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Nedd4L expression is downregulated in prostate cancer compared to benign prostatic hyperplasia.
Eur J Surg Oncol. 2009 May; 35(5):527-31.EJ

Abstract

AIMS

To characterize aspects of Nedd4L in prostate cancer (PC) by assessing its expression in hyperplastic and malignant prostate tissue, and to correlate findings with PC histologic grade.

MATERIALS AND METHODS

Radical prostatectomy (RP) specimens from 56 patients with clinically localized PC, and benign prostatic hyperplasia (BPH) transurethral resection specimens from 31 patients, were assessed for Nedd4L expression using immunohistochemistry.

RESULTS

Nedd4L (P<0.001) expressions were significantly decreased in PC compared to benign prostate tissue. Furthermore, downregulation of Nedd4L (P<0.05) expression correlated with increasing Gleason score.

CONCLUSIONS

These data suggest that prostate cancer cells in vivo may need Nedd4L expression to regulate TGF-beta1 signaling, and that Nedd4L expression might be involved in prostate cancer development.

Authors+Show Affiliations

Department of Urology, Shanghai Jiaotong University Affiliated 6th People's Hospital, Shanghai Jiaotong University, Shanghai, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19004604

Citation

Hu, X Y., et al. "Nedd4L Expression Is Downregulated in Prostate Cancer Compared to Benign Prostatic Hyperplasia." European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, vol. 35, no. 5, 2009, pp. 527-31.
Hu XY, Xu YM, Fu Q, et al. Nedd4L expression is downregulated in prostate cancer compared to benign prostatic hyperplasia. Eur J Surg Oncol. 2009;35(5):527-31.
Hu, X. Y., Xu, Y. M., Fu, Q., Yu, J. J., & Huang, J. (2009). Nedd4L expression is downregulated in prostate cancer compared to benign prostatic hyperplasia. European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 35(5), 527-31. https://doi.org/10.1016/j.ejso.2008.09.015
Hu XY, et al. Nedd4L Expression Is Downregulated in Prostate Cancer Compared to Benign Prostatic Hyperplasia. Eur J Surg Oncol. 2009;35(5):527-31. PubMed PMID: 19004604.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nedd4L expression is downregulated in prostate cancer compared to benign prostatic hyperplasia. AU - Hu,X Y, AU - Xu,Y M, AU - Fu,Q, AU - Yu,J J, AU - Huang,J, Y1 - 2008/11/11/ PY - 2008/06/24/received PY - 2008/09/06/revised PY - 2008/09/30/accepted PY - 2008/11/14/pubmed PY - 2009/5/6/medline PY - 2008/11/14/entrez SP - 527 EP - 31 JF - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology JO - Eur J Surg Oncol VL - 35 IS - 5 N2 - AIMS: To characterize aspects of Nedd4L in prostate cancer (PC) by assessing its expression in hyperplastic and malignant prostate tissue, and to correlate findings with PC histologic grade. MATERIALS AND METHODS: Radical prostatectomy (RP) specimens from 56 patients with clinically localized PC, and benign prostatic hyperplasia (BPH) transurethral resection specimens from 31 patients, were assessed for Nedd4L expression using immunohistochemistry. RESULTS: Nedd4L (P<0.001) expressions were significantly decreased in PC compared to benign prostate tissue. Furthermore, downregulation of Nedd4L (P<0.05) expression correlated with increasing Gleason score. CONCLUSIONS: These data suggest that prostate cancer cells in vivo may need Nedd4L expression to regulate TGF-beta1 signaling, and that Nedd4L expression might be involved in prostate cancer development. SN - 1532-2157 UR - https://www.unboundmedicine.com/medline/citation/19004604/Nedd4L_expression_is_downregulated_in_prostate_cancer_compared_to_benign_prostatic_hyperplasia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0748-7983(08)01774-5 DB - PRIME DP - Unbound Medicine ER -