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[Depression in Parkinson's disease. Part 1: epidemiology, signs and symptoms, pathophysiology and diagnosis].
Fortschr Neurol Psychiatr. 2008 Dec; 76(12):715-24.FN

Abstract

Non-motor symptoms, such as psychiatric symptoms and autonomic dysfunction, are common co-morbid conditions in Parkinson's disease (PD) and major contributors to poor quality of life and disability. Within the group of neuropsychiatric conditions, depressive symptoms are the most common condition. Despite their frequency and importance, depressive symptoms can be difficult to assess and diagnose and thus depression in PD is frequently unrealized. Diagnostic challenges include the overlap of depressive symptoms with motor and non-motor symptoms of PD, such as dementia and apathy. Furthermore, there are no definite standards to assess and diagnose depression in PD leading also to the lack of exact data on the epidemiology of this non-motor symptom in PD. Depending on the diagnostic test and the study design the prevalence of depression in PD is reported between 7 and 72% of PD patients with approximately 40% in most cross-sectional studies. In contrast, the pathogenesis and long-term course of depression in PD remain elusive. Current hypothesis, however, includes that depressive symptoms are part of the core condition of PD when regarded as an entity. The present review summarizes the current knowledge on epidemiology, pathogenesis and diagnosis of depression in PD and proposes on this data base a standard procedure for screening and diagnosis of depressive symptoms in PD.

Authors+Show Affiliations

Klinik und Poliklinik für Neurologie, Universitätsklinikum Carl Gustav Carus, Dresden. alexander.storch@neuro.med.tu-dresden.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

ger

PubMed ID

19012223

Citation

Storch, A, et al. "[Depression in Parkinson's Disease. Part 1: Epidemiology, Signs and Symptoms, Pathophysiology and Diagnosis]." Fortschritte Der Neurologie-Psychiatrie, vol. 76, no. 12, 2008, pp. 715-24.
Storch A, Ebersbach G, Fuchs G, et al. [Depression in Parkinson's disease. Part 1: epidemiology, signs and symptoms, pathophysiology and diagnosis]. Fortschr Neurol Psychiatr. 2008;76(12):715-24.
Storch, A., Ebersbach, G., Fuchs, G., Jost, W. H., Odin, P., Reifschneider, G., & Bauer, M. (2008). [Depression in Parkinson's disease. Part 1: epidemiology, signs and symptoms, pathophysiology and diagnosis]. Fortschritte Der Neurologie-Psychiatrie, 76(12), 715-24. https://doi.org/10.1055/s-2008-1038293
Storch A, et al. [Depression in Parkinson's Disease. Part 1: Epidemiology, Signs and Symptoms, Pathophysiology and Diagnosis]. Fortschr Neurol Psychiatr. 2008;76(12):715-24. PubMed PMID: 19012223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Depression in Parkinson's disease. Part 1: epidemiology, signs and symptoms, pathophysiology and diagnosis]. AU - Storch,A, AU - Ebersbach,G, AU - Fuchs,G, AU - Jost,W H, AU - Odin,P, AU - Reifschneider,G, AU - Bauer,M, Y1 - 2008/11/14/ PY - 2008/11/18/pubmed PY - 2009/2/10/medline PY - 2008/11/18/entrez SP - 715 EP - 24 JF - Fortschritte der Neurologie-Psychiatrie JO - Fortschr Neurol Psychiatr VL - 76 IS - 12 N2 - Non-motor symptoms, such as psychiatric symptoms and autonomic dysfunction, are common co-morbid conditions in Parkinson's disease (PD) and major contributors to poor quality of life and disability. Within the group of neuropsychiatric conditions, depressive symptoms are the most common condition. Despite their frequency and importance, depressive symptoms can be difficult to assess and diagnose and thus depression in PD is frequently unrealized. Diagnostic challenges include the overlap of depressive symptoms with motor and non-motor symptoms of PD, such as dementia and apathy. Furthermore, there are no definite standards to assess and diagnose depression in PD leading also to the lack of exact data on the epidemiology of this non-motor symptom in PD. Depending on the diagnostic test and the study design the prevalence of depression in PD is reported between 7 and 72% of PD patients with approximately 40% in most cross-sectional studies. In contrast, the pathogenesis and long-term course of depression in PD remain elusive. Current hypothesis, however, includes that depressive symptoms are part of the core condition of PD when regarded as an entity. The present review summarizes the current knowledge on epidemiology, pathogenesis and diagnosis of depression in PD and proposes on this data base a standard procedure for screening and diagnosis of depressive symptoms in PD. SN - 0720-4299 UR - https://www.unboundmedicine.com/medline/citation/19012223/[Depression_in_Parkinson's_disease__Part_1:_epidemiology_signs_and_symptoms_pathophysiology_and_diagnosis]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2008-1038293 DB - PRIME DP - Unbound Medicine ER -