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Bowel movement frequency in late-life and substantia nigra neuron density at death.
Mov Disord. 2009 Feb 15; 24(3):371-6.MD

Abstract

Constipation is associated with future risk of Parkinson's disease (PD) and with incidental Lewy bodies (LB) in the locus ceruleus or substantia nigra (SN). Our purpose is to examine the independent association between bowel movement frequency in late-life and postmortem SN neuron density. Bowel movement frequency was assessed in the Honolulu-Asia Aging Study from 1991 to 1993 in 414 men aged 71 to 93 years with later postmortem evaluations. Brains were examined for LB in the SN and locus ceruleus and neurons were counted in four quadrants from a transverse section of SN. In nonsmokers, neuron densities (counts/mm(2)) for men with >1, 1, and <1 bowel movement daily were 18.5, 18.8, 10.1 (P < 0.001) for dorsomedial; 15.3, 16.4, 10.2 (P < 0.03) for ventromedial; and 18.6, 18.3, 10.9 (P = 0.011) for ventrolateral quadrants. Relationships were not significant in the dorsolateral quadrant or in any quadrant among smokers. After adjustment for age, time to death, coffee drinking, tricep skinfold thickness, excessive daytime sleepiness, cognitive function, PD, and incidental LB, density ratios in nonsmokers with 1 or more bowel movement(s) daily were significantly higher compared to those with <1 daily. Constipation is associated with low SN neuron density independent of the presence of LB.

Authors+Show Affiliations

Pacific Health Research Institute, Honolulu, Hawaii, USA. hpetrovitch@phrihawaii.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

19006191

Citation

Petrovitch, Helen, et al. "Bowel Movement Frequency in Late-life and Substantia Nigra Neuron Density at Death." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 24, no. 3, 2009, pp. 371-6.
Petrovitch H, Abbott RD, Ross GW, et al. Bowel movement frequency in late-life and substantia nigra neuron density at death. Mov Disord. 2009;24(3):371-6.
Petrovitch, H., Abbott, R. D., Ross, G. W., Nelson, J., Masaki, K. H., Tanner, C. M., Launer, L. J., & White, L. R. (2009). Bowel movement frequency in late-life and substantia nigra neuron density at death. Movement Disorders : Official Journal of the Movement Disorder Society, 24(3), 371-6. https://doi.org/10.1002/mds.22360
Petrovitch H, et al. Bowel Movement Frequency in Late-life and Substantia Nigra Neuron Density at Death. Mov Disord. 2009 Feb 15;24(3):371-6. PubMed PMID: 19006191.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bowel movement frequency in late-life and substantia nigra neuron density at death. AU - Petrovitch,Helen, AU - Abbott,Robert D, AU - Ross,G Webster, AU - Nelson,James, AU - Masaki,Kamal H, AU - Tanner,Caroline M, AU - Launer,Lenore J, AU - White,Lon R, PY - 2008/11/14/pubmed PY - 2009/7/28/medline PY - 2008/11/14/entrez SP - 371 EP - 6 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 24 IS - 3 N2 - Constipation is associated with future risk of Parkinson's disease (PD) and with incidental Lewy bodies (LB) in the locus ceruleus or substantia nigra (SN). Our purpose is to examine the independent association between bowel movement frequency in late-life and postmortem SN neuron density. Bowel movement frequency was assessed in the Honolulu-Asia Aging Study from 1991 to 1993 in 414 men aged 71 to 93 years with later postmortem evaluations. Brains were examined for LB in the SN and locus ceruleus and neurons were counted in four quadrants from a transverse section of SN. In nonsmokers, neuron densities (counts/mm(2)) for men with >1, 1, and <1 bowel movement daily were 18.5, 18.8, 10.1 (P < 0.001) for dorsomedial; 15.3, 16.4, 10.2 (P < 0.03) for ventromedial; and 18.6, 18.3, 10.9 (P = 0.011) for ventrolateral quadrants. Relationships were not significant in the dorsolateral quadrant or in any quadrant among smokers. After adjustment for age, time to death, coffee drinking, tricep skinfold thickness, excessive daytime sleepiness, cognitive function, PD, and incidental LB, density ratios in nonsmokers with 1 or more bowel movement(s) daily were significantly higher compared to those with <1 daily. Constipation is associated with low SN neuron density independent of the presence of LB. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/19006191/Bowel_movement_frequency_in_late_life_and_substantia_nigra_neuron_density_at_death_ L2 - https://doi.org/10.1002/mds.22360 DB - PRIME DP - Unbound Medicine ER -