.html DB - PRIME DP - Unbound Medicine ER -