Tags

Type your tag names separated by a space and hit enter

Grasping behavior in schizophrenia suggests selective impairment in the dorsal visual pathway.
J Abnorm Psychol. 2008 Nov; 117(4):799-811.JA

Abstract

This study frames anomalous functional brain organization in schizophrenia (SCZ) within an evolutionary model of brain development, the dual trends theory (DTT). The DTT argues that neural architecture develops along 2 separate pathways: the dorsal archicortical trend and the ventral paleocortical trend. The DTT dovetails with visual system organization, which is also composed of 2 independent pathways: a dorsal stream dedicated to visuomotor action and a ventral stream dedicated to perceptual processing. The present study examined the integrity of these pathways using a size-contrast visual illusion. Prior research has shown that, normally, perceptual estimations of object size are susceptible to visual illusions, whereas goal-directed actions are resistant. The authors hypothesized that, unlike control participants, SCZ patients' actions would be susceptible to the illusion, reflecting dorsal stream dysfunction. Here, 42 SCZ patients and 42 healthy controls grasped and estimated the size of target blocks in control and illusion conditions. During estimation, both groups were equally perturbed by the illusion; however, grasping movements of patients alone were influenced by the illusion. These results suggest disrupted dorsal brain circuitry in SCZ but relatively intact ventral circuitry.

Authors+Show Affiliations

St. Joseph's Healthcare Hamilton, 100 West 5th Street, Hamilton, Ontario, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19025227

Citation

King, Jelena P., et al. "Grasping Behavior in Schizophrenia Suggests Selective Impairment in the Dorsal Visual Pathway." Journal of Abnormal Psychology, vol. 117, no. 4, 2008, pp. 799-811.
King JP, Christensen BK, Westwood DA. Grasping behavior in schizophrenia suggests selective impairment in the dorsal visual pathway. J Abnorm Psychol. 2008;117(4):799-811.
King, J. P., Christensen, B. K., & Westwood, D. A. (2008). Grasping behavior in schizophrenia suggests selective impairment in the dorsal visual pathway. Journal of Abnormal Psychology, 117(4), 799-811. https://doi.org/10.1037/a0013500
King JP, Christensen BK, Westwood DA. Grasping Behavior in Schizophrenia Suggests Selective Impairment in the Dorsal Visual Pathway. J Abnorm Psychol. 2008;117(4):799-811. PubMed PMID: 19025227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Grasping behavior in schizophrenia suggests selective impairment in the dorsal visual pathway. AU - King,Jelena P, AU - Christensen,Bruce K, AU - Westwood,David A, PY - 2008/11/26/pubmed PY - 2009/1/14/medline PY - 2008/11/26/entrez SP - 799 EP - 811 JF - Journal of abnormal psychology JO - J Abnorm Psychol VL - 117 IS - 4 N2 - This study frames anomalous functional brain organization in schizophrenia (SCZ) within an evolutionary model of brain development, the dual trends theory (DTT). The DTT argues that neural architecture develops along 2 separate pathways: the dorsal archicortical trend and the ventral paleocortical trend. The DTT dovetails with visual system organization, which is also composed of 2 independent pathways: a dorsal stream dedicated to visuomotor action and a ventral stream dedicated to perceptual processing. The present study examined the integrity of these pathways using a size-contrast visual illusion. Prior research has shown that, normally, perceptual estimations of object size are susceptible to visual illusions, whereas goal-directed actions are resistant. The authors hypothesized that, unlike control participants, SCZ patients' actions would be susceptible to the illusion, reflecting dorsal stream dysfunction. Here, 42 SCZ patients and 42 healthy controls grasped and estimated the size of target blocks in control and illusion conditions. During estimation, both groups were equally perturbed by the illusion; however, grasping movements of patients alone were influenced by the illusion. These results suggest disrupted dorsal brain circuitry in SCZ but relatively intact ventral circuitry. SN - 0021-843X UR - https://www.unboundmedicine.com/medline/citation/19025227/Grasping_behavior_in_schizophrenia_suggests_selective_impairment_in_the_dorsal_visual_pathway_ L2 - http://content.apa.org/journals/abn/117/4/799 DB - PRIME DP - Unbound Medicine ER -