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[Effect of the antibiotic D-cycloserine and its dimer on the activity of tyrosine aminotransferase in liver tissue of intact, adrenalectomized and hypophysectomized rats].
Vopr Med Khim. 1975 May-Jun; 21(3):272-6.VM

Abstract

In a period of lowest day activity of tyrosine aminotransferase, within 6-8 days after bilatheral adrenalectomy, the enzyme activity was decreased by about 20% as compared with an adequate control. At the same time, within a day and seven days after hypophisectomy, in rat liver tissue the enzyme activity was increased, approximately two-fold as compared with the normal state. Within four hrs after intraperitoneal administration into intact fasting rats at a dose of 2-2.5 g per 1 kg of body weight D-cycloserine and its dimer caused an induction of tyrosine aminotransferase by 75% and 180%, respectively. Induction of the enzyme by D-cycloserine and its dimer was inhibited by actinomycin D; the phenomenon was not observed in adrenalectomized rats. Within a day after hypophisectomy D-cycloserine did not cause the induction of tyrosine aminotransferase in rat liver tissue; to the contrary, the dimer of D-cycloserine caused induction of the enzyme, comparable to the ACTH effect, in liver tissue of hypophisectomized rats.

Authors

Marveeva AA
No affiliation info available
Valueva IM
No affiliation info available
Bukin YV
No affiliation info available

MeSH

AdrenalectomyAdrenocorticotropic HormoneAnimalsCycloserineEnzyme InductionHypophysectomyLiverRatsTyrosine Transaminase

Pub Type(s)

English Abstract
Journal Article

Language

rus

PubMed ID

1901

Citation

Marveeva, A A., et al. "[Effect of the Antibiotic D-cycloserine and Its Dimer On the Activity of Tyrosine Aminotransferase in Liver Tissue of Intact, Adrenalectomized and Hypophysectomized Rats]." Voprosy Meditsinskoi Khimii, vol. 21, no. 3, 1975, pp. 272-6.
Marveeva AA, Valueva IM, Bukin YV. [Effect of the antibiotic D-cycloserine and its dimer on the activity of tyrosine aminotransferase in liver tissue of intact, adrenalectomized and hypophysectomized rats]. Vopr Med Khim. 1975;21(3):272-6.
Marveeva, A. A., Valueva, I. M., & Bukin, Y. V. (1975). [Effect of the antibiotic D-cycloserine and its dimer on the activity of tyrosine aminotransferase in liver tissue of intact, adrenalectomized and hypophysectomized rats]. Voprosy Meditsinskoi Khimii, 21(3), 272-6.
Marveeva AA, Valueva IM, Bukin YV. [Effect of the Antibiotic D-cycloserine and Its Dimer On the Activity of Tyrosine Aminotransferase in Liver Tissue of Intact, Adrenalectomized and Hypophysectomized Rats]. Vopr Med Khim. 1975 May-Jun;21(3):272-6. PubMed PMID: 1901.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of the antibiotic D-cycloserine and its dimer on the activity of tyrosine aminotransferase in liver tissue of intact, adrenalectomized and hypophysectomized rats]. AU - Marveeva,A A, AU - Valueva,I M, AU - Bukin,Y V, PY - 1975/5/1/pubmed PY - 1975/5/1/medline PY - 1975/5/1/entrez SP - 272 EP - 6 JF - Voprosy meditsinskoi khimii JO - Vopr Med Khim VL - 21 IS - 3 N2 - In a period of lowest day activity of tyrosine aminotransferase, within 6-8 days after bilatheral adrenalectomy, the enzyme activity was decreased by about 20% as compared with an adequate control. At the same time, within a day and seven days after hypophisectomy, in rat liver tissue the enzyme activity was increased, approximately two-fold as compared with the normal state. Within four hrs after intraperitoneal administration into intact fasting rats at a dose of 2-2.5 g per 1 kg of body weight D-cycloserine and its dimer caused an induction of tyrosine aminotransferase by 75% and 180%, respectively. Induction of the enzyme by D-cycloserine and its dimer was inhibited by actinomycin D; the phenomenon was not observed in adrenalectomized rats. Within a day after hypophisectomy D-cycloserine did not cause the induction of tyrosine aminotransferase in rat liver tissue; to the contrary, the dimer of D-cycloserine caused induction of the enzyme, comparable to the ACTH effect, in liver tissue of hypophisectomized rats. SN - 0042-8809 UR - https://www.unboundmedicine.com/medline/citation/1901/[Effect_of_the_antibiotic_D_cycloserine_and_its_dimer_on_the_activity_of_tyrosine_aminotransferase_in_liver_tissue_of_intact_adrenalectomized_and_hypophysectomized_rats]_ DB - PRIME DP - Unbound Medicine ER -