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Effects of dietary alpha-linolenic acid, eicosapentaenoic acid or docosahexaenoic acid on parameters of glucose metabolism in healthy volunteers.
Ann Nutr Metab. 2008; 53(3-4):182-7.AN

Abstract

AIM

To investigate the effects of alpha-linolenic acid (ALA) and purified eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) on fasting concentrations of glucose, insulin, fructosamine, on glycosylated haemoglobin (HbA1c) and on insulin sensitivity.

METHODS

A randomized strictly controlled dietary study in 48 healthy volunteers (13 males, 35 females) of normal body weight (mean age 25.9 years) with three dietary groups (ALA, EPA and DHA) and a parallel design, consisting of two consecutive periods. Subjects received a 2-week wash-in diet rich in monounsaturated fatty acids followed by experimental diets enriched with equal amounts of ALA, EPA, or DHA for 3 weeks. Mean dietary intake of ALA in the ALA group was 6.0 g/day (2.5% of energy intake), mean intake of EPA in the EPA group was 2.8 g/day (1.1% of energy intake) and mean intake of DHA in the DHA group was 2.9 g/day (1.1% of energy intake).

RESULTS

Fasting serum concentrations of insulin and fructosamine and of HbA1c did not change significantly after consuming the ALA, EPA or DHA diet. Fasting serum glucose levels did not change significantly following either the ALA or DHA diet. During the EPA diet, fasting glucose concentration slightly increased by 0.15 mmol/l (p<0.05). All measured values of all subjects were in the reference ranges for healthy adults. No effects on insulin sensitivity indicated by the HOMA insulin resistance index could be observed.

CONCLUSIONS

Except for the minor effect of EPA on fasting glucose levels, the moderate amounts of dietary ALA, EPA or DHA administered in this study did not significantly affect blood concentrations of glucose, insulin, fructosamine and HbA1c in healthy normal-weight men and women over a time course of 3 weeks.

Authors+Show Affiliations

Institute of Human Nutrition and Food Science, Kiel University, Kiel, Germany. s-egert@nutrfoodsc.uni-kiel.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19011281

Citation

Egert, Sarah, et al. "Effects of Dietary Alpha-linolenic Acid, Eicosapentaenoic Acid or Docosahexaenoic Acid On Parameters of Glucose Metabolism in Healthy Volunteers." Annals of Nutrition & Metabolism, vol. 53, no. 3-4, 2008, pp. 182-7.
Egert S, Fobker M, Andersen G, et al. Effects of dietary alpha-linolenic acid, eicosapentaenoic acid or docosahexaenoic acid on parameters of glucose metabolism in healthy volunteers. Ann Nutr Metab. 2008;53(3-4):182-7.
Egert, S., Fobker, M., Andersen, G., Somoza, V., Erbersdobler, H. F., & Wahrburg, U. (2008). Effects of dietary alpha-linolenic acid, eicosapentaenoic acid or docosahexaenoic acid on parameters of glucose metabolism in healthy volunteers. Annals of Nutrition & Metabolism, 53(3-4), 182-7. https://doi.org/10.1159/000172980
Egert S, et al. Effects of Dietary Alpha-linolenic Acid, Eicosapentaenoic Acid or Docosahexaenoic Acid On Parameters of Glucose Metabolism in Healthy Volunteers. Ann Nutr Metab. 2008;53(3-4):182-7. PubMed PMID: 19011281.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of dietary alpha-linolenic acid, eicosapentaenoic acid or docosahexaenoic acid on parameters of glucose metabolism in healthy volunteers. AU - Egert,Sarah, AU - Fobker,Manfred, AU - Andersen,Gaby, AU - Somoza,Veronika, AU - Erbersdobler,Helmut F, AU - Wahrburg,Ursel, Y1 - 2008/11/14/ PY - 2008/03/23/received PY - 2008/09/16/accepted PY - 2008/11/18/pubmed PY - 2009/4/18/medline PY - 2008/11/18/entrez SP - 182 EP - 7 JF - Annals of nutrition & metabolism JO - Ann Nutr Metab VL - 53 IS - 3-4 N2 - AIM: To investigate the effects of alpha-linolenic acid (ALA) and purified eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) on fasting concentrations of glucose, insulin, fructosamine, on glycosylated haemoglobin (HbA1c) and on insulin sensitivity. METHODS: A randomized strictly controlled dietary study in 48 healthy volunteers (13 males, 35 females) of normal body weight (mean age 25.9 years) with three dietary groups (ALA, EPA and DHA) and a parallel design, consisting of two consecutive periods. Subjects received a 2-week wash-in diet rich in monounsaturated fatty acids followed by experimental diets enriched with equal amounts of ALA, EPA, or DHA for 3 weeks. Mean dietary intake of ALA in the ALA group was 6.0 g/day (2.5% of energy intake), mean intake of EPA in the EPA group was 2.8 g/day (1.1% of energy intake) and mean intake of DHA in the DHA group was 2.9 g/day (1.1% of energy intake). RESULTS: Fasting serum concentrations of insulin and fructosamine and of HbA1c did not change significantly after consuming the ALA, EPA or DHA diet. Fasting serum glucose levels did not change significantly following either the ALA or DHA diet. During the EPA diet, fasting glucose concentration slightly increased by 0.15 mmol/l (p<0.05). All measured values of all subjects were in the reference ranges for healthy adults. No effects on insulin sensitivity indicated by the HOMA insulin resistance index could be observed. CONCLUSIONS: Except for the minor effect of EPA on fasting glucose levels, the moderate amounts of dietary ALA, EPA or DHA administered in this study did not significantly affect blood concentrations of glucose, insulin, fructosamine and HbA1c in healthy normal-weight men and women over a time course of 3 weeks. SN - 1421-9697 UR - https://www.unboundmedicine.com/medline/citation/19011281/Effects_of_dietary_alpha_linolenic_acid_eicosapentaenoic_acid_or_docosahexaenoic_acid_on_parameters_of_glucose_metabolism_in_healthy_volunteers_ L2 - https://www.karger.com?DOI=10.1159/000172980 DB - PRIME DP - Unbound Medicine ER -