Tags

Type your tag names separated by a space and hit enter

Retinopathy in type 2 diabetes mellitus is associated with increased intima-media thickness and endothelial dysfunction.
Eur J Clin Invest. 2008 Dec; 38(12):925-30.EJ

Abstract

BACKGROUND

Microangioathy and macroangiopathy in type 2 diabetes mellitus (T2DM) frequently coexist. Both types of vascular complications share traditional risk factors. It is not clear whether the presence of microangiopathy, such as diabetic retinopathy (DR), constitutes a predictor of atherosclerosis in T2DM. Here we described the search for the association between DR and intima-media thickness (IMT) in T2DM. We also compared endothelial function in subjects with and without DR.

MATERIAL AND METHODS

We examined 182 consecutive patients with T2DM for at least 5 years (mean age at examination 56.3 +/- 6.52 years). We assessed (i) IMT of carotid artery by ultrasound and (ii) endothelial function by flow-mediated dilatation (FMD) method as well as by measurement of concentrations of von Willebrand factor (vWF) and s-ICAM-1. All patients underwent ophthalmological examination. Statistical analysis included Student's, Mann-Whitney, chi-square, Fisher tests and multiple regression.

RESULTS

DR was found in 71 (39.0%) subjects. IMT was higher in patients with DR than those without DR (0.87 mm vs. 0.79 mm, respectively, P = 0.0001). FMD was lower in the complication group than in subjects without DR (8.38% vs. 10.45%, respectively, P = 0.0023). Concentrations of s-ICAM-1 and vWF were not different between the groups. In multiple regression analysis, DR was among the predictors of increased IMT (P = 0.016) and decreased FMD (P = 0.002). We did not find a significant association of DR with vWF and s-ICAM-1 (P = 0.09 and P = 0.11, respectively).

CONCLUSIONS

DR is associated with increased IMT and endothelial dysfunction in T2DM. Impaired endothelial function may be a common denominator of pathogenesis of microvascular complications and atherosclerosis in T2DM.

Authors+Show Affiliations

Department of Metabolic Diseases, Medical College, Jagiellonian University, Krakow, Poland. malecki_malecki@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19021717

Citation

Malecki, M T., et al. "Retinopathy in Type 2 Diabetes Mellitus Is Associated With Increased Intima-media Thickness and Endothelial Dysfunction." European Journal of Clinical Investigation, vol. 38, no. 12, 2008, pp. 925-30.
Malecki MT, Osmenda G, Walus-Miarka M, et al. Retinopathy in type 2 diabetes mellitus is associated with increased intima-media thickness and endothelial dysfunction. Eur J Clin Invest. 2008;38(12):925-30.
Malecki, M. T., Osmenda, G., Walus-Miarka, M., Skupien, J., Cyganek, K., Mirkiewicz-Sieradzka, B., damek-Guzik, T. A., Guzik, T. J., & Sieradzki, J. (2008). Retinopathy in type 2 diabetes mellitus is associated with increased intima-media thickness and endothelial dysfunction. European Journal of Clinical Investigation, 38(12), 925-30. https://doi.org/10.1111/j.1365-2362.2008.02051.x
Malecki MT, et al. Retinopathy in Type 2 Diabetes Mellitus Is Associated With Increased Intima-media Thickness and Endothelial Dysfunction. Eur J Clin Invest. 2008;38(12):925-30. PubMed PMID: 19021717.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retinopathy in type 2 diabetes mellitus is associated with increased intima-media thickness and endothelial dysfunction. AU - Malecki,M T, AU - Osmenda,G, AU - Walus-Miarka,M, AU - Skupien,J, AU - Cyganek,K, AU - Mirkiewicz-Sieradzka,B, AU - damek-Guzik,T A, AU - Guzik,T J, AU - Sieradzki,J, PY - 2008/11/22/pubmed PY - 2009/6/17/medline PY - 2008/11/22/entrez SP - 925 EP - 30 JF - European journal of clinical investigation JO - Eur J Clin Invest VL - 38 IS - 12 N2 - BACKGROUND: Microangioathy and macroangiopathy in type 2 diabetes mellitus (T2DM) frequently coexist. Both types of vascular complications share traditional risk factors. It is not clear whether the presence of microangiopathy, such as diabetic retinopathy (DR), constitutes a predictor of atherosclerosis in T2DM. Here we described the search for the association between DR and intima-media thickness (IMT) in T2DM. We also compared endothelial function in subjects with and without DR. MATERIAL AND METHODS: We examined 182 consecutive patients with T2DM for at least 5 years (mean age at examination 56.3 +/- 6.52 years). We assessed (i) IMT of carotid artery by ultrasound and (ii) endothelial function by flow-mediated dilatation (FMD) method as well as by measurement of concentrations of von Willebrand factor (vWF) and s-ICAM-1. All patients underwent ophthalmological examination. Statistical analysis included Student's, Mann-Whitney, chi-square, Fisher tests and multiple regression. RESULTS: DR was found in 71 (39.0%) subjects. IMT was higher in patients with DR than those without DR (0.87 mm vs. 0.79 mm, respectively, P = 0.0001). FMD was lower in the complication group than in subjects without DR (8.38% vs. 10.45%, respectively, P = 0.0023). Concentrations of s-ICAM-1 and vWF were not different between the groups. In multiple regression analysis, DR was among the predictors of increased IMT (P = 0.016) and decreased FMD (P = 0.002). We did not find a significant association of DR with vWF and s-ICAM-1 (P = 0.09 and P = 0.11, respectively). CONCLUSIONS: DR is associated with increased IMT and endothelial dysfunction in T2DM. Impaired endothelial function may be a common denominator of pathogenesis of microvascular complications and atherosclerosis in T2DM. SN - 1365-2362 UR - https://www.unboundmedicine.com/medline/citation/19021717/Retinopathy_in_type_2_diabetes_mellitus_is_associated_with_increased_intima_media_thickness_and_endothelial_dysfunction_ L2 - https://doi.org/10.1111/j.1365-2362.2008.02051.x DB - PRIME DP - Unbound Medicine ER -