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The role of Dcytb in iron metabolism: an update.
Biochem Soc Trans. 2008 Dec; 36(Pt 6):1239-41.BS

Abstract

Dcytb (duodenal cytochrome b) is an iron-regulated ferric reductase highly expressed in duodenal enterocytes. Its location and strong regulation by iron has indicated it plays an important role in iron absorption. Expression of Dcytb in cells (Caco-2 and MDCK) was found to increase both ferric reductase activity and stimulate uptake of (59)Fe. An additional increase in cupric reductase activity was found in MDCK (Madin-Darby canine kidney) cells expressing Dcytb. Expression and purification of Dcytb in insect cells reveals that Dcytb is a di-haem protein and that the haems are reducible by ascorbate, indicating that ascorbate is the likely intracelluar electron donor. Studies underway in Dcytb-knockout mice reveal that Dcytb is the only iron-regulated ferric reductase in the duodenal mucosa and that loss of Dcytb affects iron absorption.

Authors+Show Affiliations

Division of Nutritional Sciences, King's College London, Franklin-Wilkins Building, London, UK. andrew.t.mckie@kcl.ac.uk

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19021532

Citation

McKie, Andrew T.. "The Role of Dcytb in Iron Metabolism: an Update." Biochemical Society Transactions, vol. 36, no. Pt 6, 2008, pp. 1239-41.
McKie AT. The role of Dcytb in iron metabolism: an update. Biochem Soc Trans. 2008;36(Pt 6):1239-41.
McKie, A. T. (2008). The role of Dcytb in iron metabolism: an update. Biochemical Society Transactions, 36(Pt 6), 1239-41. https://doi.org/10.1042/BST0361239
McKie AT. The Role of Dcytb in Iron Metabolism: an Update. Biochem Soc Trans. 2008;36(Pt 6):1239-41. PubMed PMID: 19021532.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of Dcytb in iron metabolism: an update. A1 - McKie,Andrew T, PY - 2008/11/22/pubmed PY - 2009/2/4/medline PY - 2008/11/22/entrez SP - 1239 EP - 41 JF - Biochemical Society transactions JO - Biochem Soc Trans VL - 36 IS - Pt 6 N2 - Dcytb (duodenal cytochrome b) is an iron-regulated ferric reductase highly expressed in duodenal enterocytes. Its location and strong regulation by iron has indicated it plays an important role in iron absorption. Expression of Dcytb in cells (Caco-2 and MDCK) was found to increase both ferric reductase activity and stimulate uptake of (59)Fe. An additional increase in cupric reductase activity was found in MDCK (Madin-Darby canine kidney) cells expressing Dcytb. Expression and purification of Dcytb in insect cells reveals that Dcytb is a di-haem protein and that the haems are reducible by ascorbate, indicating that ascorbate is the likely intracelluar electron donor. Studies underway in Dcytb-knockout mice reveal that Dcytb is the only iron-regulated ferric reductase in the duodenal mucosa and that loss of Dcytb affects iron absorption. SN - 1470-8752 UR - https://www.unboundmedicine.com/medline/citation/19021532/The_role_of_Dcytb_in_iron_metabolism:_an_update_ L2 - https://portlandpress.com/biochemsoctrans/article-lookup/doi/10.1042/BST0361239 DB - PRIME DP - Unbound Medicine ER -
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