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Chlorogenic acids from green coffee extract are highly bioavailable in humans.
J Nutr. 2008 Dec; 138(12):2309-15.JN

Abstract

Chlorogenic acids (CGA) are cinnamic acid derivatives with biological effects mostly related to their antioxidant and antiinflammatory activities. Caffeoylquinic acids (CQA) and dicaffeoylquinic acids (diCQA) are the main CGA found in nature. Because green coffee is a major source of CGA, it has been used for production of nutraceuticals. However, data on the bioavailability of CGA from green coffee in humans are inexistent. The present study evaluated the pharmacokinetic profile and apparent bioavailability of CGA in plasma and urine of 10 healthy adults for 8 h after the consumption of a decaffeinated green coffee extract containing 170 mg of CGA. Three CQA, 3 diCQA, and caffeic, ferulic, isoferulic, and p-coumaric acids were identified in plasma by HPLC-Diode Array Detector-MS after treatment. Over 30% (33.1 +/- 23.1%) of the ingested cinnamic acid moieties were recovered in plasma, including metabolites, with peak levels from 0.5 to 8 h after treatment. CGA and metabolites identified in urine after treatment were 4-CQA, 5-CQA, and sinapic, p-hydroxybenzoic, gallic, vanillic, dihydrocaffeic, caffeic, ferulic, isoferulic, and p-coumaric acids, totaling 5.5 +/- 10.6% urinary recovery of the ingested cinnamic and quinic acid moiteties. This study shows that the major CGA compounds present in green coffee are highly absorbed and metabolized in humans.

Authors+Show Affiliations

Departamento de Bioquímica, Laboratório de Bioquímica Nutricional e de Alimentos, Instituto de Química, Universidade Federal do Rio de Janeiro, Ilha do Fundão, RJ, Brazil. afarah@iq.ufrj.brNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19022950

Citation

Farah, Adriana, et al. "Chlorogenic Acids From Green Coffee Extract Are Highly Bioavailable in Humans." The Journal of Nutrition, vol. 138, no. 12, 2008, pp. 2309-15.
Farah A, Monteiro M, Donangelo CM, et al. Chlorogenic acids from green coffee extract are highly bioavailable in humans. J Nutr. 2008;138(12):2309-15.
Farah, A., Monteiro, M., Donangelo, C. M., & Lafay, S. (2008). Chlorogenic acids from green coffee extract are highly bioavailable in humans. The Journal of Nutrition, 138(12), 2309-15. https://doi.org/10.3945/jn.108.095554
Farah A, et al. Chlorogenic Acids From Green Coffee Extract Are Highly Bioavailable in Humans. J Nutr. 2008;138(12):2309-15. PubMed PMID: 19022950.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chlorogenic acids from green coffee extract are highly bioavailable in humans. AU - Farah,Adriana, AU - Monteiro,Mariana, AU - Donangelo,Carmen M, AU - Lafay,Sophie, PY - 2008/11/22/pubmed PY - 2009/1/7/medline PY - 2008/11/22/entrez SP - 2309 EP - 15 JF - The Journal of nutrition JO - J. Nutr. VL - 138 IS - 12 N2 - Chlorogenic acids (CGA) are cinnamic acid derivatives with biological effects mostly related to their antioxidant and antiinflammatory activities. Caffeoylquinic acids (CQA) and dicaffeoylquinic acids (diCQA) are the main CGA found in nature. Because green coffee is a major source of CGA, it has been used for production of nutraceuticals. However, data on the bioavailability of CGA from green coffee in humans are inexistent. The present study evaluated the pharmacokinetic profile and apparent bioavailability of CGA in plasma and urine of 10 healthy adults for 8 h after the consumption of a decaffeinated green coffee extract containing 170 mg of CGA. Three CQA, 3 diCQA, and caffeic, ferulic, isoferulic, and p-coumaric acids were identified in plasma by HPLC-Diode Array Detector-MS after treatment. Over 30% (33.1 +/- 23.1%) of the ingested cinnamic acid moieties were recovered in plasma, including metabolites, with peak levels from 0.5 to 8 h after treatment. CGA and metabolites identified in urine after treatment were 4-CQA, 5-CQA, and sinapic, p-hydroxybenzoic, gallic, vanillic, dihydrocaffeic, caffeic, ferulic, isoferulic, and p-coumaric acids, totaling 5.5 +/- 10.6% urinary recovery of the ingested cinnamic and quinic acid moiteties. This study shows that the major CGA compounds present in green coffee are highly absorbed and metabolized in humans. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/19022950/Chlorogenic_acids_from_green_coffee_extract_are_highly_bioavailable_in_humans_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.108.095554 DB - PRIME DP - Unbound Medicine ER -