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Sorbitol-fermenting enterohaemorrhagic Escherichia coli O157:H- causes another outbreak of haemolytic uraemic syndrome in children.
Epidemiol Infect. 2009 Mar; 137(3):389-95.EI

Abstract

An outbreak of haemolytic uraemic syndrome (HUS) among children caused by infection with sorbitol-fermenting enterohaemorrhagic Escherichia coli O157:H- (SF EHEC O157:H-) occurred in Germany in 2002. This pathogen has caused several outbreaks so far, yet its reservoir and routes of transmission remain unknown. SF EHEC O157:H- is easily missed as most laboratory protocols target the more common sorbitol non-fermenting strains. We performed active case-finding, extensive exploratory interviews and a case-control study. Clinical and environmental samples were screened for SF EHEC O157:H- and the isolates were subtyped by pulsed-field gel electrophoresis. We identified 38 case-patients in 11 federal states. Four case-patients died during the acute phase (case-fatality ratio 11%). The case-control study could not identify a single vehicle or source. Further studies are necessary to identify the pathogen's reservoir(s). Stool samples of patients with HUS should be tested with an adequate microbiological set-up to quickly identify SF EHEC O157:H-.

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Authors+Show Affiliations

Alpers K
Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany. alpersk@rki.de
Werber D
No affiliation info available
Frank C
No affiliation info available
Koch J
No affiliation info available
Friedrich AW
No affiliation info available
Karch H
No affiliation info available
An DER Heiden M
No affiliation info available
Prager R
No affiliation info available
Fruth A
No affiliation info available
Bielaszewska M
No affiliation info available
Morlock G
No affiliation info available
Heissenhuber A
No affiliation info available
Diedler A
No affiliation info available
Gerber A
No affiliation info available
Ammon A
No affiliation info available

MeSH

Case-Control StudiesChildChild, PreschoolDisease OutbreaksEscherichia coli O157FemaleFood ContaminationFood MicrobiologyFoodborne DiseasesGermanyHemolytic-Uremic SyndromeHumansInfantLogistic ModelsMaleSorbitol

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19021923

Citation

Alpers, K, et al. "Sorbitol-fermenting Enterohaemorrhagic Escherichia Coli O157:H- Causes Another Outbreak of Haemolytic Uraemic Syndrome in Children." Epidemiology and Infection, vol. 137, no. 3, 2009, pp. 389-95.
Alpers K, Werber D, Frank C, et al. Sorbitol-fermenting enterohaemorrhagic Escherichia coli O157:H- causes another outbreak of haemolytic uraemic syndrome in children. Epidemiol Infect. 2009;137(3):389-95.
Alpers, K., Werber, D., Frank, C., Koch, J., Friedrich, A. W., Karch, H., An DER Heiden, M., Prager, R., Fruth, A., Bielaszewska, M., Morlock, G., Heissenhuber, A., Diedler, A., Gerber, A., & Ammon, A. (2009). Sorbitol-fermenting enterohaemorrhagic Escherichia coli O157:H- causes another outbreak of haemolytic uraemic syndrome in children. Epidemiology and Infection, 137(3), 389-95. https://doi.org/10.1017/S0950268808001465
Alpers K, et al. Sorbitol-fermenting Enterohaemorrhagic Escherichia Coli O157:H- Causes Another Outbreak of Haemolytic Uraemic Syndrome in Children. Epidemiol Infect. 2009;137(3):389-95. PubMed PMID: 19021923.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sorbitol-fermenting enterohaemorrhagic Escherichia coli O157:H- causes another outbreak of haemolytic uraemic syndrome in children. AU - Alpers,K, AU - Werber,D, AU - Frank,C, AU - Koch,J, AU - Friedrich,A W, AU - Karch,H, AU - An DER Heiden,M, AU - Prager,R, AU - Fruth,A, AU - Bielaszewska,M, AU - Morlock,G, AU - Heissenhuber,A, AU - Diedler,A, AU - Gerber,A, AU - Ammon,A, Y1 - 2009/02/09/ PY - 2008/11/22/pubmed PY - 2009/4/17/medline PY - 2008/11/22/entrez SP - 389 EP - 95 JF - Epidemiology and infection JO - Epidemiol Infect VL - 137 IS - 3 N2 - An outbreak of haemolytic uraemic syndrome (HUS) among children caused by infection with sorbitol-fermenting enterohaemorrhagic Escherichia coli O157:H- (SF EHEC O157:H-) occurred in Germany in 2002. This pathogen has caused several outbreaks so far, yet its reservoir and routes of transmission remain unknown. SF EHEC O157:H- is easily missed as most laboratory protocols target the more common sorbitol non-fermenting strains. We performed active case-finding, extensive exploratory interviews and a case-control study. Clinical and environmental samples were screened for SF EHEC O157:H- and the isolates were subtyped by pulsed-field gel electrophoresis. We identified 38 case-patients in 11 federal states. Four case-patients died during the acute phase (case-fatality ratio 11%). The case-control study could not identify a single vehicle or source. Further studies are necessary to identify the pathogen's reservoir(s). Stool samples of patients with HUS should be tested with an adequate microbiological set-up to quickly identify SF EHEC O157:H-. SN - 0950-2688 UR - https://www.unboundmedicine.com/medline/citation/19021923/Sorbitol_fermenting_enterohaemorrhagic_Escherichia_coli_O157:H__causes_another_outbreak_of_haemolytic_uraemic_syndrome_in_children_ L2 - https://www.cambridge.org/core/product/identifier/S0950268808001465/type/journal_article DB - PRIME DP - Unbound Medicine ER -