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Pediatric scrub typhus in Indian Himalayas.
Indian J Pediatr 2008; 75(9):947-9IJ

Abstract

To retrospectively confirm the suspected rickettsial disease (Scrub typhus) using a gold standard diagnostic test i.e. microimmunofluorescence in pediatric patients with acute febrile illness of unknown etiology. Two serological tests, Weil-Felix and Microimmunofluorescence were used to confirm infection. All five children had fever, vomiting and generalized lymphadenopathy, but none had eschar or rash. One was cured with doxycycline, remaining four patients treated with azithromycin and one died despite treatment. Scrub typhus is a cause of fever of unknown origin in Himalayan region of India and azithromycin is an effective alternative to doxycycline in treating this disease.

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  • Publisher Full Text

    • Authors+Show Affiliations

    Mahajan SK
    Department of Pediatrics, IG Medical College, Shimla, HP, India. sanjay_mahajan64@rediffmail.com
    Rolain JM
    No affiliation info available
    Sankhyan N
    No affiliation info available
    Kaushal RK
    No affiliation info available
    Raoult D
    No affiliation info available

    MeSH

    Anti-Bacterial AgentsAzithromycinChildChild, PreschoolDoxycyclineFatal OutcomeFemaleFever of Unknown OriginFluorescent Antibody TechniqueHumansIndiaMaleOrientia tsutsugamushiRetrospective StudiesScrub TyphusTreatment Outcome

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng

    PubMed ID

    19011809

    Citation

    Mahajan, Sanjay K., et al. "Pediatric Scrub Typhus in Indian Himalayas." Indian Journal of Pediatrics, vol. 75, no. 9, 2008, pp. 947-9.
    Mahajan SK, Rolain JM, Sankhyan N, et al. Pediatric scrub typhus in Indian Himalayas. Indian J Pediatr. 2008;75(9):947-9.
    Mahajan, S. K., Rolain, J. M., Sankhyan, N., Kaushal, R. K., & Raoult, D. (2008). Pediatric scrub typhus in Indian Himalayas. Indian Journal of Pediatrics, 75(9), pp. 947-9. doi:10.1007/s12098-008-0198-z.
    Mahajan SK, et al. Pediatric Scrub Typhus in Indian Himalayas. Indian J Pediatr. 2008;75(9):947-9. PubMed PMID: 19011809.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Pediatric scrub typhus in Indian Himalayas. AU - Mahajan,Sanjay K, AU - Rolain,Jean-Marc, AU - Sankhyan,Naveen, AU - Kaushal,Ram Krishan, AU - Raoult,Didier, Y1 - 2008/11/15/ PY - 2007/07/20/received PY - 2008/02/18/accepted PY - 2008/11/18/pubmed PY - 2008/12/17/medline PY - 2008/11/18/entrez SP - 947 EP - 9 JF - Indian journal of pediatrics JO - Indian J Pediatr VL - 75 IS - 9 N2 - To retrospectively confirm the suspected rickettsial disease (Scrub typhus) using a gold standard diagnostic test i.e. microimmunofluorescence in pediatric patients with acute febrile illness of unknown etiology. Two serological tests, Weil-Felix and Microimmunofluorescence were used to confirm infection. All five children had fever, vomiting and generalized lymphadenopathy, but none had eschar or rash. One was cured with doxycycline, remaining four patients treated with azithromycin and one died despite treatment. Scrub typhus is a cause of fever of unknown origin in Himalayan region of India and azithromycin is an effective alternative to doxycycline in treating this disease. SN - 0973-7693 UR - https://www.unboundmedicine.com/medline/citation/19011809/Pediatric_scrub_typhus_in_Indian_Himalayas_ L2 - https://dx.doi.org/10.1007/s12098-008-0198-z DB - PRIME DP - Unbound Medicine ER -