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The effect of strawberries in a cholesterol-lowering dietary portfolio.
Metabolism 2008; 57(12):1636-44M

Abstract

Effective diets reduce blood lipids and oxidative damage, both of which have been linked to the complications of diabetes and coronary heart disease. Our objective was to assess the effect of adding strawberries, as a source of antioxidants, to improve the antioxidant effect of a cholesterol-lowering diet (dietary portfolio). To this end, 28 hyperlipidemic subjects who had followed the dietary portfolio consisting of soy, viscous fiber, plant sterol, and nuts for a mean of 2.5 years were randomized to receive supplements of strawberries (454 g/d, 112 kcal) or additional oat bran bread (65 g/d, 112 kcal, approximately 2 g beta-glucan) (control) in a randomized 1-month crossover study with a 2-week washout. Strawberry supplementation resulted in a greater reduction in oxidative damage to low-density lipoprotein (LDL) measured as thiobarbituric acid-reactive substances in the LDL fraction (P = .014). At the end of the strawberry period, reductions in LDL cholesterol and in the ratio of total to high-density lipoprotein cholesterol were maintained close to 1-year values at -13.4% +/- 2.1% and -15.2% +/- 1.7%, respectively (P < .001), and were similar to the post-oat bran bread values. Strawberries also improved the palatability of the diet. We conclude that strawberry supplementation reduced oxidative damage to LDL while maintaining reductions in blood lipids and enhancing diet palatability. Added fruit may improve the overall utility of diets designed to lower coronary heart disease risk.

Authors+Show Affiliations

Clinical Nutrition & Risk Factor Modification Center, St Michael's Hospital, Toronto, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19013285

Citation

Jenkins, David J A., et al. "The Effect of Strawberries in a Cholesterol-lowering Dietary Portfolio." Metabolism: Clinical and Experimental, vol. 57, no. 12, 2008, pp. 1636-44.
Jenkins DJ, Nguyen TH, Kendall CW, et al. The effect of strawberries in a cholesterol-lowering dietary portfolio. Metab Clin Exp. 2008;57(12):1636-44.
Jenkins, D. J., Nguyen, T. H., Kendall, C. W., Faulkner, D. A., Bashyam, B., Kim, I. J., ... Singer, W. (2008). The effect of strawberries in a cholesterol-lowering dietary portfolio. Metabolism: Clinical and Experimental, 57(12), pp. 1636-44. doi:10.1016/j.metabol.2008.07.018.
Jenkins DJ, et al. The Effect of Strawberries in a Cholesterol-lowering Dietary Portfolio. Metab Clin Exp. 2008;57(12):1636-44. PubMed PMID: 19013285.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of strawberries in a cholesterol-lowering dietary portfolio. AU - Jenkins,David J A, AU - Nguyen,Tri H, AU - Kendall,Cyril W C, AU - Faulkner,Dorothea A, AU - Bashyam,Balachandran, AU - Kim,In Joo, AU - Ireland,Chris, AU - Patel,Darshna, AU - Vidgen,Edward, AU - Josse,Andrea R, AU - Sesso,Howard D, AU - Burton-Freeman,Britt, AU - Josse,Robert G, AU - Leiter,Lawrence A, AU - Singer,William, PY - 2008/02/27/received PY - 2008/07/24/accepted PY - 2008/11/18/pubmed PY - 2008/12/17/medline PY - 2008/11/18/entrez SP - 1636 EP - 44 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 57 IS - 12 N2 - Effective diets reduce blood lipids and oxidative damage, both of which have been linked to the complications of diabetes and coronary heart disease. Our objective was to assess the effect of adding strawberries, as a source of antioxidants, to improve the antioxidant effect of a cholesterol-lowering diet (dietary portfolio). To this end, 28 hyperlipidemic subjects who had followed the dietary portfolio consisting of soy, viscous fiber, plant sterol, and nuts for a mean of 2.5 years were randomized to receive supplements of strawberries (454 g/d, 112 kcal) or additional oat bran bread (65 g/d, 112 kcal, approximately 2 g beta-glucan) (control) in a randomized 1-month crossover study with a 2-week washout. Strawberry supplementation resulted in a greater reduction in oxidative damage to low-density lipoprotein (LDL) measured as thiobarbituric acid-reactive substances in the LDL fraction (P = .014). At the end of the strawberry period, reductions in LDL cholesterol and in the ratio of total to high-density lipoprotein cholesterol were maintained close to 1-year values at -13.4% +/- 2.1% and -15.2% +/- 1.7%, respectively (P < .001), and were similar to the post-oat bran bread values. Strawberries also improved the palatability of the diet. We conclude that strawberry supplementation reduced oxidative damage to LDL while maintaining reductions in blood lipids and enhancing diet palatability. Added fruit may improve the overall utility of diets designed to lower coronary heart disease risk. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/19013285/The_effect_of_strawberries_in_a_cholesterol_lowering_dietary_portfolio_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(08)00269-2 DB - PRIME DP - Unbound Medicine ER -