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Propiverine vs oxybutynin for treating neurogenic detrusor overactivity in children and adolescents: results of a multicentre observational cohort study.
BJU Int. 2009 Mar; 103(6):776-81.BI

Abstract

OBJECTIVE

To compare, in a retrospective observational cohort study, the efficacy, tolerability, safety and clinical effectiveness of propiverine and oxybutynin in children and adolescents with neurogenic detrusor overactivity (NDO).

PATIENTS AND METHODS

In all, 255 children and adolescents (aged 1-18 years) with NDO (199 myelomeningocele, 46 spinal cord injury, 10 other diagnoses) were enrolled at 14 study centres. To evaluate the efficacy of propiverine and oxybutynin, urodynamic and clinical variables were assessed before and after at least 12 month of the antimuscarinic agents administered at variable doses.

RESULTS

In all, 127 patients given propiverine and 128 given oxybutynin were enrolled. The primary efficacy outcome, i.e. reductions in urodynamically assessed individual maximum detrusor pressure (P(detmax)), was assumed to indicate success in 74.2% of those on propiverine vs 49.6% on oxybutynin. The mean P(detmax) was significantly reduced during treatment, from 59.8 to 36.7 cmH(2)O in the propiverine and from 65.2 to 54.9 cmH(2)O in the oxybutynin groups. The mean maximum cystometric bladder capacity increased from 146 to 242 mL in the propiverine and from 222 to 310 mL in the oxybutynin group. Propiverine was better tolerated than oxybutynin, having fewer adverse drug reactions (9.4% vs 17.2%, odds ratio 2.04), and for its severity grades and premature treatment termination (none vs 11 cases).

CONCLUSION

In this non-interventional study, reflecting 'real-life' clinical practice, comparing the efficacy, tolerability and safety of propiverine and oxybutynin in children and adolescents with NDO, propiverine was at least as effective as oxybutynin, but better tolerated, resulting in superior clinical effectiveness than for oxybutynin.

Authors+Show Affiliations

Neuro-Urology Unit, University Hospital Innsbruck, Austria. helmut.madersbacher@tilak.atNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19007380

Citation

Madersbacher, Helmut, et al. "Propiverine Vs Oxybutynin for Treating Neurogenic Detrusor Overactivity in Children and Adolescents: Results of a Multicentre Observational Cohort Study." BJU International, vol. 103, no. 6, 2009, pp. 776-81.
Madersbacher H, Mürtz G, Alloussi S, et al. Propiverine vs oxybutynin for treating neurogenic detrusor overactivity in children and adolescents: results of a multicentre observational cohort study. BJU Int. 2009;103(6):776-81.
Madersbacher, H., Mürtz, G., Alloussi, S., Domurath, B., Henne, T., Körner, I., Niedeggen, A., Nounla, J., Pannek, J., Schulte-Baukloh, H., Schultz-Lampel, D., Bock, P., & Strugala, G. (2009). Propiverine vs oxybutynin for treating neurogenic detrusor overactivity in children and adolescents: results of a multicentre observational cohort study. BJU International, 103(6), 776-81. https://doi.org/10.1111/j.1464-410X.2008.08093.x
Madersbacher H, et al. Propiverine Vs Oxybutynin for Treating Neurogenic Detrusor Overactivity in Children and Adolescents: Results of a Multicentre Observational Cohort Study. BJU Int. 2009;103(6):776-81. PubMed PMID: 19007380.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Propiverine vs oxybutynin for treating neurogenic detrusor overactivity in children and adolescents: results of a multicentre observational cohort study. AU - Madersbacher,Helmut, AU - Mürtz,Gerd, AU - Alloussi,Schahnaz, AU - Domurath,Burghard, AU - Henne,Thomas, AU - Körner,Iris, AU - Niedeggen,Andreas, AU - Nounla,Joseph, AU - Pannek,Jürgen, AU - Schulte-Baukloh,Heinrich, AU - Schultz-Lampel,Daniela, AU - Bock,Paul, AU - Strugala,Gerhard, Y1 - 2008/10/24/ PY - 2008/11/15/pubmed PY - 2009/4/10/medline PY - 2008/11/15/entrez SP - 776 EP - 81 JF - BJU international JO - BJU Int VL - 103 IS - 6 N2 - OBJECTIVE: To compare, in a retrospective observational cohort study, the efficacy, tolerability, safety and clinical effectiveness of propiverine and oxybutynin in children and adolescents with neurogenic detrusor overactivity (NDO). PATIENTS AND METHODS: In all, 255 children and adolescents (aged 1-18 years) with NDO (199 myelomeningocele, 46 spinal cord injury, 10 other diagnoses) were enrolled at 14 study centres. To evaluate the efficacy of propiverine and oxybutynin, urodynamic and clinical variables were assessed before and after at least 12 month of the antimuscarinic agents administered at variable doses. RESULTS: In all, 127 patients given propiverine and 128 given oxybutynin were enrolled. The primary efficacy outcome, i.e. reductions in urodynamically assessed individual maximum detrusor pressure (P(detmax)), was assumed to indicate success in 74.2% of those on propiverine vs 49.6% on oxybutynin. The mean P(detmax) was significantly reduced during treatment, from 59.8 to 36.7 cmH(2)O in the propiverine and from 65.2 to 54.9 cmH(2)O in the oxybutynin groups. The mean maximum cystometric bladder capacity increased from 146 to 242 mL in the propiverine and from 222 to 310 mL in the oxybutynin group. Propiverine was better tolerated than oxybutynin, having fewer adverse drug reactions (9.4% vs 17.2%, odds ratio 2.04), and for its severity grades and premature treatment termination (none vs 11 cases). CONCLUSION: In this non-interventional study, reflecting 'real-life' clinical practice, comparing the efficacy, tolerability and safety of propiverine and oxybutynin in children and adolescents with NDO, propiverine was at least as effective as oxybutynin, but better tolerated, resulting in superior clinical effectiveness than for oxybutynin. SN - 1464-410X UR - https://www.unboundmedicine.com/medline/citation/19007380/Propiverine_vs_oxybutynin_for_treating_neurogenic_detrusor_overactivity_in_children_and_adolescents:_results_of_a_multicentre_observational_cohort_study_ L2 - https://doi.org/10.1111/j.1464-410X.2008.08093.x DB - PRIME DP - Unbound Medicine ER -