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[Helicobacter pylori infection and gastric cardia cancer: a nested case-control study].
Zhonghua Zhong Liu Za Zhi 2008; 30(6):428-31ZZ

Abstract

OBJECTIVE

To explore the association of Helicobacter pylori infection with gastric cardia cancer.

METHODS

An unmatched prospective nested case-control study was conducted. In 1985, 29 584 subjects in age of 40-69 were recruited from Linxian, Henan Province. 10 mL blood samples were collected from all participants. By March 2001, 1089 cases of gastric cardia cancer were diagnosed. 196 cases were randomly sampled from them and formed the case group. 185 subjects were randomly sampled from the subcohort, which was built up in a previous case-cohort study and was able to represent the baseline population, forming the control group. Serum samples were assayed for H. pylori IgG antibodies by enzyme-linked immunosorbent assay. The adjusted odds ratio (OR) and 95% confidence interval (95% CI) were calculated for cardia cancer, and also calculated by time from blood collection, time to diagnosis, gender and age, when blood was taken.

RESULTS

The positive rate of H. pylori IgG antibodies in control and case groups was 71.4% and 82.1%, respectively. The adjusted OR (95% CI) were 2.00 (1.21-3.31) for all cardia cancer cases, 1.36 (0.71-2.60) for male subjects, and 4.19 (1.73-10.17) for female subjects. By age group when blood samples were collected, the adjusted OR (95% CI) were 3.45 (1.41-8.45), 1.56 (0.69-3.54) and 1.11 (0.37-3.33) for < or = 50, 51-60 and > 60-years-old groups, respectively. The adjusted OR (95% CI) were 1.78 (0.88-3.60), 1.66 (0.80-3.44) and 2.23 (1.05-4.74) for cases diagnosed < or = 5, 6-10 and > 10 years after blood collection, respectively.

CONCLUSION

H. pylori infection is associated with gastric cardia cancer, especially for female subjects, the ones who were younger than 50 years old and who were infected with H. pylori more than 10 years.

Authors+Show Affiliations

Department of Cancer Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100021, China.

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

19024516

Citation

Ren, Jian-song, and You-lin Qiao. "[Helicobacter Pylori Infection and Gastric Cardia Cancer: a Nested Case-control Study]." Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology], vol. 30, no. 6, 2008, pp. 428-31.
Ren JS, Qiao YL. [Helicobacter pylori infection and gastric cardia cancer: a nested case-control study]. Zhonghua Zhong Liu Za Zhi. 2008;30(6):428-31.
Ren, J. S., & Qiao, Y. L. (2008). [Helicobacter pylori infection and gastric cardia cancer: a nested case-control study]. Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology], 30(6), pp. 428-31.
Ren JS, Qiao YL. [Helicobacter Pylori Infection and Gastric Cardia Cancer: a Nested Case-control Study]. Zhonghua Zhong Liu Za Zhi. 2008;30(6):428-31. PubMed PMID: 19024516.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Helicobacter pylori infection and gastric cardia cancer: a nested case-control study]. AU - Ren,Jian-song, AU - Qiao,You-lin, PY - 2008/11/26/pubmed PY - 2010/3/31/medline PY - 2008/11/26/entrez SP - 428 EP - 31 JF - Zhonghua zhong liu za zhi [Chinese journal of oncology] JO - Zhonghua Zhong Liu Za Zhi VL - 30 IS - 6 N2 - OBJECTIVE: To explore the association of Helicobacter pylori infection with gastric cardia cancer. METHODS: An unmatched prospective nested case-control study was conducted. In 1985, 29 584 subjects in age of 40-69 were recruited from Linxian, Henan Province. 10 mL blood samples were collected from all participants. By March 2001, 1089 cases of gastric cardia cancer were diagnosed. 196 cases were randomly sampled from them and formed the case group. 185 subjects were randomly sampled from the subcohort, which was built up in a previous case-cohort study and was able to represent the baseline population, forming the control group. Serum samples were assayed for H. pylori IgG antibodies by enzyme-linked immunosorbent assay. The adjusted odds ratio (OR) and 95% confidence interval (95% CI) were calculated for cardia cancer, and also calculated by time from blood collection, time to diagnosis, gender and age, when blood was taken. RESULTS: The positive rate of H. pylori IgG antibodies in control and case groups was 71.4% and 82.1%, respectively. The adjusted OR (95% CI) were 2.00 (1.21-3.31) for all cardia cancer cases, 1.36 (0.71-2.60) for male subjects, and 4.19 (1.73-10.17) for female subjects. By age group when blood samples were collected, the adjusted OR (95% CI) were 3.45 (1.41-8.45), 1.56 (0.69-3.54) and 1.11 (0.37-3.33) for < or = 50, 51-60 and > 60-years-old groups, respectively. The adjusted OR (95% CI) were 1.78 (0.88-3.60), 1.66 (0.80-3.44) and 2.23 (1.05-4.74) for cases diagnosed < or = 5, 6-10 and > 10 years after blood collection, respectively. CONCLUSION: H. pylori infection is associated with gastric cardia cancer, especially for female subjects, the ones who were younger than 50 years old and who were infected with H. pylori more than 10 years. SN - 0253-3766 UR - https://www.unboundmedicine.com/medline/citation/19024516/[Helicobacter_pylori_infection_and_gastric_cardia_cancer:_a_nested_case_control_study]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0253-3766&amp;year=2008&amp;vol=30&amp;issue=6&amp;fpage=428 DB - PRIME DP - Unbound Medicine ER -