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Complexity of neural mechanisms underlying overconsumption of sugar in scheduled feeding: involvement of opioids, orexin, oxytocin and NPY.
Peptides. 2009 Feb; 30(2):226-33.P

Abstract

A regular daily meal regimen, as opposed to ad libitum consumption, enforces eating at a predefined time and within a short timeframe. Hence, it is important to study food intake regulation in animal feeding models that somewhat reflect this pattern. We investigated the effect of scheduled feeding on the intake of a palatable, high-sugar diet in rats and attempted to define central mechanisms - especially those related to opioid signaling--responsible for overeating sweet foods under such conditions. We found that scheduled access to food, even as challenging as 20 min per day, does not prevent overconsumption of a high-sucrose diet compared to a standard one. An opioid receptor antagonist, naloxone, at 0.3-1 mg/kg b. wt., decreased the intake of the sweet diet, whereas higher doses were required to reduce bland food consumption. Real-time PCR analysis revealed that expression of hypothalamic and brainstem genes encoding opioid peptides and receptors did not differ in sucrose versus regular diet-fed rats, which suggests that scheduled intake of sweet food produces only a transient change in the opioid tone. Intake of sugar was also associated with upregulation of orexin and oxytocin genes in the hypothalamus and NPY in the brainstem. We conclude that scheduled consumption of sugar diets is associated with activity of a complex network of neuroregulators involving opioids, orexin, oxytocin and NPY.

Authors+Show Affiliations

Department of Neuroscience, Functional Pharmacology, Uppsala University, BMC, Uppsala SE 75124, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19022308

Citation

Olszewski, Pawel K., et al. "Complexity of Neural Mechanisms Underlying Overconsumption of Sugar in Scheduled Feeding: Involvement of Opioids, Orexin, Oxytocin and NPY." Peptides, vol. 30, no. 2, 2009, pp. 226-33.
Olszewski PK, Shaw TJ, Grace MK, et al. Complexity of neural mechanisms underlying overconsumption of sugar in scheduled feeding: involvement of opioids, orexin, oxytocin and NPY. Peptides. 2009;30(2):226-33.
Olszewski, P. K., Shaw, T. J., Grace, M. K., Höglund, C. E., Fredriksson, R., Schiöth, H. B., & Levine, A. S. (2009). Complexity of neural mechanisms underlying overconsumption of sugar in scheduled feeding: involvement of opioids, orexin, oxytocin and NPY. Peptides, 30(2), 226-33. https://doi.org/10.1016/j.peptides.2008.10.011
Olszewski PK, et al. Complexity of Neural Mechanisms Underlying Overconsumption of Sugar in Scheduled Feeding: Involvement of Opioids, Orexin, Oxytocin and NPY. Peptides. 2009;30(2):226-33. PubMed PMID: 19022308.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Complexity of neural mechanisms underlying overconsumption of sugar in scheduled feeding: involvement of opioids, orexin, oxytocin and NPY. AU - Olszewski,Pawel K, AU - Shaw,Timothy J, AU - Grace,Martha K, AU - Höglund,Catherine E, AU - Fredriksson,Robert, AU - Schiöth,Helgi B, AU - Levine,Allen S, Y1 - 2008/10/30/ PY - 2008/09/21/received PY - 2008/10/19/revised PY - 2008/10/20/accepted PY - 2008/11/22/entrez PY - 2008/11/22/pubmed PY - 2009/5/8/medline SP - 226 EP - 33 JF - Peptides JO - Peptides VL - 30 IS - 2 N2 - A regular daily meal regimen, as opposed to ad libitum consumption, enforces eating at a predefined time and within a short timeframe. Hence, it is important to study food intake regulation in animal feeding models that somewhat reflect this pattern. We investigated the effect of scheduled feeding on the intake of a palatable, high-sugar diet in rats and attempted to define central mechanisms - especially those related to opioid signaling--responsible for overeating sweet foods under such conditions. We found that scheduled access to food, even as challenging as 20 min per day, does not prevent overconsumption of a high-sucrose diet compared to a standard one. An opioid receptor antagonist, naloxone, at 0.3-1 mg/kg b. wt., decreased the intake of the sweet diet, whereas higher doses were required to reduce bland food consumption. Real-time PCR analysis revealed that expression of hypothalamic and brainstem genes encoding opioid peptides and receptors did not differ in sucrose versus regular diet-fed rats, which suggests that scheduled intake of sweet food produces only a transient change in the opioid tone. Intake of sugar was also associated with upregulation of orexin and oxytocin genes in the hypothalamus and NPY in the brainstem. We conclude that scheduled consumption of sugar diets is associated with activity of a complex network of neuroregulators involving opioids, orexin, oxytocin and NPY. SN - 0196-9781 UR - https://www.unboundmedicine.com/medline/citation/19022308/Complexity_of_neural_mechanisms_underlying_overconsumption_of_sugar_in_scheduled_feeding:_involvement_of_opioids_orexin_oxytocin_and_NPY_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0196-9781(08)00450-6 DB - PRIME DP - Unbound Medicine ER -