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Enhanced dissolution of ibuprofen using solid dispersion with poloxamer 407.
Arch Pharm Res. 2008 Nov; 31(11):1497-507.AP

Abstract

To improve its dissolution, ibuprofen solid dispersions (SDs) were prepared, characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR), and evaluated for solubility, and in-vitro ibuprofen release. Loss of individual surface properties during melting and re-solidification as revealed by SEM micrographs indicated the formation of effective SDs. Absence or shifting towards the lower melting temperature of the drug peak in SDs and physical mixtures in DSC study indicated the possibilities of drug-polymer interactions. FTIR spectra showed the presence of drug crystalline in SDs. The effect of improved dissolution on the oral absorption of ibuprofen in rats was also studied. Quicker release of ibuprofen from SDs in rat intestine resulted in a significant increase in AUC and C(max), and a significant decrease in T(max) over pure ibuprofen. Comparison of the enhanced solubility, dissolution, AUC, and C(max) of ibuprofen from different poloxamers suggested that the preparation of ibuprofen SDs using P 407 as a meltable hydrophilic polymer carrier could be a promising approach to improve its solubility, dissolution and absorption rate.

Authors+Show Affiliations

College of Pharmacy, Yeungnam University, Gyongsan 712-749, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19023548

Citation

Newa, Madhuri, et al. "Enhanced Dissolution of Ibuprofen Using Solid Dispersion With Poloxamer 407." Archives of Pharmacal Research, vol. 31, no. 11, 2008, pp. 1497-507.
Newa M, Bhandari KH, Oh DH, et al. Enhanced dissolution of ibuprofen using solid dispersion with poloxamer 407. Arch Pharm Res. 2008;31(11):1497-507.
Newa, M., Bhandari, K. H., Oh, D. H., Kim, Y. R., Sung, J. H., Kim, J. O., Woo, J. S., Choi, H. G., & Yong, C. S. (2008). Enhanced dissolution of ibuprofen using solid dispersion with poloxamer 407. Archives of Pharmacal Research, 31(11), 1497-507. https://doi.org/10.1007/s12272-001-2136-8
Newa M, et al. Enhanced Dissolution of Ibuprofen Using Solid Dispersion With Poloxamer 407. Arch Pharm Res. 2008;31(11):1497-507. PubMed PMID: 19023548.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhanced dissolution of ibuprofen using solid dispersion with poloxamer 407. AU - Newa,Madhuri, AU - Bhandari,Krishna Hari, AU - Oh,Dong Hoon, AU - Kim,Young Ran, AU - Sung,Joon Ho, AU - Kim,Jong Oh, AU - Woo,Jong Soo, AU - Choi,Han Gon, AU - Yong,Chul Soon, Y1 - 2008/11/21/ PY - 2007/12/26/received PY - 2008/11/07/accepted PY - 2008/11/07/revised PY - 2008/11/22/pubmed PY - 2009/1/6/medline PY - 2008/11/22/entrez SP - 1497 EP - 507 JF - Archives of pharmacal research JO - Arch Pharm Res VL - 31 IS - 11 N2 - To improve its dissolution, ibuprofen solid dispersions (SDs) were prepared, characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR), and evaluated for solubility, and in-vitro ibuprofen release. Loss of individual surface properties during melting and re-solidification as revealed by SEM micrographs indicated the formation of effective SDs. Absence or shifting towards the lower melting temperature of the drug peak in SDs and physical mixtures in DSC study indicated the possibilities of drug-polymer interactions. FTIR spectra showed the presence of drug crystalline in SDs. The effect of improved dissolution on the oral absorption of ibuprofen in rats was also studied. Quicker release of ibuprofen from SDs in rat intestine resulted in a significant increase in AUC and C(max), and a significant decrease in T(max) over pure ibuprofen. Comparison of the enhanced solubility, dissolution, AUC, and C(max) of ibuprofen from different poloxamers suggested that the preparation of ibuprofen SDs using P 407 as a meltable hydrophilic polymer carrier could be a promising approach to improve its solubility, dissolution and absorption rate. SN - 0253-6269 UR - https://www.unboundmedicine.com/medline/citation/19023548/Enhanced_dissolution_of_ibuprofen_using_solid_dispersion_with_poloxamer_407_ L2 - https://dx.doi.org/10.1007/s12272-001-2136-8 DB - PRIME DP - Unbound Medicine ER -