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[Cytokine profile and level of antibodies after administration of split-vaccine against influenza to adults].
Zh Mikrobiol Epidemiol Immunobiol 2008 Sep-Oct; (5):57-61ZM

Abstract

Serum concentrations of cytokines (IFN-gamma, TNF-alpha, IL-2, IL-4, IL-6, IL-8) and antibody levels to influenza virus antigens were studied in adults vaccinated with split-vaccine against influenza. Analysis of antibody titers 21 days after vaccination compared with baseline levels revealed high immunogenicity of vaccine in terms of mean geometric titers increase as well as sufficient levels of seroprotection and seroconversion. Study of cytokine profile showed absence of significant changes of IFN-gamma, TNF-alpha, IL-2, IL-4 levels and considerable variability of IL-6 and IL-8 baseline levels as well as their dynamics after vaccination. Direct correlation between IL-6 and IL-8 levels was observed during whole period post-immunization. Inverse correlation between IFN-gamma and fold increase of antibody level was established which can be used as prognostic criterion of influenza prevention effectiveness.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
English Abstract
Journal Article

Language

rus

PubMed ID

19006832

Citation

Bogomolov, S V., et al. "[Cytokine Profile and Level of Antibodies After Administration of Split-vaccine Against Influenza to Adults]." Zhurnal Mikrobiologii, Epidemiologii, I Immunobiologii, 2008, pp. 57-61.
Bogomolov SV, Zhirova SN, Kostinov MP. [Cytokine profile and level of antibodies after administration of split-vaccine against influenza to adults]. Zh Mikrobiol Epidemiol Immunobiol. 2008.
Bogomolov, S. V., Zhirova, S. N., & Kostinov, M. P. (2008). [Cytokine profile and level of antibodies after administration of split-vaccine against influenza to adults]. Zhurnal Mikrobiologii, Epidemiologii, I Immunobiologii, (5), pp. 57-61.
Bogomolov SV, Zhirova SN, Kostinov MP. [Cytokine Profile and Level of Antibodies After Administration of Split-vaccine Against Influenza to Adults]. Zh Mikrobiol Epidemiol Immunobiol. 2008;(5)57-61. PubMed PMID: 19006832.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Cytokine profile and level of antibodies after administration of split-vaccine against influenza to adults]. AU - Bogomolov,S V, AU - Zhirova,S N, AU - Kostinov,M P, PY - 2008/11/14/pubmed PY - 2009/1/7/medline PY - 2008/11/14/entrez SP - 57 EP - 61 JF - Zhurnal mikrobiologii, epidemiologii, i immunobiologii JO - Zh. Mikrobiol. Epidemiol. Immunobiol. IS - 5 N2 - Serum concentrations of cytokines (IFN-gamma, TNF-alpha, IL-2, IL-4, IL-6, IL-8) and antibody levels to influenza virus antigens were studied in adults vaccinated with split-vaccine against influenza. Analysis of antibody titers 21 days after vaccination compared with baseline levels revealed high immunogenicity of vaccine in terms of mean geometric titers increase as well as sufficient levels of seroprotection and seroconversion. Study of cytokine profile showed absence of significant changes of IFN-gamma, TNF-alpha, IL-2, IL-4 levels and considerable variability of IL-6 and IL-8 baseline levels as well as their dynamics after vaccination. Direct correlation between IL-6 and IL-8 levels was observed during whole period post-immunization. Inverse correlation between IFN-gamma and fold increase of antibody level was established which can be used as prognostic criterion of influenza prevention effectiveness. SN - 0372-9311 UR - https://www.unboundmedicine.com/medline/citation/19006832/[Cytokine_profile_and_level_of_antibodies_after_administration_of_split_vaccine_against_influenza_to_adults]_ L2 - https://medlineplus.gov/flu.html DB - PRIME DP - Unbound Medicine ER -