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Helicobacter pylori infection and arterial stiffness in patients with type 2 diabetes mellitus.
Metabolism. 2008 Dec; 57(12):1760-4.M

Abstract

Epidemiologic studies have suggested possible atherogenic roles for such pathogens as Chlamydia pneumoniae, Helicobacter pylori (Hp), cytomegalovirus, and herpes simplex virus. The aim of the present study was to examine the relationship between seropositivity of antibodies to Hp (Hp infection) and arterial stiffness determined by pulse wave velocity (PWV) in 130 patients (73 men and 57 women) with type 2 diabetes mellitus without a history of cardiovascular disease. The prevalence of Hp infection in patients with type 2 diabetes mellitus was 53.8%. Age (66.7 +/- 11.3 vs 60.0 +/- 12.2 years, P = .0014) and systolic blood pressure (138 +/- 19 vs 131 +/- 22 mm Hg, P = .0420) were significantly higher in patients with Hp infection than in those without. Serum C-reactive protein was higher in patients with Hp infection than in those without, although it did not reach statistical significance (0.23 +/- 0.27 vs 0.18 +/- 0.20 mg/dL, P = .2205). Pulse wave velocity was significantly higher in patients with Hp infection than in those without (1877 +/- 550 vs 1585 +/- 331 cm/s, P = .0005). Multiple regression analysis demonstrated that age (beta = .388, P < .0001), mean arterial pressure (beta = .289, P = .0006), hypertensive treatment (beta = .185, P = .0282), and presence of Hp infection (beta = .169, P = .0220) were independent determinants of PWV. In conclusion, Hp infection is associated with arterial stiffness determined by PWV in patients with type 2 diabetes mellitus.

Authors+Show Affiliations

Department of Diabetes and Endocrinology, Matsushita Memorial Hospital, Osaka 570-0096, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19013302

Citation

Ohnishi, Masayoshi, et al. "Helicobacter Pylori Infection and Arterial Stiffness in Patients With Type 2 Diabetes Mellitus." Metabolism: Clinical and Experimental, vol. 57, no. 12, 2008, pp. 1760-4.
Ohnishi M, Fukui M, Ishikawa T, et al. Helicobacter pylori infection and arterial stiffness in patients with type 2 diabetes mellitus. Metabolism. 2008;57(12):1760-4.
Ohnishi, M., Fukui, M., Ishikawa, T., Ohnishi, N., Ishigami, N., Yoshioka, K., Hasegawa, G., Yoshikawa, T., & Nakamura, N. (2008). Helicobacter pylori infection and arterial stiffness in patients with type 2 diabetes mellitus. Metabolism: Clinical and Experimental, 57(12), 1760-4. https://doi.org/10.1016/j.metabol.2008.08.001
Ohnishi M, et al. Helicobacter Pylori Infection and Arterial Stiffness in Patients With Type 2 Diabetes Mellitus. Metabolism. 2008;57(12):1760-4. PubMed PMID: 19013302.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori infection and arterial stiffness in patients with type 2 diabetes mellitus. AU - Ohnishi,Masayoshi, AU - Fukui,Michiaki, AU - Ishikawa,Takeshi, AU - Ohnishi,Nahoko, AU - Ishigami,Noriko, AU - Yoshioka,Keiji, AU - Hasegawa,Goji, AU - Yoshikawa,Toshikazu, AU - Nakamura,Naoto, PY - 2007/06/06/received PY - 2008/08/15/accepted PY - 2008/11/18/pubmed PY - 2008/12/17/medline PY - 2008/11/18/entrez SP - 1760 EP - 4 JF - Metabolism: clinical and experimental JO - Metabolism VL - 57 IS - 12 N2 - Epidemiologic studies have suggested possible atherogenic roles for such pathogens as Chlamydia pneumoniae, Helicobacter pylori (Hp), cytomegalovirus, and herpes simplex virus. The aim of the present study was to examine the relationship between seropositivity of antibodies to Hp (Hp infection) and arterial stiffness determined by pulse wave velocity (PWV) in 130 patients (73 men and 57 women) with type 2 diabetes mellitus without a history of cardiovascular disease. The prevalence of Hp infection in patients with type 2 diabetes mellitus was 53.8%. Age (66.7 +/- 11.3 vs 60.0 +/- 12.2 years, P = .0014) and systolic blood pressure (138 +/- 19 vs 131 +/- 22 mm Hg, P = .0420) were significantly higher in patients with Hp infection than in those without. Serum C-reactive protein was higher in patients with Hp infection than in those without, although it did not reach statistical significance (0.23 +/- 0.27 vs 0.18 +/- 0.20 mg/dL, P = .2205). Pulse wave velocity was significantly higher in patients with Hp infection than in those without (1877 +/- 550 vs 1585 +/- 331 cm/s, P = .0005). Multiple regression analysis demonstrated that age (beta = .388, P < .0001), mean arterial pressure (beta = .289, P = .0006), hypertensive treatment (beta = .185, P = .0282), and presence of Hp infection (beta = .169, P = .0220) were independent determinants of PWV. In conclusion, Hp infection is associated with arterial stiffness determined by PWV in patients with type 2 diabetes mellitus. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/19013302/Helicobacter_pylori_infection_and_arterial_stiffness_in_patients_with_type_2_diabetes_mellitus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(08)00315-6 DB - PRIME DP - Unbound Medicine ER -