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Urinary elimination of 11-nor-9-carboxy-delta9-tetrahydrocannnabinol in cannabis users during continuously monitored abstinence.
J Anal Toxicol 2008; 32(8):562-9JA

Abstract

The time course of 11-nor-9-carboxy-Delta9-tetrahydrocannnabinol (THCCOOH) elimination in urine was characterized in 60 cannabis users during 24 h monitored abstinence on a closed research unit for up to 30 days. Six thousand, one hundred fifty-eight individual urine specimens were screened by immunoassay with values > or = 50 ng/mL classified as positive. Urine specimens were confirmed for THCCOOH by gas chromatography-mass spectrometry following base hydrolysis and liquid-liquid or solid-phase extraction. In 60%, the maximum creatinine normalized concentration occurred in the first urine specimen; in 40%, peaks occurred as long as 2.9 days after admission. Data were divided into three groups, 0-50, 51-150, and > 150 ng/mg, based on the creatinine corrected initial THCCOOH concentration. There were statistically significant correlations between groups and number of days until first negative and last positive urine specimens; mean number of days were 0.6 and 4.3, 3.2 and 9.7, and 4.7 and 15.4 days, respectively, for the three groups. These data provide guidelines for interpreting urine cannabinoid test results and suggest appropriate detection windows for differentiating new cannabis use from residual drug excretion.

Authors+Show Affiliations

Chemistry and Drug Metabolism Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Rockville, Maryland, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19007504

Citation

Goodwin, Robert S., et al. "Urinary Elimination of 11-nor-9-carboxy-delta9-tetrahydrocannnabinol in Cannabis Users During Continuously Monitored Abstinence." Journal of Analytical Toxicology, vol. 32, no. 8, 2008, pp. 562-9.
Goodwin RS, Darwin WD, Chiang CN, et al. Urinary elimination of 11-nor-9-carboxy-delta9-tetrahydrocannnabinol in cannabis users during continuously monitored abstinence. J Anal Toxicol. 2008;32(8):562-9.
Goodwin, R. S., Darwin, W. D., Chiang, C. N., Shih, M., Li, S. H., & Huestis, M. A. (2008). Urinary elimination of 11-nor-9-carboxy-delta9-tetrahydrocannnabinol in cannabis users during continuously monitored abstinence. Journal of Analytical Toxicology, 32(8), pp. 562-9.
Goodwin RS, et al. Urinary Elimination of 11-nor-9-carboxy-delta9-tetrahydrocannnabinol in Cannabis Users During Continuously Monitored Abstinence. J Anal Toxicol. 2008;32(8):562-9. PubMed PMID: 19007504.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urinary elimination of 11-nor-9-carboxy-delta9-tetrahydrocannnabinol in cannabis users during continuously monitored abstinence. AU - Goodwin,Robert S, AU - Darwin,William D, AU - Chiang,C Nora, AU - Shih,Ming, AU - Li,Shou-Hua, AU - Huestis,Marilyn A, PY - 2008/11/15/pubmed PY - 2008/12/17/medline PY - 2008/11/15/entrez SP - 562 EP - 9 JF - Journal of analytical toxicology JO - J Anal Toxicol VL - 32 IS - 8 N2 - The time course of 11-nor-9-carboxy-Delta9-tetrahydrocannnabinol (THCCOOH) elimination in urine was characterized in 60 cannabis users during 24 h monitored abstinence on a closed research unit for up to 30 days. Six thousand, one hundred fifty-eight individual urine specimens were screened by immunoassay with values > or = 50 ng/mL classified as positive. Urine specimens were confirmed for THCCOOH by gas chromatography-mass spectrometry following base hydrolysis and liquid-liquid or solid-phase extraction. In 60%, the maximum creatinine normalized concentration occurred in the first urine specimen; in 40%, peaks occurred as long as 2.9 days after admission. Data were divided into three groups, 0-50, 51-150, and > 150 ng/mg, based on the creatinine corrected initial THCCOOH concentration. There were statistically significant correlations between groups and number of days until first negative and last positive urine specimens; mean number of days were 0.6 and 4.3, 3.2 and 9.7, and 4.7 and 15.4 days, respectively, for the three groups. These data provide guidelines for interpreting urine cannabinoid test results and suggest appropriate detection windows for differentiating new cannabis use from residual drug excretion. SN - 0146-4760 UR - https://www.unboundmedicine.com/medline/citation/19007504/abstract/Urinary_elimination_of_11_nor_9_carboxy_delta9_tetrahydrocannnabinol_in_cannabis_users_during_continuously_monitored_abstinence L2 - https://academic.oup.com/jat/article-lookup/doi/10.1093/jat/32.8.562 DB - PRIME DP - Unbound Medicine ER -