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The relationship of bulimia and anorexia nervosa with bipolar disorder and its temperamental foundations.
J Affect Disord. 2009 Jun; 115(3):309-14.JA

Abstract

BACKGROUND

Earlier studies have suggested a relationship between bipolar disorder (BP) and eating disorders (ED), more specifically, bulimia nervosa (BN) and bipolar II disorder (BP-II). In the present report we extend this relationship to broader definitions of bipolarity.

METHODS

Semi-structured interview of 201 patients with DSM-IV criteria for major affective disorders combined with Akiskal and Mallya criteria for Affective temperaments. To diagnose lifetime comorbid eating disorders DSM-IV criteria for eating disorders (Bulimia Nervosa, BN, Anorexia, AN) were used.

RESULTS

33 patients had an eating disorder. When compared to patients without ED the patients with ED had a higher prevalence of bipolar disorders. Using strict DSM-IV criteria, this association was only significant for BN (OR) 4.5 (95% CI 1.1-17.6). When using a broader index of bipolarity including patients having affective temperaments, a significant relation was found for BN (OR) 9.1 (95% CI 1.1-73.6), and for patients with a lifetime history of both BN and AN (OR) 8.6 (95% CI 1.1-70.2).We also found patients with ED to have a significantly higher prevalence of affective temperaments, an earlier onset of major affective disorder and to have more depressive episodes.

LIMITATIONS

Non-blind evaluation of diagnosis for mood, eating disorders and affective temperaments.

CONCLUSION

In line with previous reports we describe an association between bulimia nervosa and bipolar disorder. Furthermore we report a relationship between lifetime bulimia and anorexia and cyclothymic and related affective temperaments.

Authors+Show Affiliations

Department of Clinical Psychiatry Risskov, Aarhus University Hospital, Denmark; International Mood Center, University of California, La Jolla, CA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19007998

Citation

Lunde, Anna V., et al. "The Relationship of Bulimia and Anorexia Nervosa With Bipolar Disorder and Its Temperamental Foundations." Journal of Affective Disorders, vol. 115, no. 3, 2009, pp. 309-14.
Lunde AV, Fasmer OB, Akiskal KK, et al. The relationship of bulimia and anorexia nervosa with bipolar disorder and its temperamental foundations. J Affect Disord. 2009;115(3):309-14.
Lunde, A. V., Fasmer, O. B., Akiskal, K. K., Akiskal, H. S., & Oedegaard, K. J. (2009). The relationship of bulimia and anorexia nervosa with bipolar disorder and its temperamental foundations. Journal of Affective Disorders, 115(3), 309-14. https://doi.org/10.1016/j.jad.2008.10.012
Lunde AV, et al. The Relationship of Bulimia and Anorexia Nervosa With Bipolar Disorder and Its Temperamental Foundations. J Affect Disord. 2009;115(3):309-14. PubMed PMID: 19007998.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship of bulimia and anorexia nervosa with bipolar disorder and its temperamental foundations. AU - Lunde,Anna V, AU - Fasmer,Ole B, AU - Akiskal,Kareen K, AU - Akiskal,Hagop S, AU - Oedegaard,Ketil J, Y1 - 2008/11/12/ PY - 2008/06/16/received PY - 2008/09/30/revised PY - 2008/10/04/accepted PY - 2008/11/15/pubmed PY - 2009/8/12/medline PY - 2008/11/15/entrez SP - 309 EP - 14 JF - Journal of affective disorders JO - J Affect Disord VL - 115 IS - 3 N2 - BACKGROUND: Earlier studies have suggested a relationship between bipolar disorder (BP) and eating disorders (ED), more specifically, bulimia nervosa (BN) and bipolar II disorder (BP-II). In the present report we extend this relationship to broader definitions of bipolarity. METHODS: Semi-structured interview of 201 patients with DSM-IV criteria for major affective disorders combined with Akiskal and Mallya criteria for Affective temperaments. To diagnose lifetime comorbid eating disorders DSM-IV criteria for eating disorders (Bulimia Nervosa, BN, Anorexia, AN) were used. RESULTS: 33 patients had an eating disorder. When compared to patients without ED the patients with ED had a higher prevalence of bipolar disorders. Using strict DSM-IV criteria, this association was only significant for BN (OR) 4.5 (95% CI 1.1-17.6). When using a broader index of bipolarity including patients having affective temperaments, a significant relation was found for BN (OR) 9.1 (95% CI 1.1-73.6), and for patients with a lifetime history of both BN and AN (OR) 8.6 (95% CI 1.1-70.2).We also found patients with ED to have a significantly higher prevalence of affective temperaments, an earlier onset of major affective disorder and to have more depressive episodes. LIMITATIONS: Non-blind evaluation of diagnosis for mood, eating disorders and affective temperaments. CONCLUSION: In line with previous reports we describe an association between bulimia nervosa and bipolar disorder. Furthermore we report a relationship between lifetime bulimia and anorexia and cyclothymic and related affective temperaments. SN - 1573-2517 UR - https://www.unboundmedicine.com/medline/citation/19007998/The_relationship_of_bulimia_and_anorexia_nervosa_with_bipolar_disorder_and_its_temperamental_foundations_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0327(08)00398-4 DB - PRIME DP - Unbound Medicine ER -