Tags

Type your tag names separated by a space and hit enter

Efficacy and safety of ezetimibe added on to atorvastatin (20 mg) versus uptitration of atorvastatin (to 40 mg) in hypercholesterolemic patients at moderately high risk for coronary heart disease.
Am J Cardiol. 2008 Dec 01; 102(11):1489-94.AJ

Abstract

The aim of this study was to evaluate the efficacy and safety of ezetimibe 10 mg added to atorvastatin 20 mg compared with doubling atorvastatin to 40 mg in patients with hypercholesterolemia at moderately high risk for coronary heart disease who did not reach low-density lipoprotein (LDL) cholesterol levels <100 mg/dl with atorvastatin 20 mg. In this 6-week, multicenter, double-blind, randomized, parallel-group study, 196 patients treated with atorvastatin 20 mg received atorvastatin 20 mg plus ezetimibe 10 mg or atorvastatin 40 mg for 6 weeks. Adding ezetimibe 10 mg to atorvastatin 20 mg produced significantly greater reductions in LDL cholesterol than increasing atorvastatin to 40 mg (-31% vs -11%, p <0.001). Significantly greater reductions were also seen in non-high-density lipoprotein cholesterol, total cholesterol, and apolipoprotein B (p <0.001). Significantly more patients reached LDL cholesterol levels <100 mg/dl with atorvastatin 20 mg plus ezetimibe compared with atorvastatin 40 mg (84% vs 49%, p <0.001). The 2 treatment groups had comparable results for high-density lipoprotein cholesterol, triglycerides, apolipoprotein A-I, and high-sensitivity C-reactive protein. The incidences of clinical and laboratory adverse experiences were generally similar between groups. In conclusion, the addition of ezetimibe 10 mg to atorvastatin 20 mg was generally well tolerated and resulted in significantly greater lipid-lowering efficacy compared with doubling atorvastatin to 40 mg in patients with hypercholesterolemia at moderately high risk for coronary heart disease.

Authors+Show Affiliations

University of Texas Southwestern Medical School, Dallas, TX, USA. sconard@med-edge.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19026302

Citation

Conard, Scott E., et al. "Efficacy and Safety of Ezetimibe Added On to Atorvastatin (20 Mg) Versus Uptitration of Atorvastatin (to 40 Mg) in Hypercholesterolemic Patients at Moderately High Risk for Coronary Heart Disease." The American Journal of Cardiology, vol. 102, no. 11, 2008, pp. 1489-94.
Conard SE, Bays HE, Leiter LA, et al. Efficacy and safety of ezetimibe added on to atorvastatin (20 mg) versus uptitration of atorvastatin (to 40 mg) in hypercholesterolemic patients at moderately high risk for coronary heart disease. Am J Cardiol. 2008;102(11):1489-94.
Conard, S. E., Bays, H. E., Leiter, L. A., Bird, S. R., Rubino, J., Lowe, R. S., Tomassini, J. E., & Tershakovec, A. M. (2008). Efficacy and safety of ezetimibe added on to atorvastatin (20 mg) versus uptitration of atorvastatin (to 40 mg) in hypercholesterolemic patients at moderately high risk for coronary heart disease. The American Journal of Cardiology, 102(11), 1489-94. https://doi.org/10.1016/j.amjcard.2008.09.075
Conard SE, et al. Efficacy and Safety of Ezetimibe Added On to Atorvastatin (20 Mg) Versus Uptitration of Atorvastatin (to 40 Mg) in Hypercholesterolemic Patients at Moderately High Risk for Coronary Heart Disease. Am J Cardiol. 2008 Dec 1;102(11):1489-94. PubMed PMID: 19026302.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy and safety of ezetimibe added on to atorvastatin (20 mg) versus uptitration of atorvastatin (to 40 mg) in hypercholesterolemic patients at moderately high risk for coronary heart disease. AU - Conard,Scott E, AU - Bays,Harold E, AU - Leiter,Lawrence A, AU - Bird,Steven R, AU - Rubino,Joseph, AU - Lowe,Robert S, AU - Tomassini,Joanne E, AU - Tershakovec,Andrew M, Y1 - 2008/10/23/ PY - 2008/09/09/received PY - 2008/09/29/revised PY - 2008/09/29/accepted PY - 2008/11/26/pubmed PY - 2008/12/23/medline PY - 2008/11/26/entrez SP - 1489 EP - 94 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 102 IS - 11 N2 - The aim of this study was to evaluate the efficacy and safety of ezetimibe 10 mg added to atorvastatin 20 mg compared with doubling atorvastatin to 40 mg in patients with hypercholesterolemia at moderately high risk for coronary heart disease who did not reach low-density lipoprotein (LDL) cholesterol levels <100 mg/dl with atorvastatin 20 mg. In this 6-week, multicenter, double-blind, randomized, parallel-group study, 196 patients treated with atorvastatin 20 mg received atorvastatin 20 mg plus ezetimibe 10 mg or atorvastatin 40 mg for 6 weeks. Adding ezetimibe 10 mg to atorvastatin 20 mg produced significantly greater reductions in LDL cholesterol than increasing atorvastatin to 40 mg (-31% vs -11%, p <0.001). Significantly greater reductions were also seen in non-high-density lipoprotein cholesterol, total cholesterol, and apolipoprotein B (p <0.001). Significantly more patients reached LDL cholesterol levels <100 mg/dl with atorvastatin 20 mg plus ezetimibe compared with atorvastatin 40 mg (84% vs 49%, p <0.001). The 2 treatment groups had comparable results for high-density lipoprotein cholesterol, triglycerides, apolipoprotein A-I, and high-sensitivity C-reactive protein. The incidences of clinical and laboratory adverse experiences were generally similar between groups. In conclusion, the addition of ezetimibe 10 mg to atorvastatin 20 mg was generally well tolerated and resulted in significantly greater lipid-lowering efficacy compared with doubling atorvastatin to 40 mg in patients with hypercholesterolemia at moderately high risk for coronary heart disease. SN - 1879-1913 UR - https://www.unboundmedicine.com/medline/citation/19026302/Efficacy_and_safety_of_ezetimibe_added_on_to_atorvastatin__20_mg__versus_uptitration_of_atorvastatin__to_40_mg__in_hypercholesterolemic_patients_at_moderately_high_risk_for_coronary_heart_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(08)01669-X DB - PRIME DP - Unbound Medicine ER -