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The curious case of the tumour virus: 50 years of Burkitt's lymphoma.
Nat Rev Microbiol 2008; 6(12):913-24NR

Abstract

Burkitt's lymphoma (BL) was first described 50 years ago, and the first human tumour virus Epstein-Barr virus (EBV) was discovered in BL tumours soon after. Since then, the role of EBV in the development of BL has become more and more enigmatic. Only recently have we finally begun to understand, at the cellular and molecular levels, the complex and interesting interaction of EBV with B cells that creates a predisposition for the development of BL. Here, we discuss the intertwined histories of EBV and BL and their relationship to the cofactors in BL pathogenesis: malaria and the MYC translocation.

Authors+Show Affiliations

Department of Pathology, Jaharis Building, Tufts University School of Medicine, 150 Harrison Avenue, Boston, Massachusetts 02111, USA. david.thorleylawson@tufts.eduNo affiliation info available

Pub Type(s)

Historical Article
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19008891

Citation

Thorley-Lawson, David A., and Martin J. Allday. "The Curious Case of the Tumour Virus: 50 Years of Burkitt's Lymphoma." Nature Reviews. Microbiology, vol. 6, no. 12, 2008, pp. 913-24.
Thorley-Lawson DA, Allday MJ. The curious case of the tumour virus: 50 years of Burkitt's lymphoma. Nat Rev Microbiol. 2008;6(12):913-24.
Thorley-Lawson, D. A., & Allday, M. J. (2008). The curious case of the tumour virus: 50 years of Burkitt's lymphoma. Nature Reviews. Microbiology, 6(12), pp. 913-24. doi:10.1038/nrmicro2015.
Thorley-Lawson DA, Allday MJ. The Curious Case of the Tumour Virus: 50 Years of Burkitt's Lymphoma. Nat Rev Microbiol. 2008;6(12):913-24. PubMed PMID: 19008891.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The curious case of the tumour virus: 50 years of Burkitt's lymphoma. AU - Thorley-Lawson,David A, AU - Allday,Martin J, PY - 2008/11/15/pubmed PY - 2008/12/17/medline PY - 2008/11/15/entrez SP - 913 EP - 24 JF - Nature reviews. Microbiology JO - Nat. Rev. Microbiol. VL - 6 IS - 12 N2 - Burkitt's lymphoma (BL) was first described 50 years ago, and the first human tumour virus Epstein-Barr virus (EBV) was discovered in BL tumours soon after. Since then, the role of EBV in the development of BL has become more and more enigmatic. Only recently have we finally begun to understand, at the cellular and molecular levels, the complex and interesting interaction of EBV with B cells that creates a predisposition for the development of BL. Here, we discuss the intertwined histories of EBV and BL and their relationship to the cofactors in BL pathogenesis: malaria and the MYC translocation. SN - 1740-1534 UR - https://www.unboundmedicine.com/medline/citation/19008891/The_curious_case_of_the_tumour_virus:_50_years_of_Burkitt's_lymphoma_ L2 - http://dx.doi.org/10.1038/nrmicro2015 DB - PRIME DP - Unbound Medicine ER -