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Human bocavirus in children suffering from acute lower respiratory tract infection in Beijing Children's Hospital.
Chin Med J (Engl). 2008 Sep 05; 121(17):1607-10.CM

Abstract

BACKGROUND

Human bocavirus (HBoV) is a parvovirus recently found to possibly cause respiratory tract disease in children and adults. This study investigated HBoV infection and its clinical characteristics in children younger than five years of age suffering from acute lower respiratory tract infection in Beijing Children's Hospital.

METHODS

Nasopharyngeal aspirates were collected from children suffering from acute lower respiratory tract infection during the winters of 2004 to 2006 (from November through the following February). HBoV was detected by polymerase chain reaction amplification and virus isolation and the amplification products were sequenced for identification.

RESULTS

HBoV infection was detected in 16 of 333 study subjects. Coinfections with respiratory syncytial virus were detected in 3 of 16 HBoV positive patients with acute lower respiratory tract infection. The median age for HBoV positive children was 8 months (mean age, 17 months; range, 3 to 57 months). Among the HBoV positive children, 14 were younger than 3 years old, 9 were younger than 1 year old and 7 were younger than 6 months. These 16 positive HBoV children exhibited coughing and abnormal chest radiography findings and more than 60% of these children had wheezing and fever. Ten children were clinically diagnosed with pneumonia, 2 bronchiolitis, 2 acute bronchitis and 2 asthma. One child died.

CONCLUSIONS

HBoV was detected in about 5% of children with acute lower respiratory infection seen in Beijing Children's Hospital. Further investigations regarding clinical and epidemiologic characteristics of HBoV infection are needed.

Authors+Show Affiliations

Virus Laboratory, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19024084

Citation

Zhang, Li-Li, et al. "Human Bocavirus in Children Suffering From Acute Lower Respiratory Tract Infection in Beijing Children's Hospital." Chinese Medical Journal, vol. 121, no. 17, 2008, pp. 1607-10.
Zhang LL, Tang LY, Xie ZD, et al. Human bocavirus in children suffering from acute lower respiratory tract infection in Beijing Children's Hospital. Chin Med J (Engl). 2008;121(17):1607-10.
Zhang, L. L., Tang, L. Y., Xie, Z. D., Tan, X. J., Li, C. S., Cui, A. L., Ji, Y. X., Xu, S. T., Mao, N. Y., Xu, W. B., & Shen, K. L. (2008). Human bocavirus in children suffering from acute lower respiratory tract infection in Beijing Children's Hospital. Chinese Medical Journal, 121(17), 1607-10.
Zhang LL, et al. Human Bocavirus in Children Suffering From Acute Lower Respiratory Tract Infection in Beijing Children's Hospital. Chin Med J (Engl). 2008 Sep 5;121(17):1607-10. PubMed PMID: 19024084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human bocavirus in children suffering from acute lower respiratory tract infection in Beijing Children's Hospital. AU - Zhang,Li-Li, AU - Tang,Liu-Ying, AU - Xie,Zheng-De, AU - Tan,Xiao-Juan, AU - Li,Chong-Shan, AU - Cui,Ai-Li, AU - Ji,Yi-Xin, AU - Xu,Song-Tao, AU - Mao,Nai-Ying, AU - Xu,Wen-Bo, AU - Shen,Kun-Ling, PY - 2008/11/26/pubmed PY - 2008/12/17/medline PY - 2008/11/26/entrez SP - 1607 EP - 10 JF - Chinese medical journal JO - Chin Med J (Engl) VL - 121 IS - 17 N2 - BACKGROUND: Human bocavirus (HBoV) is a parvovirus recently found to possibly cause respiratory tract disease in children and adults. This study investigated HBoV infection and its clinical characteristics in children younger than five years of age suffering from acute lower respiratory tract infection in Beijing Children's Hospital. METHODS: Nasopharyngeal aspirates were collected from children suffering from acute lower respiratory tract infection during the winters of 2004 to 2006 (from November through the following February). HBoV was detected by polymerase chain reaction amplification and virus isolation and the amplification products were sequenced for identification. RESULTS: HBoV infection was detected in 16 of 333 study subjects. Coinfections with respiratory syncytial virus were detected in 3 of 16 HBoV positive patients with acute lower respiratory tract infection. The median age for HBoV positive children was 8 months (mean age, 17 months; range, 3 to 57 months). Among the HBoV positive children, 14 were younger than 3 years old, 9 were younger than 1 year old and 7 were younger than 6 months. These 16 positive HBoV children exhibited coughing and abnormal chest radiography findings and more than 60% of these children had wheezing and fever. Ten children were clinically diagnosed with pneumonia, 2 bronchiolitis, 2 acute bronchitis and 2 asthma. One child died. CONCLUSIONS: HBoV was detected in about 5% of children with acute lower respiratory infection seen in Beijing Children's Hospital. Further investigations regarding clinical and epidemiologic characteristics of HBoV infection are needed. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/19024084/Human_bocavirus_in_children_suffering_from_acute_lower_respiratory_tract_infection_in_Beijing_Children's_Hospital_ L2 - https://Insights.ovid.com/pubmed?pmid=19024084 DB - PRIME DP - Unbound Medicine ER -