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Secretory and metabolic effects of ethanol in the isolated amphibian gastric mucosa.
Gastroenterology. 1991 May; 100(5 Pt 1):1288-95.G

Abstract

The effects of pure ethanol and some alcoholic beverages on acid secretion and metabolism were examined in the isolated toad gastric mucosa. Pure ethanol applied to the luminal side or to the submucosal side at low concentrations (2%-10%) was a potent stimulant of acid secretion, whereas high concentrations (greater than or equal to 20%) were inhibitory. Cimetidine and calcium-free solutions did not abolish the secretory effect of ethanol. Beer and wine, but not rum and whisky, caused a significant stimulation of acid secretion. Respiration was progressively increased by ethanol at concentrations between 2% and 20%. This effect was not affected by cimetidine or by SCH 28080, an inhibitor of the gastric hydrogen-potassium-stimulated adenosine triphosphatase. Ethanol (10%) significantly increased by 46% the tissue lactate-pyruvate ratio. The oxidations of glucose, butyrate, and acetate were progressively reduced by low concentrations of ethanol (5% and 10%). The results indicate that (a) low concentrations of ethanol and alcoholic beverages with low ethanol content are direct stimulants of acid secretion and (b) the secretory and metabolic effects of low concentrations of ethanol seem to be mediated via its oxidation.

Authors+Show Affiliations

Laboratorio de Investigaciones Gastrointestinales, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1901555

Citation

Chacín, J, et al. "Secretory and Metabolic Effects of Ethanol in the Isolated Amphibian Gastric Mucosa." Gastroenterology, vol. 100, no. 5 Pt 1, 1991, pp. 1288-95.
Chacín J, Cárdenas P, Lobo P, et al. Secretory and metabolic effects of ethanol in the isolated amphibian gastric mucosa. Gastroenterology. 1991;100(5 Pt 1):1288-95.
Chacín, J., Cárdenas, P., Lobo, P., & Hernández, I. (1991). Secretory and metabolic effects of ethanol in the isolated amphibian gastric mucosa. Gastroenterology, 100(5 Pt 1), 1288-95.
Chacín J, et al. Secretory and Metabolic Effects of Ethanol in the Isolated Amphibian Gastric Mucosa. Gastroenterology. 1991;100(5 Pt 1):1288-95. PubMed PMID: 1901555.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Secretory and metabolic effects of ethanol in the isolated amphibian gastric mucosa. AU - Chacín,J, AU - Cárdenas,P, AU - Lobo,P, AU - Hernández,I, PY - 1991/5/1/pubmed PY - 1991/5/1/medline PY - 1991/5/1/entrez SP - 1288 EP - 95 JF - Gastroenterology JO - Gastroenterology VL - 100 IS - 5 Pt 1 N2 - The effects of pure ethanol and some alcoholic beverages on acid secretion and metabolism were examined in the isolated toad gastric mucosa. Pure ethanol applied to the luminal side or to the submucosal side at low concentrations (2%-10%) was a potent stimulant of acid secretion, whereas high concentrations (greater than or equal to 20%) were inhibitory. Cimetidine and calcium-free solutions did not abolish the secretory effect of ethanol. Beer and wine, but not rum and whisky, caused a significant stimulation of acid secretion. Respiration was progressively increased by ethanol at concentrations between 2% and 20%. This effect was not affected by cimetidine or by SCH 28080, an inhibitor of the gastric hydrogen-potassium-stimulated adenosine triphosphatase. Ethanol (10%) significantly increased by 46% the tissue lactate-pyruvate ratio. The oxidations of glucose, butyrate, and acetate were progressively reduced by low concentrations of ethanol (5% and 10%). The results indicate that (a) low concentrations of ethanol and alcoholic beverages with low ethanol content are direct stimulants of acid secretion and (b) the secretory and metabolic effects of low concentrations of ethanol seem to be mediated via its oxidation. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/1901555/Secretory_and_metabolic_effects_of_ethanol_in_the_isolated_amphibian_gastric_mucosa_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0016-5085(91)70015-P DB - PRIME DP - Unbound Medicine ER -