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Pediatric scrub typhus in Indian Himalayas.
Indian J Pediatr. 2008 Sep; 75(9):947-9.IJ

Abstract

To retrospectively confirm the suspected rickettsial disease (Scrub typhus) using a gold standard diagnostic test i.e. microimmunofluorescence in pediatric patients with acute febrile illness of unknown etiology. Two serological tests, Weil-Felix and Microimmunofluorescence were used to confirm infection. All five children had fever, vomiting and generalized lymphadenopathy, but none had eschar or rash. One was cured with doxycycline, remaining four patients treated with azithromycin and one died despite treatment. Scrub typhus is a cause of fever of unknown origin in Himalayan region of India and azithromycin is an effective alternative to doxycycline in treating this disease.

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Authors+Show Affiliations

Mahajan SK
Department of Pediatrics, IG Medical College, Shimla, HP, India. sanjay_mahajan64@rediffmail.com
Rolain JM
No affiliation info available
Sankhyan N
No affiliation info available
Kaushal RK
No affiliation info available
Raoult D
No affiliation info available

MeSH

Anti-Bacterial AgentsAzithromycinChildChild, PreschoolDoxycyclineFatal OutcomeFemaleFever of Unknown OriginFluorescent Antibody TechniqueHumansIndiaMaleOrientia tsutsugamushiRetrospective StudiesScrub TyphusTreatment Outcome

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

19011809

Citation

Mahajan, Sanjay K., et al. "Pediatric Scrub Typhus in Indian Himalayas." Indian Journal of Pediatrics, vol. 75, no. 9, 2008, pp. 947-9.
Mahajan SK, Rolain JM, Sankhyan N, et al. Pediatric scrub typhus in Indian Himalayas. Indian J Pediatr. 2008;75(9):947-9.
Mahajan, S. K., Rolain, J. M., Sankhyan, N., Kaushal, R. K., & Raoult, D. (2008). Pediatric scrub typhus in Indian Himalayas. Indian Journal of Pediatrics, 75(9), 947-9. https://doi.org/10.1007/s12098-008-0198-z
Mahajan SK, et al. Pediatric Scrub Typhus in Indian Himalayas. Indian J Pediatr. 2008;75(9):947-9. PubMed PMID: 19011809.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pediatric scrub typhus in Indian Himalayas. AU - Mahajan,Sanjay K, AU - Rolain,Jean-Marc, AU - Sankhyan,Naveen, AU - Kaushal,Ram Krishan, AU - Raoult,Didier, Y1 - 2008/11/15/ PY - 2007/07/20/received PY - 2008/02/18/accepted PY - 2008/11/18/pubmed PY - 2008/12/17/medline PY - 2008/11/18/entrez SP - 947 EP - 9 JF - Indian journal of pediatrics JO - Indian J Pediatr VL - 75 IS - 9 N2 - To retrospectively confirm the suspected rickettsial disease (Scrub typhus) using a gold standard diagnostic test i.e. microimmunofluorescence in pediatric patients with acute febrile illness of unknown etiology. Two serological tests, Weil-Felix and Microimmunofluorescence were used to confirm infection. All five children had fever, vomiting and generalized lymphadenopathy, but none had eschar or rash. One was cured with doxycycline, remaining four patients treated with azithromycin and one died despite treatment. Scrub typhus is a cause of fever of unknown origin in Himalayan region of India and azithromycin is an effective alternative to doxycycline in treating this disease. SN - 0973-7693 UR - https://www.unboundmedicine.com/medline/citation/19011809/Pediatric_scrub_typhus_in_Indian_Himalayas_ L2 - https://dx.doi.org/10.1007/s12098-008-0198-z DB - PRIME DP - Unbound Medicine ER -