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Synthesis and biological evaluation of a series of tangeretin-derived chalcones.
Bioorg Med Chem Lett. 2009 Jan 01; 19(1):167-9.BM

Abstract

A series of chalcones polyoxygenated on the ring A (with pentamethoxy or 2'-hydroxy-3',4',5',6'-tetramethoxy substitution patterns) was synthesized from tangeretin, a natural Citrus flavonoid. These chalcones were evaluated for their antiproliferative, activation of apoptosis, inhibition of tubulin assembly and antileishmanial activities. Comparison with the reference analogous 3',4',5'-trimethoxylated chalcones showed that such peroxygenated substitution patterns on the ring A were less beneficial to these activities.

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Authors+Show Affiliations

Quintin J
Faculté de Pharmacie, Laboratoire de Pharmacognosie, Univ Paris-Sud 11, BIOCIS, UMR-8076 CNRS, Châtenay-Malabry Cedex, France.
Desrivot J
No affiliation info available
Thoret S
No affiliation info available
Le Menez P
No affiliation info available
Cresteil T
No affiliation info available
Lewin G
No affiliation info available

MeSH

AnimalsAntineoplastic AgentsAntiprotozoal AgentsApoptosisCell Line, TumorCell ProliferationChalconesDrug Evaluation, PreclinicalFlavonesHumansLeishmaniaPlant ExtractsStructure-Activity RelationshipTubulin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19013795

Citation

Quintin, Jérôme, et al. "Synthesis and Biological Evaluation of a Series of Tangeretin-derived Chalcones." Bioorganic & Medicinal Chemistry Letters, vol. 19, no. 1, 2009, pp. 167-9.
Quintin J, Desrivot J, Thoret S, et al. Synthesis and biological evaluation of a series of tangeretin-derived chalcones. Bioorg Med Chem Lett. 2009;19(1):167-9.
Quintin, J., Desrivot, J., Thoret, S., Le Menez, P., Cresteil, T., & Lewin, G. (2009). Synthesis and biological evaluation of a series of tangeretin-derived chalcones. Bioorganic & Medicinal Chemistry Letters, 19(1), 167-9. https://doi.org/10.1016/j.bmcl.2008.10.126
Quintin J, et al. Synthesis and Biological Evaluation of a Series of Tangeretin-derived Chalcones. Bioorg Med Chem Lett. 2009 Jan 1;19(1):167-9. PubMed PMID: 19013795.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis and biological evaluation of a series of tangeretin-derived chalcones. AU - Quintin,Jérôme, AU - Desrivot,Julie, AU - Thoret,Sylviane, AU - Le Menez,Patrick, AU - Cresteil,Thierry, AU - Lewin,Guy, Y1 - 2008/11/05/ PY - 2008/09/23/received PY - 2008/10/27/revised PY - 2008/10/28/accepted PY - 2008/11/18/pubmed PY - 2009/1/29/medline PY - 2008/11/18/entrez SP - 167 EP - 9 JF - Bioorganic & medicinal chemistry letters JO - Bioorg Med Chem Lett VL - 19 IS - 1 N2 - A series of chalcones polyoxygenated on the ring A (with pentamethoxy or 2'-hydroxy-3',4',5',6'-tetramethoxy substitution patterns) was synthesized from tangeretin, a natural Citrus flavonoid. These chalcones were evaluated for their antiproliferative, activation of apoptosis, inhibition of tubulin assembly and antileishmanial activities. Comparison with the reference analogous 3',4',5'-trimethoxylated chalcones showed that such peroxygenated substitution patterns on the ring A were less beneficial to these activities. SN - 1464-3405 UR - https://www.unboundmedicine.com/medline/citation/19013795/Synthesis_and_biological_evaluation_of_a_series_of_tangeretin_derived_chalcones_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-894X(08)01342-5 DB - PRIME DP - Unbound Medicine ER -