Tags

Type your tag names separated by a space and hit enter

Dietary n-6 and n-3 polyunsaturated fatty acids: from biochemistry to clinical implications in cardiovascular prevention.
Biochem Pharmacol. 2009 Mar 15; 77(6):937-46.BP

Abstract

Linoleic acid (LA) and alpha linolenic acid (ALA) belong to the n-6 (omega-6) and n-3 (omega-3) series of polyunsaturated fatty acids (PUFA), respectively. They are defined "essential" fatty acids since they are not synthesized in the human body and are mostly obtained from the diet. Food sources of ALA and LA are most vegetable oils, cereals and walnuts. This review critically revises the most significant epidemiological and interventional studies on the cardioprotective activity of PUFAs, linking their biological functions to biochemistry and metabolism. In fact, a complex series of desaturation and elongation reactions acting in concert transform LA and ALA to their higher unsaturated derivatives: arachidonic acid (AA) from LA, eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) from ALA. EPA and DHA are abundantly present in fish and fish oil. AA and EPA are precursors of different classes of pro-inflammatory or anti-inflammatory eicosanoids, respectively, whose biological activities have been evoked to justify risks and benefits of PUFA consumption. The controversial origin and clinical role of the n-6/n-3 ratio as a potential risk factor in cardiovascular diseases is also examined. This review highlights the important cardioprotective effect of n-3 in the secondary prevention of sudden cardiac death due to arrhythmias, but suggests caution to recommend dietary supplementation of PUFAs to the general population, without considering, at the individual level, the intake of total energy and fats.

Authors+Show Affiliations

Institute of Food Sciences, National Research Council, 83100 Avellino, Italy. glrusso@isa.cnr.it

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19022225

Citation

Russo, Gian Luigi. "Dietary N-6 and N-3 Polyunsaturated Fatty Acids: From Biochemistry to Clinical Implications in Cardiovascular Prevention." Biochemical Pharmacology, vol. 77, no. 6, 2009, pp. 937-46.
Russo GL. Dietary n-6 and n-3 polyunsaturated fatty acids: from biochemistry to clinical implications in cardiovascular prevention. Biochem Pharmacol. 2009;77(6):937-46.
Russo, G. L. (2009). Dietary n-6 and n-3 polyunsaturated fatty acids: from biochemistry to clinical implications in cardiovascular prevention. Biochemical Pharmacology, 77(6), 937-46. https://doi.org/10.1016/j.bcp.2008.10.020
Russo GL. Dietary N-6 and N-3 Polyunsaturated Fatty Acids: From Biochemistry to Clinical Implications in Cardiovascular Prevention. Biochem Pharmacol. 2009 Mar 15;77(6):937-46. PubMed PMID: 19022225.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary n-6 and n-3 polyunsaturated fatty acids: from biochemistry to clinical implications in cardiovascular prevention. A1 - Russo,Gian Luigi, Y1 - 2008/10/28/ PY - 2008/09/19/received PY - 2008/10/20/revised PY - 2008/10/21/accepted PY - 2008/11/22/pubmed PY - 2009/4/2/medline PY - 2008/11/22/entrez SP - 937 EP - 46 JF - Biochemical pharmacology JO - Biochem. Pharmacol. VL - 77 IS - 6 N2 - Linoleic acid (LA) and alpha linolenic acid (ALA) belong to the n-6 (omega-6) and n-3 (omega-3) series of polyunsaturated fatty acids (PUFA), respectively. They are defined "essential" fatty acids since they are not synthesized in the human body and are mostly obtained from the diet. Food sources of ALA and LA are most vegetable oils, cereals and walnuts. This review critically revises the most significant epidemiological and interventional studies on the cardioprotective activity of PUFAs, linking their biological functions to biochemistry and metabolism. In fact, a complex series of desaturation and elongation reactions acting in concert transform LA and ALA to their higher unsaturated derivatives: arachidonic acid (AA) from LA, eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) from ALA. EPA and DHA are abundantly present in fish and fish oil. AA and EPA are precursors of different classes of pro-inflammatory or anti-inflammatory eicosanoids, respectively, whose biological activities have been evoked to justify risks and benefits of PUFA consumption. The controversial origin and clinical role of the n-6/n-3 ratio as a potential risk factor in cardiovascular diseases is also examined. This review highlights the important cardioprotective effect of n-3 in the secondary prevention of sudden cardiac death due to arrhythmias, but suggests caution to recommend dietary supplementation of PUFAs to the general population, without considering, at the individual level, the intake of total energy and fats. SN - 1873-2968 UR - https://www.unboundmedicine.com/medline/citation/19022225/Dietary_n_6_and_n_3_polyunsaturated_fatty_acids:_from_biochemistry_to_clinical_implications_in_cardiovascular_prevention_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-2952(08)00777-6 DB - PRIME DP - Unbound Medicine ER -