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Folate awareness and the prevalence of neural tube defects in South Australia, 1966-2007.
Med J Aust. 2008 Nov 17; 189(10):566-9.MJ

Abstract

OBJECTIVES

To ascertain changes in: women's knowledge of the role of folic acid in the prevention of neural tube defects (NTDs); intake of folic acid among pregnant women; and prevalence of NTDs in South Australia.

DESIGN, SETTING AND PARTICIPANTS

Computer-assisted telephone interviews of South Australian households from 1994 to 2007 over a period encompassing a statewide folate promotion campaign (1994-1995), continuing folate promotion, as well as the introduction of voluntary folate fortification of foods (1996); ascertainment of the total prevalence of NTDs from births and terminations of pregnancy from 1966 to 2007.

MAIN OUTCOME MEASURES

Changes in women's knowledge of the role of folic acid in the prevention of NTDs; changes in the prevalence of NTDs.

RESULTS

From 1994 to 2006 and 2007, knowledge about the role of folic acid increased from 25% to 77% (P < 0.001) and knowledge that folic acid needs to be taken in the periconceptional period increased from 12% to 39% (P < 0.001). The proportion of pregnant women who increased their periconceptional intake of folate rose from 61% in 1998 to 81% in 2006 and 2007 (P < 0.001), with significant increases in the consumption of fortified cereals (from 15% to 29%) and folic acid tablets (from 37% to 64%). The total prevalence of NTDs fell from 2.06 per 1000 births in 1986-1990 to 1.23 per 1000 births in 2002-2007 (relative risk, 0.60; 95% CI, 0.48-0.74; P < 0.001).

CONCLUSIONS

Folate promotion and voluntary fortification of certain foods with folic acid were associated with increased awareness of the role of periconceptional folic acid, increased folate consumption and a reduction in the prevalence of NTDs in South Australia by 40% (95% CI, 26%-52%).

Authors+Show Affiliations

SA Health, Government of South Australia, Adelaide, SA, Australia. Annabelle.Chan@health.sa.gov.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19012555

Citation

Chan, Annabelle C., et al. "Folate Awareness and the Prevalence of Neural Tube Defects in South Australia, 1966-2007." The Medical Journal of Australia, vol. 189, no. 10, 2008, pp. 566-9.
Chan AC, van Essen P, Scott H, et al. Folate awareness and the prevalence of neural tube defects in South Australia, 1966-2007. Med J Aust. 2008;189(10):566-9.
Chan, A. C., van Essen, P., Scott, H., Haan, E. A., Sage, L., Scott, J., Gill, T. K., & Nguyen, A. M. (2008). Folate awareness and the prevalence of neural tube defects in South Australia, 1966-2007. The Medical Journal of Australia, 189(10), 566-9.
Chan AC, et al. Folate Awareness and the Prevalence of Neural Tube Defects in South Australia, 1966-2007. Med J Aust. 2008 Nov 17;189(10):566-9. PubMed PMID: 19012555.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folate awareness and the prevalence of neural tube defects in South Australia, 1966-2007. AU - Chan,Annabelle C, AU - van Essen,Phillipa, AU - Scott,Heather, AU - Haan,Eric A, AU - Sage,Leonie, AU - Scott,Joan, AU - Gill,Tiffany K, AU - Nguyen,Anh-Minh T, PY - 2008/06/03/received PY - 2008/10/02/accepted PY - 2008/11/18/pubmed PY - 2009/1/14/medline PY - 2008/11/18/entrez SP - 566 EP - 9 JF - The Medical journal of Australia JO - Med. J. Aust. VL - 189 IS - 10 N2 - OBJECTIVES: To ascertain changes in: women's knowledge of the role of folic acid in the prevention of neural tube defects (NTDs); intake of folic acid among pregnant women; and prevalence of NTDs in South Australia. DESIGN, SETTING AND PARTICIPANTS: Computer-assisted telephone interviews of South Australian households from 1994 to 2007 over a period encompassing a statewide folate promotion campaign (1994-1995), continuing folate promotion, as well as the introduction of voluntary folate fortification of foods (1996); ascertainment of the total prevalence of NTDs from births and terminations of pregnancy from 1966 to 2007. MAIN OUTCOME MEASURES: Changes in women's knowledge of the role of folic acid in the prevention of NTDs; changes in the prevalence of NTDs. RESULTS: From 1994 to 2006 and 2007, knowledge about the role of folic acid increased from 25% to 77% (P < 0.001) and knowledge that folic acid needs to be taken in the periconceptional period increased from 12% to 39% (P < 0.001). The proportion of pregnant women who increased their periconceptional intake of folate rose from 61% in 1998 to 81% in 2006 and 2007 (P < 0.001), with significant increases in the consumption of fortified cereals (from 15% to 29%) and folic acid tablets (from 37% to 64%). The total prevalence of NTDs fell from 2.06 per 1000 births in 1986-1990 to 1.23 per 1000 births in 2002-2007 (relative risk, 0.60; 95% CI, 0.48-0.74; P < 0.001). CONCLUSIONS: Folate promotion and voluntary fortification of certain foods with folic acid were associated with increased awareness of the role of periconceptional folic acid, increased folate consumption and a reduction in the prevalence of NTDs in South Australia by 40% (95% CI, 26%-52%). SN - 0025-729X UR - https://www.unboundmedicine.com/medline/citation/19012555/Folate_awareness_and_the_prevalence_of_neural_tube_defects_in_South_Australia_1966_2007_ L2 - https://www.mja.com.au/public/issues/189_10_171108/cha10685_fm.html DB - PRIME DP - Unbound Medicine ER -