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Are cortical spreading depression and headache in migraine causally linked?
Cephalalgia 2009; 29(2):244-9C

Abstract

During the past few decades, much controversy has surrounded the pathophysiology of migraine. Cortical spreading depression (CSD) is widely accepted as the neuronal process underlying visual auras. It has been proposed that CSD can also cause the headaches, at least in migraine with aura. We describe three patients, each fulfilling the International Headache Society criteria for migraine with aura, who suffered from headaches 6-10 days per month. Two patients were treated with flunarizine and the third patient with topiramate for the duration of 4 months. All patients reported that aura symptoms resolved completely, whereas the migraine headache attacks persisted or even increased. These observations question the theory that CSD (silent or not) is a prerequisite for migraine headaches.

Authors+Show Affiliations

Department of Neurology, University of Hamburg, Hamburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

19025548

Citation

Wolthausen, J, et al. "Are Cortical Spreading Depression and Headache in Migraine Causally Linked?" Cephalalgia : an International Journal of Headache, vol. 29, no. 2, 2009, pp. 244-9.
Wolthausen J, Sternberg S, Gerloff C, et al. Are cortical spreading depression and headache in migraine causally linked? Cephalalgia. 2009;29(2):244-9.
Wolthausen, J., Sternberg, S., Gerloff, C., & May, A. (2009). Are cortical spreading depression and headache in migraine causally linked? Cephalalgia : an International Journal of Headache, 29(2), pp. 244-9. doi:10.1111/j.1468-2982.2008.01713.x.
Wolthausen J, et al. Are Cortical Spreading Depression and Headache in Migraine Causally Linked. Cephalalgia. 2009;29(2):244-9. PubMed PMID: 19025548.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Are cortical spreading depression and headache in migraine causally linked? AU - Wolthausen,J, AU - Sternberg,S, AU - Gerloff,C, AU - May,A, Y1 - 2008/11/18/ PY - 2008/11/26/pubmed PY - 2009/2/27/medline PY - 2008/11/26/entrez SP - 244 EP - 9 JF - Cephalalgia : an international journal of headache JO - Cephalalgia VL - 29 IS - 2 N2 - During the past few decades, much controversy has surrounded the pathophysiology of migraine. Cortical spreading depression (CSD) is widely accepted as the neuronal process underlying visual auras. It has been proposed that CSD can also cause the headaches, at least in migraine with aura. We describe three patients, each fulfilling the International Headache Society criteria for migraine with aura, who suffered from headaches 6-10 days per month. Two patients were treated with flunarizine and the third patient with topiramate for the duration of 4 months. All patients reported that aura symptoms resolved completely, whereas the migraine headache attacks persisted or even increased. These observations question the theory that CSD (silent or not) is a prerequisite for migraine headaches. SN - 1468-2982 UR - https://www.unboundmedicine.com/medline/citation/19025548/Are_cortical_spreading_depression_and_headache_in_migraine_causally_linked L2 - http://journals.sagepub.com/doi/full/10.1111/j.1468-2982.2008.01713.x?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -