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Possible role of sertraline against 3-nitropropionic acid induced behavioral, oxidative stress and mitochondrial dysfunctions in rat brain.
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Feb 01; 33(1):100-8.PN

Abstract

Oxidative stress and disrupted energy metabolism are major events leading to nerve cell death. Oxidative stress and related reactive oxygen species is one of the common cooperative sharing pathways involved in neurodegenerative disorders including Huntington's disease. The present study evaluated the possible role of sertraline on the 3-nitropropionic acid induced behavioral, biochemical, and mitochondrial alterations in discrete areas of rat brain. 3-Nitropropionic acid (10 mg/kg) administration for 14 days significantly induced Huntington's disease like symptoms in rats as indicated by change in locomotor activity, body weight, rotarod activity performance, oxidative damage (elevated levels of lipid peroxidation, nitrite concentration, depletion of antioxidant enzyme levels) and mitochondrial dysfunction (Complexes-I, II, II and IV) in striatum, cortex and hippocampal region of brain. Treatment with sertraline (5 and 10 mg/kg) significantly reversed behavioral, biochemical and mitochondrial enzyme dysfunctions in 3-nitropropionic acid treated group. Further, combination of yohimbine (2 mg/kg) (non selective serotonin with the higher dose of sertraline (10 mg/kg) did not influence the protective action of sertraline. The present study suggests the possible antioxidant role of sertraline against 3-nitropropionic acid induced alterations in animals.

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Authors+Show Affiliations

Kumar P
Pharmacology division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India.
Kumar A
No affiliation info available

MeSH

AnimalsAntioxidantsBody WeightBrainCerebral CortexCorpus StriatumHippocampusMaleMitochondriaMotor ActivityNitro CompoundsOxidative StressPropionatesRatsRats, WistarReactive Oxygen SpeciesRotarod Performance TestSertralineYohimbine

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19022325

Citation

Kumar, Puneet, and Anil Kumar. "Possible Role of Sertraline Against 3-nitropropionic Acid Induced Behavioral, Oxidative Stress and Mitochondrial Dysfunctions in Rat Brain." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 33, no. 1, 2009, pp. 100-8.
Kumar P, Kumar A. Possible role of sertraline against 3-nitropropionic acid induced behavioral, oxidative stress and mitochondrial dysfunctions in rat brain. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33(1):100-8.
Kumar, P., & Kumar, A. (2009). Possible role of sertraline against 3-nitropropionic acid induced behavioral, oxidative stress and mitochondrial dysfunctions in rat brain. Progress in Neuro-psychopharmacology & Biological Psychiatry, 33(1), 100-8. https://doi.org/10.1016/j.pnpbp.2008.10.013
Kumar P, Kumar A. Possible Role of Sertraline Against 3-nitropropionic Acid Induced Behavioral, Oxidative Stress and Mitochondrial Dysfunctions in Rat Brain. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Feb 1;33(1):100-8. PubMed PMID: 19022325.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Possible role of sertraline against 3-nitropropionic acid induced behavioral, oxidative stress and mitochondrial dysfunctions in rat brain. AU - Kumar,Puneet, AU - Kumar,Anil, Y1 - 2008/10/31/ PY - 2008/07/17/received PY - 2008/10/21/revised PY - 2008/10/21/accepted PY - 2008/11/22/pubmed PY - 2009/4/3/medline PY - 2008/11/22/entrez SP - 100 EP - 8 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 33 IS - 1 N2 - Oxidative stress and disrupted energy metabolism are major events leading to nerve cell death. Oxidative stress and related reactive oxygen species is one of the common cooperative sharing pathways involved in neurodegenerative disorders including Huntington's disease. The present study evaluated the possible role of sertraline on the 3-nitropropionic acid induced behavioral, biochemical, and mitochondrial alterations in discrete areas of rat brain. 3-Nitropropionic acid (10 mg/kg) administration for 14 days significantly induced Huntington's disease like symptoms in rats as indicated by change in locomotor activity, body weight, rotarod activity performance, oxidative damage (elevated levels of lipid peroxidation, nitrite concentration, depletion of antioxidant enzyme levels) and mitochondrial dysfunction (Complexes-I, II, II and IV) in striatum, cortex and hippocampal region of brain. Treatment with sertraline (5 and 10 mg/kg) significantly reversed behavioral, biochemical and mitochondrial enzyme dysfunctions in 3-nitropropionic acid treated group. Further, combination of yohimbine (2 mg/kg) (non selective serotonin with the higher dose of sertraline (10 mg/kg) did not influence the protective action of sertraline. The present study suggests the possible antioxidant role of sertraline against 3-nitropropionic acid induced alterations in animals. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/19022325/Possible_role_of_sertraline_against_3_nitropropionic_acid_induced_behavioral_oxidative_stress_and_mitochondrial_dysfunctions_in_rat_brain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(08)00319-9 DB - PRIME DP - Unbound Medicine ER -
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