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LRRK2 G2019S and R1441G mutations associated with Parkinson's disease are common in the Basque Country, but relative prevalence is determined by ethnicity.
Neurogenetics. 2009 Apr; 10(2):157-9.N

Abstract

Mutations in LRRK2 gene are the most frequent cause of Parkinson's disease (PD) described, but their prevalence varies between populations. Patients, 418, with PD and 138 unrelated controls from the Basque Country were screened for LRRK2 G2019S and R1441G mutations. Of the patients, 3.82% were heterozygous carriers of G2019S and 13.15% of R1441G. G2019S frequency was higher in non-Basque population (6.0%), while R1441G was more common in Basque origin population (22.4%). Our conclusion is that both G2019S and R1441G mutations' frequency varies markedly between Basque and non-Basque origin population reinforcing the importance of ethnicity consideration when establishing mutation prevalence.

Authors+Show Affiliations

Neurogenetics Laboratory, Hospital Donostia, Donostia-San Sebastián, Gipuzkoa, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19020907

Citation

Gorostidi, A, et al. "LRRK2 G2019S and R1441G Mutations Associated With Parkinson's Disease Are Common in the Basque Country, but Relative Prevalence Is Determined By Ethnicity." Neurogenetics, vol. 10, no. 2, 2009, pp. 157-9.
Gorostidi A, Ruiz-Martínez J, Lopez de Munain A, et al. LRRK2 G2019S and R1441G mutations associated with Parkinson's disease are common in the Basque Country, but relative prevalence is determined by ethnicity. Neurogenetics. 2009;10(2):157-9.
Gorostidi, A., Ruiz-Martínez, J., Lopez de Munain, A., Alzualde, A., & Martí Massó, J. F. (2009). LRRK2 G2019S and R1441G mutations associated with Parkinson's disease are common in the Basque Country, but relative prevalence is determined by ethnicity. Neurogenetics, 10(2), 157-9. https://doi.org/10.1007/s10048-008-0162-0
Gorostidi A, et al. LRRK2 G2019S and R1441G Mutations Associated With Parkinson's Disease Are Common in the Basque Country, but Relative Prevalence Is Determined By Ethnicity. Neurogenetics. 2009;10(2):157-9. PubMed PMID: 19020907.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - LRRK2 G2019S and R1441G mutations associated with Parkinson's disease are common in the Basque Country, but relative prevalence is determined by ethnicity. AU - Gorostidi,A, AU - Ruiz-Martínez,J, AU - Lopez de Munain,A, AU - Alzualde,A, AU - Martí Massó,J F, Y1 - 2008/11/20/ PY - 2008/09/26/received PY - 2008/10/29/accepted PY - 2008/11/21/pubmed PY - 2009/8/6/medline PY - 2008/11/21/entrez SP - 157 EP - 9 JF - Neurogenetics JO - Neurogenetics VL - 10 IS - 2 N2 - Mutations in LRRK2 gene are the most frequent cause of Parkinson's disease (PD) described, but their prevalence varies between populations. Patients, 418, with PD and 138 unrelated controls from the Basque Country were screened for LRRK2 G2019S and R1441G mutations. Of the patients, 3.82% were heterozygous carriers of G2019S and 13.15% of R1441G. G2019S frequency was higher in non-Basque population (6.0%), while R1441G was more common in Basque origin population (22.4%). Our conclusion is that both G2019S and R1441G mutations' frequency varies markedly between Basque and non-Basque origin population reinforcing the importance of ethnicity consideration when establishing mutation prevalence. SN - 1364-6753 UR - https://www.unboundmedicine.com/medline/citation/19020907/LRRK2_G2019S_and_R1441G_mutations_associated_with_Parkinson's_disease_are_common_in_the_Basque_Country_but_relative_prevalence_is_determined_by_ethnicity_ L2 - https://dx.doi.org/10.1007/s10048-008-0162-0 DB - PRIME DP - Unbound Medicine ER -