[Cytokine profile and level of antibodies after administration of split-vaccine against influenza to adults].Zh Mikrobiol Epidemiol Immunobiol 2008 Sep-Oct; (5):57-61ZM
Serum concentrations of cytokines (IFN-gamma, TNF-alpha, IL-2, IL-4, IL-6, IL-8) and antibody levels to influenza virus antigens were studied in adults vaccinated with split-vaccine against influenza. Analysis of antibody titers 21 days after vaccination compared with baseline levels revealed high immunogenicity of vaccine in terms of mean geometric titers increase as well as sufficient levels of seroprotection and seroconversion. Study of cytokine profile showed absence of significant changes of IFN-gamma, TNF-alpha, IL-2, IL-4 levels and considerable variability of IL-6 and IL-8 baseline levels as well as their dynamics after vaccination. Direct correlation between IL-6 and IL-8 levels was observed during whole period post-immunization. Inverse correlation between IFN-gamma and fold increase of antibody level was established which can be used as prognostic criterion of influenza prevention effectiveness.