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Bioactivity and chemistry of the genus Hortonia.
Nat Prod Res. 2008; 22(16):1393-402.NP

Abstract

The dichloromethane extracts of the leaves, stem bark, bark and the roots of the three species of the primitive endemic genus Hortonia, H. angustifolia, H. floribunda and H. ovalifolia, collected from nine geographical locations ranging from lower elevations (84-420 m) to higher (2000 m) showed comparable HPLC profiles and mosquito larvicidal and antifungal activities; protein analysis of the leaves of the three species of Hortonia showed identical peaks and bands. The two major metabolites (4S)-4-methyl-2-(11-dodecynyl)-2-butenolide (2) and (4S)-4-methyl-2-(11-dodecenyl)-2-butenolide (3), which were previously reported from all three plants, showed potent larvicidal activities. Compound 2 was excessively high in the extracts of the stem bark and the roots of all three species amounting to approximately 38 and 60%, respectively. A minor new butenolide (4), (4S)-4-methyl-2-((2R)-hydroxy-11-dodecenyl)-2-butenolide, with much reduced larvicidal activity and ishwarane (1), which showed antifungal activity, were also isolated from all three plants. Treatment of compound 2 with H(2)/Pd-C afforded the completely reduced compound 5, which showed no larvicidal activity, indicating that unsaturation in both 2 and 3 is necessary for their bioactivity. The foregoing evidence showed that there are major similarities between the three species of Hortonia.

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Authors+Show Affiliations

Ratnayake R
Department of Chemistry, University of Peradeniya, Peradeniya, Sri Lanka.
Ratnayake Bandara BM
No affiliation info available
Wijesundara S
No affiliation info available
Macleod JK
No affiliation info available
Simmonds P
No affiliation info available
Karunaratne V
No affiliation info available

MeSH

4-ButyrolactoneAnimalsAntifungal AgentsCladosporiumCulicidaeLarvaMonimiaceaeMosquito ControlPlant BarkPlant LeavesPlant RootsSri LankaStructure-Activity Relationship

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

19023800

Citation

Ratnayake, Rukmal, et al. "Bioactivity and Chemistry of the Genus Hortonia." Natural Product Research, vol. 22, no. 16, 2008, pp. 1393-402.
Ratnayake R, Ratnayake Bandara BM, Wijesundara S, et al. Bioactivity and chemistry of the genus Hortonia. Nat Prod Res. 2008;22(16):1393-402.
Ratnayake, R., Ratnayake Bandara, B. M., Wijesundara, S., Macleod, J. K., Simmonds, P., & Karunaratne, V. (2008). Bioactivity and chemistry of the genus Hortonia. Natural Product Research, 22(16), 1393-402. https://doi.org/10.1080/14786410701722433
Ratnayake R, et al. Bioactivity and Chemistry of the Genus Hortonia. Nat Prod Res. 2008;22(16):1393-402. PubMed PMID: 19023800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioactivity and chemistry of the genus Hortonia. AU - Ratnayake,Rukmal, AU - Ratnayake Bandara,B M, AU - Wijesundara,Siril, AU - Macleod,John K, AU - Simmonds,Peta, AU - Karunaratne,Veranja, PY - 2008/11/22/pubmed PY - 2008/12/20/medline PY - 2008/11/22/entrez SP - 1393 EP - 402 JF - Natural product research JO - Nat Prod Res VL - 22 IS - 16 N2 - The dichloromethane extracts of the leaves, stem bark, bark and the roots of the three species of the primitive endemic genus Hortonia, H. angustifolia, H. floribunda and H. ovalifolia, collected from nine geographical locations ranging from lower elevations (84-420 m) to higher (2000 m) showed comparable HPLC profiles and mosquito larvicidal and antifungal activities; protein analysis of the leaves of the three species of Hortonia showed identical peaks and bands. The two major metabolites (4S)-4-methyl-2-(11-dodecynyl)-2-butenolide (2) and (4S)-4-methyl-2-(11-dodecenyl)-2-butenolide (3), which were previously reported from all three plants, showed potent larvicidal activities. Compound 2 was excessively high in the extracts of the stem bark and the roots of all three species amounting to approximately 38 and 60%, respectively. A minor new butenolide (4), (4S)-4-methyl-2-((2R)-hydroxy-11-dodecenyl)-2-butenolide, with much reduced larvicidal activity and ishwarane (1), which showed antifungal activity, were also isolated from all three plants. Treatment of compound 2 with H(2)/Pd-C afforded the completely reduced compound 5, which showed no larvicidal activity, indicating that unsaturation in both 2 and 3 is necessary for their bioactivity. The foregoing evidence showed that there are major similarities between the three species of Hortonia. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/19023800/Bioactivity_and_chemistry_of_the_genus_Hortonia_ L2 - https://www.tandfonline.com/doi/full/10.1080/14786410701722433 DB - PRIME DP - Unbound Medicine ER -