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Sorbitol-fermenting enterohaemorrhagic Escherichia coli O157:H- causes another outbreak of haemolytic uraemic syndrome in children.
Epidemiol Infect. 2009 Mar; 137(3):389-95.EI

Abstract

An outbreak of haemolytic uraemic syndrome (HUS) among children caused by infection with sorbitol-fermenting enterohaemorrhagic Escherichia coli O157:H- (SF EHEC O157:H-) occurred in Germany in 2002. This pathogen has caused several outbreaks so far, yet its reservoir and routes of transmission remain unknown. SF EHEC O157:H- is easily missed as most laboratory protocols target the more common sorbitol non-fermenting strains. We performed active case-finding, extensive exploratory interviews and a case-control study. Clinical and environmental samples were screened for SF EHEC O157:H- and the isolates were subtyped by pulsed-field gel electrophoresis. We identified 38 case-patients in 11 federal states. Four case-patients died during the acute phase (case-fatality ratio 11%). The case-control study could not identify a single vehicle or source. Further studies are necessary to identify the pathogen's reservoir(s). Stool samples of patients with HUS should be tested with an adequate microbiological set-up to quickly identify SF EHEC O157:H-.

Authors+Show Affiliations

Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany. alpersk@rki.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19021923

Citation

Alpers, K, et al. "Sorbitol-fermenting Enterohaemorrhagic Escherichia Coli O157:H- Causes Another Outbreak of Haemolytic Uraemic Syndrome in Children." Epidemiology and Infection, vol. 137, no. 3, 2009, pp. 389-95.
Alpers K, Werber D, Frank C, et al. Sorbitol-fermenting enterohaemorrhagic Escherichia coli O157:H- causes another outbreak of haemolytic uraemic syndrome in children. Epidemiol Infect. 2009;137(3):389-95.
Alpers, K., Werber, D., Frank, C., Koch, J., Friedrich, A. W., Karch, H., An DER Heiden, M., Prager, R., Fruth, A., Bielaszewska, M., Morlock, G., Heissenhuber, A., Diedler, A., Gerber, A., & Ammon, A. (2009). Sorbitol-fermenting enterohaemorrhagic Escherichia coli O157:H- causes another outbreak of haemolytic uraemic syndrome in children. Epidemiology and Infection, 137(3), 389-95. https://doi.org/10.1017/S0950268808001465
Alpers K, et al. Sorbitol-fermenting Enterohaemorrhagic Escherichia Coli O157:H- Causes Another Outbreak of Haemolytic Uraemic Syndrome in Children. Epidemiol Infect. 2009;137(3):389-95. PubMed PMID: 19021923.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sorbitol-fermenting enterohaemorrhagic Escherichia coli O157:H- causes another outbreak of haemolytic uraemic syndrome in children. AU - Alpers,K, AU - Werber,D, AU - Frank,C, AU - Koch,J, AU - Friedrich,A W, AU - Karch,H, AU - An DER Heiden,M, AU - Prager,R, AU - Fruth,A, AU - Bielaszewska,M, AU - Morlock,G, AU - Heissenhuber,A, AU - Diedler,A, AU - Gerber,A, AU - Ammon,A, Y1 - 2009/02/09/ PY - 2008/11/22/pubmed PY - 2009/4/17/medline PY - 2008/11/22/entrez SP - 389 EP - 95 JF - Epidemiology and infection JO - Epidemiol Infect VL - 137 IS - 3 N2 - An outbreak of haemolytic uraemic syndrome (HUS) among children caused by infection with sorbitol-fermenting enterohaemorrhagic Escherichia coli O157:H- (SF EHEC O157:H-) occurred in Germany in 2002. This pathogen has caused several outbreaks so far, yet its reservoir and routes of transmission remain unknown. SF EHEC O157:H- is easily missed as most laboratory protocols target the more common sorbitol non-fermenting strains. We performed active case-finding, extensive exploratory interviews and a case-control study. Clinical and environmental samples were screened for SF EHEC O157:H- and the isolates were subtyped by pulsed-field gel electrophoresis. We identified 38 case-patients in 11 federal states. Four case-patients died during the acute phase (case-fatality ratio 11%). The case-control study could not identify a single vehicle or source. Further studies are necessary to identify the pathogen's reservoir(s). Stool samples of patients with HUS should be tested with an adequate microbiological set-up to quickly identify SF EHEC O157:H-. SN - 0950-2688 UR - https://www.unboundmedicine.com/medline/citation/19021923/Sorbitol_fermenting_enterohaemorrhagic_Escherichia_coli_O157:H__causes_another_outbreak_of_haemolytic_uraemic_syndrome_in_children_ L2 - https://www.cambridge.org/core/product/identifier/S0950268808001465/type/journal_article DB - PRIME DP - Unbound Medicine ER -