Tags

Type your tag names separated by a space and hit enter

Paeonol attenuates neurotoxicity and ameliorates cognitive impairment induced by d-galactose in ICR mice.
J Neurol Sci. 2009 Feb 15; 277(1-2):58-64.JN

Abstract

In the present study, we examined the supplementation of paeonol extracted from Moutan cortex of Paeonia suffruticosa Andrews (MC) or the root of Paeonia lactiflora Pall (PL) on reducing oxidative stress, cognitive impairment and neurotoxicity in d-galactose (D-gal)-induced aging mice. The ICR mice were subcutaneously injected with D-gal (50 mg/(kg day)) for 60 days and administered with paeonol (50, 100 mg/(kg day)) simultaneously. The results showed that paeonol significantly improved the learning and memory ability in Morris water maze test and step-down passive avoidance test in D-gal-treated mice. Further investigation showed that the effect of paeonol on improvement of cognitive deficit was related to its ability to inhibit the biochemical changes in brains of D-gal-treated mice. Paeonol increased acetylcholine (Ach) and glutathione (GSH) levels, restored superoxide dismutase (SOD) and Na(+), K(+)-adenosine triphosphatase (Na(+), K(+)-ATPase) activities, but decreased cholinesterase AChe activity and malondialdehyde (MDA) level in D-gal-treated mice. Furthermore, paeonol ameliorated neuronal damage in both hippocampus and temporal cortex in D-gal-treated mice. These results suggest that paeonol possesses anti-aging efficacy and may have potential in treatment of neurodegenerative diseases.

Authors+Show Affiliations

Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, 210038, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19007942

Citation

Zhong, Shu-Zhi, et al. "Paeonol Attenuates Neurotoxicity and Ameliorates Cognitive Impairment Induced By D-galactose in ICR Mice." Journal of the Neurological Sciences, vol. 277, no. 1-2, 2009, pp. 58-64.
Zhong SZ, Ge QH, Qu R, et al. Paeonol attenuates neurotoxicity and ameliorates cognitive impairment induced by d-galactose in ICR mice. J Neurol Sci. 2009;277(1-2):58-64.
Zhong, S. Z., Ge, Q. H., Qu, R., Li, Q., & Ma, S. P. (2009). Paeonol attenuates neurotoxicity and ameliorates cognitive impairment induced by d-galactose in ICR mice. Journal of the Neurological Sciences, 277(1-2), 58-64. https://doi.org/10.1016/j.jns.2008.10.008
Zhong SZ, et al. Paeonol Attenuates Neurotoxicity and Ameliorates Cognitive Impairment Induced By D-galactose in ICR Mice. J Neurol Sci. 2009 Feb 15;277(1-2):58-64. PubMed PMID: 19007942.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Paeonol attenuates neurotoxicity and ameliorates cognitive impairment induced by d-galactose in ICR mice. AU - Zhong,Shu-Zhi, AU - Ge,Qing-Hua, AU - Qu,Rong, AU - Li,Qiao, AU - Ma,Shi-Ping, Y1 - 2008/11/12/ PY - 2008/06/27/received PY - 2008/10/06/revised PY - 2008/10/08/accepted PY - 2008/11/15/pubmed PY - 2009/4/3/medline PY - 2008/11/15/entrez SP - 58 EP - 64 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 277 IS - 1-2 N2 - In the present study, we examined the supplementation of paeonol extracted from Moutan cortex of Paeonia suffruticosa Andrews (MC) or the root of Paeonia lactiflora Pall (PL) on reducing oxidative stress, cognitive impairment and neurotoxicity in d-galactose (D-gal)-induced aging mice. The ICR mice were subcutaneously injected with D-gal (50 mg/(kg day)) for 60 days and administered with paeonol (50, 100 mg/(kg day)) simultaneously. The results showed that paeonol significantly improved the learning and memory ability in Morris water maze test and step-down passive avoidance test in D-gal-treated mice. Further investigation showed that the effect of paeonol on improvement of cognitive deficit was related to its ability to inhibit the biochemical changes in brains of D-gal-treated mice. Paeonol increased acetylcholine (Ach) and glutathione (GSH) levels, restored superoxide dismutase (SOD) and Na(+), K(+)-adenosine triphosphatase (Na(+), K(+)-ATPase) activities, but decreased cholinesterase AChe activity and malondialdehyde (MDA) level in D-gal-treated mice. Furthermore, paeonol ameliorated neuronal damage in both hippocampus and temporal cortex in D-gal-treated mice. These results suggest that paeonol possesses anti-aging efficacy and may have potential in treatment of neurodegenerative diseases. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/19007942/Paeonol_attenuates_neurotoxicity_and_ameliorates_cognitive_impairment_induced_by_d_galactose_in_ICR_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(08)00515-7 DB - PRIME DP - Unbound Medicine ER -