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Antibiotic susceptibility of pathogens isolated from patients with community-acquired respiratory tract infections in Pakistan--the active study.
J Ayub Med Coll Abbottabad. 2008 Jan-Mar; 20(1):7-9.JA

Abstract

BACKGROUND

Respiratory tract infections (RTIs) are amongst the most wide spread and serious infections, accounting for over 50 million deaths globally each year. In developing countries, infants under 4 years of age are at greatest risk of lower RTIs, whereas in developed countries the severity of infection and rate of mortality are greater in elderly. The objective of the survey was to determine the in vitro susceptibility of antibiotics commonly prescribed RTIs against Streptococcus pneumoniae (SP), Haemophilus influenzae (HI) and Streptococcus pyogenes, isolated from patients with community-acquired RTIs globally. This survey involved 9 countries. In this study we present the results from Pakistan where SP and HI only were tested.

METHODS

A total of 200 isolates were included in the study. Both SP and HI were in equal number. Antibiotic susceptibility testing was performed by using Clinical and Laboratory Standards Institute guidelines and E test for determination of the minimal inhibitory concentration. For non-US products the Committee of the Antibiogram of the French Society of Microbiology Breakpoints was used.

RESULTS

All SP were found susceptible to amoxicillin, co-amoxiclave and cefixime, 72% isolates were found sensitive to macrolide and 97% to levofloxacin. All HI were found sensitive to co-amoxiclave and to cefixime, 97% to ampicillin, 98% to clarithromycin and 99% to levofloxacin.

CONCLUSION

In isolates collected from Pakistan, SP resistance rate was elevated for macrolide. SP and HI remain susceptible to beta-lactams as well as to levofloxacin.

Authors+Show Affiliations

Department of Pathology and Microbiology, The Aga Khan University, Karachi, Pakistan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19024175

Citation

Zafar, Afia, et al. "Antibiotic Susceptibility of Pathogens Isolated From Patients With Community-acquired Respiratory Tract Infections in Pakistan--the Active Study." Journal of Ayub Medical College, Abbottabad : JAMC, vol. 20, no. 1, 2008, pp. 7-9.
Zafar A, Hussain Z, Lomama E, et al. Antibiotic susceptibility of pathogens isolated from patients with community-acquired respiratory tract infections in Pakistan--the active study. J Ayub Med Coll Abbottabad. 2008;20(1):7-9.
Zafar, A., Hussain, Z., Lomama, E., Sibille, S., Irfan, S., & Khan, E. (2008). Antibiotic susceptibility of pathogens isolated from patients with community-acquired respiratory tract infections in Pakistan--the active study. Journal of Ayub Medical College, Abbottabad : JAMC, 20(1), 7-9.
Zafar A, et al. Antibiotic Susceptibility of Pathogens Isolated From Patients With Community-acquired Respiratory Tract Infections in Pakistan--the Active Study. J Ayub Med Coll Abbottabad. 2008 Jan-Mar;20(1):7-9. PubMed PMID: 19024175.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibiotic susceptibility of pathogens isolated from patients with community-acquired respiratory tract infections in Pakistan--the active study. AU - Zafar,Afia, AU - Hussain,Zahid, AU - Lomama,Eale, AU - Sibille,Sophie, AU - Irfan,Seema, AU - Khan,Erum, PY - 2008/11/26/pubmed PY - 2009/1/8/medline PY - 2008/11/26/entrez SP - 7 EP - 9 JF - Journal of Ayub Medical College, Abbottabad : JAMC JO - J Ayub Med Coll Abbottabad VL - 20 IS - 1 N2 - BACKGROUND: Respiratory tract infections (RTIs) are amongst the most wide spread and serious infections, accounting for over 50 million deaths globally each year. In developing countries, infants under 4 years of age are at greatest risk of lower RTIs, whereas in developed countries the severity of infection and rate of mortality are greater in elderly. The objective of the survey was to determine the in vitro susceptibility of antibiotics commonly prescribed RTIs against Streptococcus pneumoniae (SP), Haemophilus influenzae (HI) and Streptococcus pyogenes, isolated from patients with community-acquired RTIs globally. This survey involved 9 countries. In this study we present the results from Pakistan where SP and HI only were tested. METHODS: A total of 200 isolates were included in the study. Both SP and HI were in equal number. Antibiotic susceptibility testing was performed by using Clinical and Laboratory Standards Institute guidelines and E test for determination of the minimal inhibitory concentration. For non-US products the Committee of the Antibiogram of the French Society of Microbiology Breakpoints was used. RESULTS: All SP were found susceptible to amoxicillin, co-amoxiclave and cefixime, 72% isolates were found sensitive to macrolide and 97% to levofloxacin. All HI were found sensitive to co-amoxiclave and to cefixime, 97% to ampicillin, 98% to clarithromycin and 99% to levofloxacin. CONCLUSION: In isolates collected from Pakistan, SP resistance rate was elevated for macrolide. SP and HI remain susceptible to beta-lactams as well as to levofloxacin. SN - 1025-9589 UR - https://www.unboundmedicine.com/medline/citation/19024175/Antibiotic_susceptibility_of_pathogens_isolated_from_patients_with_community_acquired_respiratory_tract_infections_in_Pakistan__the_active_study_ L2 - https://medlineplus.gov/antibioticresistance.html DB - PRIME DP - Unbound Medicine ER -