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Metabolic Syndrome and the Risk of Ischemic Heart Disease and Stroke among Middle-Aged Japanese.
Hypertens Res 2008; 31(10):1887-94HR

Abstract

Limited information is available regarding risk of cardiovascular disease and trends for the metabolic syndrome in Asia. We examined the impact of the metabolic syndrome and its components on risk of cardiovascular disease among middle-aged Japanese according to four criteria. We followed 2,613 subjects from a rural Japanese community who participated in cardiovascular health examinations between 1990 and 1993. After 27,477 person-years of follow-up through 2003, there were 42 incidents of ischemic heart disease, 73 total strokes (54 ischemic and 18 hemorrhagic), and 115 total cases of cardiovascular disease. The metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII), American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI), International Diabetes Federation (IDF), and Japanese criteria. The multivariable hazard ratios (95%CI) associated with the metabolic syndrome based on NCEP-ATPIII criteria were 2.1 (1.1-4.0) for ischemic heart disease, 1.7 (1.0-2.7) for total stroke, 2.0 (1.2-3.5) for ischemic stroke, 1.1 (0.4-2.8) for hemorrhagic stroke, 2.0 (1.3-3.1) for ischemic cardiovascular disease, and 1.7 (1.2-2.5) for total cardiovascular disease. The population-attributable fractions of the metabolic syndrome based on NCEP-ATPIII criteria were 26-27% for ischemic heart disease and ischemic stroke and 20% for total cardiovascular disease. The metabolic syndrome based on AHA/NHLBI, IDF and Japanese criteria had weaker associations with risk of cardiovascular disease, and the association with risk of ischemic heart disease was not statistically significant. The metabolic syndrome based on NCEP-ATP III criteria predicted risks of ischemic heart disease, ischemic stroke and total cardiovascular disease, whereas that based on three other criteria predicted them less effectively.

Authors+Show Affiliations

Department of Public Health Medicine, Graduate School of Comprehensive Human Sciences, and Institute of Community Medicine, University of Tsukuba, Tsukuba, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19015596

Citation

Chei, Choy-Lye, et al. "Metabolic Syndrome and the Risk of Ischemic Heart Disease and Stroke Among Middle-Aged Japanese." Hypertension Research : Official Journal of the Japanese Society of Hypertension, vol. 31, no. 10, 2008, pp. 1887-94.
Chei CL, Yamagishi K, Tanigawa T, et al. Metabolic Syndrome and the Risk of Ischemic Heart Disease and Stroke among Middle-Aged Japanese. Hypertens Res. 2008;31(10):1887-94.
Chei, C. L., Yamagishi, K., Tanigawa, T., Kitamura, A., Imano, H., Kiyama, M., ... Iso, H. (2008). Metabolic Syndrome and the Risk of Ischemic Heart Disease and Stroke among Middle-Aged Japanese. Hypertension Research : Official Journal of the Japanese Society of Hypertension, 31(10), pp. 1887-94. doi:10.1291/hypres.31.1887.
Chei CL, et al. Metabolic Syndrome and the Risk of Ischemic Heart Disease and Stroke Among Middle-Aged Japanese. Hypertens Res. 2008;31(10):1887-94. PubMed PMID: 19015596.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic Syndrome and the Risk of Ischemic Heart Disease and Stroke among Middle-Aged Japanese. AU - Chei,Choy-Lye, AU - Yamagishi,Kazumasa, AU - Tanigawa,Takeshi, AU - Kitamura,Akihiko, AU - Imano,Hironori, AU - Kiyama,Masahiko, AU - Sato,Shinichi, AU - Iso,Hiroyasu, PY - 2008/11/19/pubmed PY - 2009/1/10/medline PY - 2008/11/19/entrez SP - 1887 EP - 94 JF - Hypertension research : official journal of the Japanese Society of Hypertension JO - Hypertens. Res. VL - 31 IS - 10 N2 - Limited information is available regarding risk of cardiovascular disease and trends for the metabolic syndrome in Asia. We examined the impact of the metabolic syndrome and its components on risk of cardiovascular disease among middle-aged Japanese according to four criteria. We followed 2,613 subjects from a rural Japanese community who participated in cardiovascular health examinations between 1990 and 1993. After 27,477 person-years of follow-up through 2003, there were 42 incidents of ischemic heart disease, 73 total strokes (54 ischemic and 18 hemorrhagic), and 115 total cases of cardiovascular disease. The metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII), American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI), International Diabetes Federation (IDF), and Japanese criteria. The multivariable hazard ratios (95%CI) associated with the metabolic syndrome based on NCEP-ATPIII criteria were 2.1 (1.1-4.0) for ischemic heart disease, 1.7 (1.0-2.7) for total stroke, 2.0 (1.2-3.5) for ischemic stroke, 1.1 (0.4-2.8) for hemorrhagic stroke, 2.0 (1.3-3.1) for ischemic cardiovascular disease, and 1.7 (1.2-2.5) for total cardiovascular disease. The population-attributable fractions of the metabolic syndrome based on NCEP-ATPIII criteria were 26-27% for ischemic heart disease and ischemic stroke and 20% for total cardiovascular disease. The metabolic syndrome based on AHA/NHLBI, IDF and Japanese criteria had weaker associations with risk of cardiovascular disease, and the association with risk of ischemic heart disease was not statistically significant. The metabolic syndrome based on NCEP-ATP III criteria predicted risks of ischemic heart disease, ischemic stroke and total cardiovascular disease, whereas that based on three other criteria predicted them less effectively. SN - 0916-9636 UR - https://www.unboundmedicine.com/medline/citation/19015596/Metabolic_Syndrome_and_the_Risk_of_Ischemic_Heart_Disease_and_Stroke_among_Middle_Aged_Japanese_ L2 - http://dx.doi.org/10.1291/hypres.31.1887 DB - PRIME DP - Unbound Medicine ER -