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The effect of growth hormone treatment on head circumference in growth hormone-deficient children.
Turk J Pediatr. 2008 Jul-Aug; 50(4):331-5.TJ

Abstract

The aim of this study was to analyze head circumference (HC) growth retrospectively in longitudinally followed growth hormone (GH)-deficient children on GH therapy. Data of 54 (25 F, 29 M) children with GH deficiency were analyzed by dividing the children into two groups: Group 1 with height age (HA) < or =5 years (yrs) (n:18) and Group 2 with HA >5 yrs (n:36). Anthropometric measurements were expressed as standard deviation score (SDS) for chronological age (CA), and HC was also expressed as SDS for CA and HA. Group 1, with CA 6.6 (2.9) yrs at onset of therapy, showed an increase in height SDS from -3.8 (1.4) to -2.4 (1.7) (p < 0.001) and in HC SDS for CA from -1.9 (1.5) to -1.3 (1.6) (p < 0.05) on 4.8 (3.5) yrs of therapy. Group 2, with CA 12.6(2.2) yrs, increased height SDS from -3.4 (1.3) to -2.5 (1.4) (p < 0.001) and HC SDS for CA from -1.2 (1.3) to -1.4(1.2) (NS). HC SDS for HA was -0.4(1.3) in Group 1 and -0.2 (1.1) in Group 2 and showed no significant change. When analyzed by quartiles for cumulative dose of GH, HC SDS for HA became 0.08(1.2) in the fourth dosage quartile (p = 0.043), not significantly different from the mean. HC is disproportionately small for age but normal for the height. GH treatment results in an increase in HC of the children towards normalization in younger children. An increase in cumulative GH dose is associated with an increase in HC, but this is not inappropriate.

Authors+Show Affiliations

Unit of Pediatric Endocrinology, Department of Pediatrics, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19014045

Citation

Darendeliler, Feyza, et al. "The Effect of Growth Hormone Treatment On Head Circumference in Growth Hormone-deficient Children." The Turkish Journal of Pediatrics, vol. 50, no. 4, 2008, pp. 331-5.
Darendeliler F, Baş F, Gökçe M, et al. The effect of growth hormone treatment on head circumference in growth hormone-deficient children. Turk J Pediatr. 2008;50(4):331-5.
Darendeliler, F., Baş, F., Gökçe, M., Poyrazoğlu, S., Sükür, M., Bundak, R., Saka, N., & Günöz, H. (2008). The effect of growth hormone treatment on head circumference in growth hormone-deficient children. The Turkish Journal of Pediatrics, 50(4), 331-5.
Darendeliler F, et al. The Effect of Growth Hormone Treatment On Head Circumference in Growth Hormone-deficient Children. Turk J Pediatr. 2008 Jul-Aug;50(4):331-5. PubMed PMID: 19014045.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of growth hormone treatment on head circumference in growth hormone-deficient children. AU - Darendeliler,Feyza, AU - Baş,Firdevs, AU - Gökçe,Müge, AU - Poyrazoğlu,Sükran, AU - Sükür,Mine, AU - Bundak,Rüveyde, AU - Saka,Nurçin, AU - Günöz,Hülya, PY - 2008/11/19/pubmed PY - 2008/12/17/medline PY - 2008/11/19/entrez SP - 331 EP - 5 JF - The Turkish journal of pediatrics JO - Turk J Pediatr VL - 50 IS - 4 N2 - The aim of this study was to analyze head circumference (HC) growth retrospectively in longitudinally followed growth hormone (GH)-deficient children on GH therapy. Data of 54 (25 F, 29 M) children with GH deficiency were analyzed by dividing the children into two groups: Group 1 with height age (HA) < or =5 years (yrs) (n:18) and Group 2 with HA >5 yrs (n:36). Anthropometric measurements were expressed as standard deviation score (SDS) for chronological age (CA), and HC was also expressed as SDS for CA and HA. Group 1, with CA 6.6 (2.9) yrs at onset of therapy, showed an increase in height SDS from -3.8 (1.4) to -2.4 (1.7) (p < 0.001) and in HC SDS for CA from -1.9 (1.5) to -1.3 (1.6) (p < 0.05) on 4.8 (3.5) yrs of therapy. Group 2, with CA 12.6(2.2) yrs, increased height SDS from -3.4 (1.3) to -2.5 (1.4) (p < 0.001) and HC SDS for CA from -1.2 (1.3) to -1.4(1.2) (NS). HC SDS for HA was -0.4(1.3) in Group 1 and -0.2 (1.1) in Group 2 and showed no significant change. When analyzed by quartiles for cumulative dose of GH, HC SDS for HA became 0.08(1.2) in the fourth dosage quartile (p = 0.043), not significantly different from the mean. HC is disproportionately small for age but normal for the height. GH treatment results in an increase in HC of the children towards normalization in younger children. An increase in cumulative GH dose is associated with an increase in HC, but this is not inappropriate. SN - 0041-4301 UR - https://www.unboundmedicine.com/medline/citation/19014045/The_effect_of_growth_hormone_treatment_on_head_circumference_in_growth_hormone_deficient_children_ L2 - https://antibodies.cancer.gov/detail/CPTC-KRAS4B-1 DB - PRIME DP - Unbound Medicine ER -