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Follow-up of mild papilledema in idiopathic intracranial hypertension with optical coherence tomography.
Invest Ophthalmol Vis Sci. 2009 Nov; 50(11):5197-200.IO

Abstract

PURPOSE

To evaluate optical coherence tomography (OCT) measurement of peripapillary retinal nerve fiber layer (RNFL) thickness in patients with mild papilledema associated with idiopathic intracranial hypertension.

METHODS

Patients with papilledema underwent a complete ophthalmic examination, including peripapillary RNFL analysis with OCT (Fast RNFL thickness 3.46; Carl Zeiss Meditec, Inc., Dublin, CA) at diagnosis and 3, 6, and 12 months after presentation. Age- and sex-matched control subjects underwent a similar evaluation. Changes in RNFL overall thickness and by quadrant and interocular differences were evaluated and studied regarding changes in visual field global indices (mean deviation [MD] and pattern SD [PSD]).

RESULTS

Both eyes of 22 patients with mild papilledema and 22 control subjects were included. At diagnosis, the RNFL thickness was 183.3 +/- 74.7 microm and 74.9% (78.5 microm) greater than in control eyes. Mean RNFL thicknesses in all quadrants were significantly greater in eyes with papilledema (P = 0.000). The mean average RNFL was significantly correlated with the MD (sigma = -0.451, P = 0.002) and PSD (sigma = 0.370, P = 0.013) at diagnosis. The RNFL thickness decreased significantly (P = 0.000), whereas the mean MD and the mean PSD improved (P = 0.000 and P = 0.005, respectively) at each follow-up visit. Regression analysis showed that for every 10 microm of mean RNFL thickness increase at baseline, there was a 0.6-dB decrease in MD at the last follow-up.

CONCLUSIONS

Peripapillary RNFL thickness abnormalities assessed by OCT in patients with mild papilledema were quantitatively correlated with visual field sensitivity losses. The data support the possible use of OCT as a noninvasive quantitative method of monitoring the amount and evolution of papilledema.

Authors+Show Affiliations

Department of Ophthalmology, Glaucoma Unit, Hospital Ramón y Cajal, Madrid, Spain. grebolleda@telefonica.netNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19011007

Citation

Rebolleda, Gema, and Francisco J. Muñoz-Negrete. "Follow-up of Mild Papilledema in Idiopathic Intracranial Hypertension With Optical Coherence Tomography." Investigative Ophthalmology & Visual Science, vol. 50, no. 11, 2009, pp. 5197-200.
Rebolleda G, Muñoz-Negrete FJ. Follow-up of mild papilledema in idiopathic intracranial hypertension with optical coherence tomography. Invest Ophthalmol Vis Sci. 2009;50(11):5197-200.
Rebolleda, G., & Muñoz-Negrete, F. J. (2009). Follow-up of mild papilledema in idiopathic intracranial hypertension with optical coherence tomography. Investigative Ophthalmology & Visual Science, 50(11), 5197-200. https://doi.org/10.1167/iovs.08-2528
Rebolleda G, Muñoz-Negrete FJ. Follow-up of Mild Papilledema in Idiopathic Intracranial Hypertension With Optical Coherence Tomography. Invest Ophthalmol Vis Sci. 2009;50(11):5197-200. PubMed PMID: 19011007.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Follow-up of mild papilledema in idiopathic intracranial hypertension with optical coherence tomography. AU - Rebolleda,Gema, AU - Muñoz-Negrete,Francisco J, Y1 - 2008/11/14/ PY - 2008/11/18/pubmed PY - 2009/12/16/medline PY - 2008/11/18/entrez SP - 5197 EP - 200 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 50 IS - 11 N2 - PURPOSE: To evaluate optical coherence tomography (OCT) measurement of peripapillary retinal nerve fiber layer (RNFL) thickness in patients with mild papilledema associated with idiopathic intracranial hypertension. METHODS: Patients with papilledema underwent a complete ophthalmic examination, including peripapillary RNFL analysis with OCT (Fast RNFL thickness 3.46; Carl Zeiss Meditec, Inc., Dublin, CA) at diagnosis and 3, 6, and 12 months after presentation. Age- and sex-matched control subjects underwent a similar evaluation. Changes in RNFL overall thickness and by quadrant and interocular differences were evaluated and studied regarding changes in visual field global indices (mean deviation [MD] and pattern SD [PSD]). RESULTS: Both eyes of 22 patients with mild papilledema and 22 control subjects were included. At diagnosis, the RNFL thickness was 183.3 +/- 74.7 microm and 74.9% (78.5 microm) greater than in control eyes. Mean RNFL thicknesses in all quadrants were significantly greater in eyes with papilledema (P = 0.000). The mean average RNFL was significantly correlated with the MD (sigma = -0.451, P = 0.002) and PSD (sigma = 0.370, P = 0.013) at diagnosis. The RNFL thickness decreased significantly (P = 0.000), whereas the mean MD and the mean PSD improved (P = 0.000 and P = 0.005, respectively) at each follow-up visit. Regression analysis showed that for every 10 microm of mean RNFL thickness increase at baseline, there was a 0.6-dB decrease in MD at the last follow-up. CONCLUSIONS: Peripapillary RNFL thickness abnormalities assessed by OCT in patients with mild papilledema were quantitatively correlated with visual field sensitivity losses. The data support the possible use of OCT as a noninvasive quantitative method of monitoring the amount and evolution of papilledema. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/19011007/Follow_up_of_mild_papilledema_in_idiopathic_intracranial_hypertension_with_optical_coherence_tomography_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.08-2528 DB - PRIME DP - Unbound Medicine ER -