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Characteristics and outcome of patients with dual hepatitis B and C-associated hepatocellular carcinoma: are they different from patients with single virus infection?
Liver Int. 2009 May; 29(5):767-73.LI

Abstract

BACKGROUND

Patients with hepatocellular carcinoma (HCC) caused by dual hepatitis B and C virus (HBV, HCV) infection may constitute a distinct disease group that is different from patients with single virus infection. This study compared the clinical characteristics and outcomes of patients with HBV, HCV and dual virus infection.

METHODS

A prospective database of 1215 HCC patients with chronic hepatitis B, C or dual virus infection was investigated.

RESULTS

Patients with HCV infection (n=388) were significantly older (mean age, 69 years) than patients with dual virus (n=75, 65 years) and HBV (n=752; 60 years) infection (P<0.0001). The male-to-female ratios for the HBV, dual virus and HCV groups were 5.2, 3.4 and 1.3 respectively (P<0.0001). Patients in the HBV group more often had higher total tumour volume (mean, 409 cm(3)) than those in the dual virus group (244 cm(3)) and HCV (168 cm(3)) group (P<0.0001). No significant differences of the severity of liver cirrhosis, performance status, cancer staging and tumour cell differentiation were noted among the three groups. Patients in the HCV group had a significantly poor survival in comparison with the HBV group only in the subset of patients with small tumour volume (<50 cm(3)) in the Cox proportional hazards model (relative risk, 1.44; P=0.041).

CONCLUSIONS

Dual HBV and HCV virus infection does not accelerate the speed of HCC formation in patients with chronic hepatitis B, and appears to have a modified course of carcinogenesis pathway that is diverted away from the biological behaviour of HBV and HCV infection.

Authors+Show Affiliations

Department of Medicine, Division of Gastroenterology, Taipei Veterans General Hospital, Taipei, Taiwan. tihuo@vghtpe.gov.twNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19018974

Citation

Huo, Teh-Ia, et al. "Characteristics and Outcome of Patients With Dual Hepatitis B and C-associated Hepatocellular Carcinoma: Are They Different From Patients With Single Virus Infection?" Liver International : Official Journal of the International Association for the Study of the Liver, vol. 29, no. 5, 2009, pp. 767-73.
Huo TI, Huang YH, Hsia CY, et al. Characteristics and outcome of patients with dual hepatitis B and C-associated hepatocellular carcinoma: are they different from patients with single virus infection? Liver Int. 2009;29(5):767-73.
Huo, T. I., Huang, Y. H., Hsia, C. Y., Su, C. W., Lin, H. C., Hsu, C. Y., Lee, P. C., Lui, W. Y., Loong, C. C., Chiang, J. H., Chiou, Y. Y., & Lee, S. D. (2009). Characteristics and outcome of patients with dual hepatitis B and C-associated hepatocellular carcinoma: are they different from patients with single virus infection? Liver International : Official Journal of the International Association for the Study of the Liver, 29(5), 767-73. https://doi.org/10.1111/j.1478-3231.2008.01908.x
Huo TI, et al. Characteristics and Outcome of Patients With Dual Hepatitis B and C-associated Hepatocellular Carcinoma: Are They Different From Patients With Single Virus Infection. Liver Int. 2009;29(5):767-73. PubMed PMID: 19018974.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics and outcome of patients with dual hepatitis B and C-associated hepatocellular carcinoma: are they different from patients with single virus infection? AU - Huo,Teh-Ia, AU - Huang,Yi-Hsiang, AU - Hsia,Cheng-Yuan, AU - Su,Chien-Wei, AU - Lin,Han-Chieh, AU - Hsu,Chia-Yang, AU - Lee,Pui-Ching, AU - Lui,Wing-Yiu, AU - Loong,Che-Chuan, AU - Chiang,Jen-Huei, AU - Chiou,Yi-You, AU - Lee,Shou-Dong, Y1 - 2008/11/03/ PY - 2008/11/21/pubmed PY - 2009/8/11/medline PY - 2008/11/21/entrez SP - 767 EP - 73 JF - Liver international : official journal of the International Association for the Study of the Liver JO - Liver Int VL - 29 IS - 5 N2 - BACKGROUND: Patients with hepatocellular carcinoma (HCC) caused by dual hepatitis B and C virus (HBV, HCV) infection may constitute a distinct disease group that is different from patients with single virus infection. This study compared the clinical characteristics and outcomes of patients with HBV, HCV and dual virus infection. METHODS: A prospective database of 1215 HCC patients with chronic hepatitis B, C or dual virus infection was investigated. RESULTS: Patients with HCV infection (n=388) were significantly older (mean age, 69 years) than patients with dual virus (n=75, 65 years) and HBV (n=752; 60 years) infection (P<0.0001). The male-to-female ratios for the HBV, dual virus and HCV groups were 5.2, 3.4 and 1.3 respectively (P<0.0001). Patients in the HBV group more often had higher total tumour volume (mean, 409 cm(3)) than those in the dual virus group (244 cm(3)) and HCV (168 cm(3)) group (P<0.0001). No significant differences of the severity of liver cirrhosis, performance status, cancer staging and tumour cell differentiation were noted among the three groups. Patients in the HCV group had a significantly poor survival in comparison with the HBV group only in the subset of patients with small tumour volume (<50 cm(3)) in the Cox proportional hazards model (relative risk, 1.44; P=0.041). CONCLUSIONS: Dual HBV and HCV virus infection does not accelerate the speed of HCC formation in patients with chronic hepatitis B, and appears to have a modified course of carcinogenesis pathway that is diverted away from the biological behaviour of HBV and HCV infection. SN - 1478-3231 UR - https://www.unboundmedicine.com/medline/citation/19018974/Characteristics_and_outcome_of_patients_with_dual_hepatitis_B_and_C_associated_hepatocellular_carcinoma:_are_they_different_from_patients_with_single_virus_infection L2 - https://doi.org/10.1111/j.1478-3231.2008.01908.x DB - PRIME DP - Unbound Medicine ER -