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Long-term dietary acrylamide intake and breast cancer risk in a prospective cohort of Swedish women.
Am J Epidemiol. 2009 Feb 01; 169(3):376-81.AJ

Abstract

The association between dietary acrylamide intake and the incidence of invasive breast cancer was examined among 61,433 Swedish women who were cancer free and completed a food frequency questionnaire in 1987-1990 and again in 1997. During a mean follow-up of 17.4 years, a total of 2,952 incident cases of breast cancer were diagnosed in the cohort. In multivariate analyses controlling for breast cancer risk factors, no statistically significant association was observed between long-term acrylamide intake (assessed at baseline and in 1997) and the risk of breast cancer, overall or by estrogen receptor (ER) and progesterone receptor (PR) status. The multivariate rate ratios comparing extreme quartiles of acrylamide intake were 0.91 (95% confidence interval (CI): 0.80, 1.02) for overall breast cancer, 0.89 (95% CI: 0.74, 1.08) for ER+PR+ tumors, 1.17 (95% CI: 0.84, 1.64) for ER+PR- tumors, and 0.91 (95% CI: 0.61, 1.38) for ER-PR- tumors. The association between acrylamide intake and breast cancer risk did not differ by smoking status. These findings for Swedish women do not support the hypothesis that dietary acrylamide is positively associated with risk of breast cancer, at least not within the ranges of acrylamide consumed by this population.

Authors+Show Affiliations

Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. susanna.larsson@ki.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19015201

Citation

Larsson, Susanna C., et al. "Long-term Dietary Acrylamide Intake and Breast Cancer Risk in a Prospective Cohort of Swedish Women." American Journal of Epidemiology, vol. 169, no. 3, 2009, pp. 376-81.
Larsson SC, Akesson A, Wolk A. Long-term dietary acrylamide intake and breast cancer risk in a prospective cohort of Swedish women. Am J Epidemiol. 2009;169(3):376-81.
Larsson, S. C., Akesson, A., & Wolk, A. (2009). Long-term dietary acrylamide intake and breast cancer risk in a prospective cohort of Swedish women. American Journal of Epidemiology, 169(3), 376-81. https://doi.org/10.1093/aje/kwn319
Larsson SC, Akesson A, Wolk A. Long-term Dietary Acrylamide Intake and Breast Cancer Risk in a Prospective Cohort of Swedish Women. Am J Epidemiol. 2009 Feb 1;169(3):376-81. PubMed PMID: 19015201.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term dietary acrylamide intake and breast cancer risk in a prospective cohort of Swedish women. AU - Larsson,Susanna C, AU - Akesson,Agneta, AU - Wolk,Alicja, Y1 - 2008/11/17/ PY - 2008/11/19/pubmed PY - 2009/2/10/medline PY - 2008/11/19/entrez SP - 376 EP - 81 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 169 IS - 3 N2 - The association between dietary acrylamide intake and the incidence of invasive breast cancer was examined among 61,433 Swedish women who were cancer free and completed a food frequency questionnaire in 1987-1990 and again in 1997. During a mean follow-up of 17.4 years, a total of 2,952 incident cases of breast cancer were diagnosed in the cohort. In multivariate analyses controlling for breast cancer risk factors, no statistically significant association was observed between long-term acrylamide intake (assessed at baseline and in 1997) and the risk of breast cancer, overall or by estrogen receptor (ER) and progesterone receptor (PR) status. The multivariate rate ratios comparing extreme quartiles of acrylamide intake were 0.91 (95% confidence interval (CI): 0.80, 1.02) for overall breast cancer, 0.89 (95% CI: 0.74, 1.08) for ER+PR+ tumors, 1.17 (95% CI: 0.84, 1.64) for ER+PR- tumors, and 0.91 (95% CI: 0.61, 1.38) for ER-PR- tumors. The association between acrylamide intake and breast cancer risk did not differ by smoking status. These findings for Swedish women do not support the hypothesis that dietary acrylamide is positively associated with risk of breast cancer, at least not within the ranges of acrylamide consumed by this population. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/19015201/Long_term_dietary_acrylamide_intake_and_breast_cancer_risk_in_a_prospective_cohort_of_Swedish_women_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwn319 DB - PRIME DP - Unbound Medicine ER -