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Anhedonia as a phenotype for the Val158Met COMT polymorphism in relatives of patients with schizophrenia.
J Abnorm Psychol. 2008 Nov; 117(4):788-98.JA

Abstract

The Val(158)Met polymorphism of the catechol-O-methyltransferase (COMT) gene has been associated with aspects of schizophrenia that are possibly related to the disorder's pathogenesis. The present study investigated the Val(158)Met polymorphism in relation to anhedonia--a construct central to negative schizotypy. Anhedonia and other schizotypal characteristics were assessed in relatives of patients with schizophrenia, relatives of patients with bipolar disorder, and nonpsychiatric controls using the Chapman schizotypy scales and the Schizotypal Personality Questionnaire. Compared with controls, relatives of individuals with schizophrenia had elevated scores on Chapman scales for social anhedonia and physical anhedonia, while relatives of patients with bipolar disorder exhibited only increased scores on the Social Anhedonia Scale. As a group, relatives of patients with schizophrenia who were homozygous for the val allele of the COMT polymorphism showed the highest elevations in self-reported social and physical anhedonia. Associations with the COMT polymorphism were absent in relatives of patients with bipolar disorder and control participants. Findings suggest that anhedonia is manifest in individuals who carry genetic liability for schizophrenia and is associated with the Val(158)Met polymorphism of the COMT gene.

Authors+Show Affiliations

Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19025226

Citation

Docherty, Anna R., and Scott R. Sponheim. "Anhedonia as a Phenotype for the Val158Met COMT Polymorphism in Relatives of Patients With Schizophrenia." Journal of Abnormal Psychology, vol. 117, no. 4, 2008, pp. 788-98.
Docherty AR, Sponheim SR. Anhedonia as a phenotype for the Val158Met COMT polymorphism in relatives of patients with schizophrenia. J Abnorm Psychol. 2008;117(4):788-98.
Docherty, A. R., & Sponheim, S. R. (2008). Anhedonia as a phenotype for the Val158Met COMT polymorphism in relatives of patients with schizophrenia. Journal of Abnormal Psychology, 117(4), 788-98. https://doi.org/10.1037/a0013745
Docherty AR, Sponheim SR. Anhedonia as a Phenotype for the Val158Met COMT Polymorphism in Relatives of Patients With Schizophrenia. J Abnorm Psychol. 2008;117(4):788-98. PubMed PMID: 19025226.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anhedonia as a phenotype for the Val158Met COMT polymorphism in relatives of patients with schizophrenia. AU - Docherty,Anna R, AU - Sponheim,Scott R, PY - 2008/11/26/pubmed PY - 2009/1/14/medline PY - 2008/11/26/entrez SP - 788 EP - 98 JF - Journal of abnormal psychology JO - J Abnorm Psychol VL - 117 IS - 4 N2 - The Val(158)Met polymorphism of the catechol-O-methyltransferase (COMT) gene has been associated with aspects of schizophrenia that are possibly related to the disorder's pathogenesis. The present study investigated the Val(158)Met polymorphism in relation to anhedonia--a construct central to negative schizotypy. Anhedonia and other schizotypal characteristics were assessed in relatives of patients with schizophrenia, relatives of patients with bipolar disorder, and nonpsychiatric controls using the Chapman schizotypy scales and the Schizotypal Personality Questionnaire. Compared with controls, relatives of individuals with schizophrenia had elevated scores on Chapman scales for social anhedonia and physical anhedonia, while relatives of patients with bipolar disorder exhibited only increased scores on the Social Anhedonia Scale. As a group, relatives of patients with schizophrenia who were homozygous for the val allele of the COMT polymorphism showed the highest elevations in self-reported social and physical anhedonia. Associations with the COMT polymorphism were absent in relatives of patients with bipolar disorder and control participants. Findings suggest that anhedonia is manifest in individuals who carry genetic liability for schizophrenia and is associated with the Val(158)Met polymorphism of the COMT gene. SN - 0021-843X UR - https://www.unboundmedicine.com/medline/citation/19025226/Anhedonia_as_a_phenotype_for_the_Val158Met_COMT_polymorphism_in_relatives_of_patients_with_schizophrenia_ L2 - http://content.apa.org/journals/abn/117/4/788 DB - PRIME DP - Unbound Medicine ER -