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In vitro susceptibility of field isolates of Leishmania donovani to Miltefosine and amphotericin B: correlation with sodium antimony gluconate susceptibility and implications for treatment in areas of endemicity.
Antimicrob Agents Chemother. 2009 Feb; 53(2):835-8.AA

Abstract

Indian Leishmania donovani isolates (n = 19) from regional zones representing various levels of antimony resistance displayed significantly (P < 0.01) correlated results with respect to in vitro susceptibility to the antileishmanial drugs sodium antimony gluconate, amphotericin B, and Miltefosine, raising the possibility of cross-resistance mechanisms operating in the field isolates. The results of gene expression analysis of LdMT and LdRos3 were suggestive of alternate mechanisms of Miltefosine susceptibility in the isolates.

Authors+Show Affiliations

Institute of Pathology, Safdarjung Hospital Campus, New Delhi, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19015344

Citation

Kumar, Dhiraj, et al. "In Vitro Susceptibility of Field Isolates of Leishmania Donovani to Miltefosine and Amphotericin B: Correlation With Sodium Antimony Gluconate Susceptibility and Implications for Treatment in Areas of Endemicity." Antimicrobial Agents and Chemotherapy, vol. 53, no. 2, 2009, pp. 835-8.
Kumar D, Kulshrestha A, Singh R, et al. In vitro susceptibility of field isolates of Leishmania donovani to Miltefosine and amphotericin B: correlation with sodium antimony gluconate susceptibility and implications for treatment in areas of endemicity. Antimicrob Agents Chemother. 2009;53(2):835-8.
Kumar, D., Kulshrestha, A., Singh, R., & Salotra, P. (2009). In vitro susceptibility of field isolates of Leishmania donovani to Miltefosine and amphotericin B: correlation with sodium antimony gluconate susceptibility and implications for treatment in areas of endemicity. Antimicrobial Agents and Chemotherapy, 53(2), 835-8. https://doi.org/10.1128/AAC.01233-08
Kumar D, et al. In Vitro Susceptibility of Field Isolates of Leishmania Donovani to Miltefosine and Amphotericin B: Correlation With Sodium Antimony Gluconate Susceptibility and Implications for Treatment in Areas of Endemicity. Antimicrob Agents Chemother. 2009;53(2):835-8. PubMed PMID: 19015344.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro susceptibility of field isolates of Leishmania donovani to Miltefosine and amphotericin B: correlation with sodium antimony gluconate susceptibility and implications for treatment in areas of endemicity. AU - Kumar,Dhiraj, AU - Kulshrestha,Arpita, AU - Singh,Ruchi, AU - Salotra,Poonam, Y1 - 2008/11/17/ PY - 2008/11/19/pubmed PY - 2009/4/21/medline PY - 2008/11/19/entrez SP - 835 EP - 8 JF - Antimicrobial agents and chemotherapy JO - Antimicrob Agents Chemother VL - 53 IS - 2 N2 - Indian Leishmania donovani isolates (n = 19) from regional zones representing various levels of antimony resistance displayed significantly (P < 0.01) correlated results with respect to in vitro susceptibility to the antileishmanial drugs sodium antimony gluconate, amphotericin B, and Miltefosine, raising the possibility of cross-resistance mechanisms operating in the field isolates. The results of gene expression analysis of LdMT and LdRos3 were suggestive of alternate mechanisms of Miltefosine susceptibility in the isolates. SN - 1098-6596 UR - https://www.unboundmedicine.com/medline/citation/19015344/In_vitro_susceptibility_of_field_isolates_of_Leishmania_donovani_to_Miltefosine_and_amphotericin_B:_correlation_with_sodium_antimony_gluconate_susceptibility_and_implications_for_treatment_in_areas_of_endemicity_ L2 - https://journals.asm.org/doi/10.1128/AAC.01233-08?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -