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Caffeinated coffee consumption, cardiovascular disease, and heart valve disease in the elderly (from the Framingham Study).
Am J Cardiol. 2008 Dec 01; 102(11):1502-8.AJ

Abstract

The relation between caffeinated coffee consumption and heart disease morbidity and mortality is of great interest given the extensive use of this beverage. A recent prospective epidemiologic study found a strong protective association in elderly subjects without moderate to severe hypertension in the NHANES. To test this association in the Framingham Heart Study population, in which cardiovascular risk factors and health behaviors were carefully documented, Cox regression analyses were conducted for 1,354 subjects aged 65.4 to 96.6 years at study entry. There were 210 deaths from cardiovascular disease and 118 from coronary heart disease (CHD) during 10.1 years of follow-up. A significant negative association between caffeinated coffee consumption and CHD mortality was observed for subjects with systolic blood pressure (BP) <160 mm Hg and diastolic BP <100 mm Hg. The decrease in risk of CHD mortality for any caffeinated coffee versus none was 43% (95% confidence interval 9 to 64). This decreased risk appeared to be caused primarily by an inverse prospective relation between caffeinated coffee consumption and the development or progression of heart valve disease. The decrease in risk of heart valve disease for subjects with systolic BP <160 mm Hg and diastolic BP <100 mm Hg for any caffeinated coffee versus none was 43% (95% confidence interval 4 to 66). In conclusion, caffeinated coffee consumption was associated with lower risk of CHD mortality and heart valve disease development or progression in older Framingham subjects without moderate or severe hypertension.

Authors+Show Affiliations

Department of Health and Nutrition Sciences, Brooklyn College of the City University of New York, Brooklyn, NY, USA. jamesg@brooklyn.cuny.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19026304

Citation

Greenberg, James A., et al. "Caffeinated Coffee Consumption, Cardiovascular Disease, and Heart Valve Disease in the Elderly (from the Framingham Study)." The American Journal of Cardiology, vol. 102, no. 11, 2008, pp. 1502-8.
Greenberg JA, Chow G, Ziegelstein RC. Caffeinated coffee consumption, cardiovascular disease, and heart valve disease in the elderly (from the Framingham Study). Am J Cardiol. 2008;102(11):1502-8.
Greenberg, J. A., Chow, G., & Ziegelstein, R. C. (2008). Caffeinated coffee consumption, cardiovascular disease, and heart valve disease in the elderly (from the Framingham Study). The American Journal of Cardiology, 102(11), 1502-8. https://doi.org/10.1016/j.amjcard.2008.07.046
Greenberg JA, Chow G, Ziegelstein RC. Caffeinated Coffee Consumption, Cardiovascular Disease, and Heart Valve Disease in the Elderly (from the Framingham Study). Am J Cardiol. 2008 Dec 1;102(11):1502-8. PubMed PMID: 19026304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Caffeinated coffee consumption, cardiovascular disease, and heart valve disease in the elderly (from the Framingham Study). AU - Greenberg,James A, AU - Chow,Grant, AU - Ziegelstein,Roy C, Y1 - 2008/09/11/ PY - 2008/06/02/received PY - 2008/07/19/revised PY - 2008/07/19/accepted PY - 2008/11/26/pubmed PY - 2008/12/23/medline PY - 2008/11/26/entrez SP - 1502 EP - 8 JF - The American journal of cardiology JO - Am J Cardiol VL - 102 IS - 11 N2 - The relation between caffeinated coffee consumption and heart disease morbidity and mortality is of great interest given the extensive use of this beverage. A recent prospective epidemiologic study found a strong protective association in elderly subjects without moderate to severe hypertension in the NHANES. To test this association in the Framingham Heart Study population, in which cardiovascular risk factors and health behaviors were carefully documented, Cox regression analyses were conducted for 1,354 subjects aged 65.4 to 96.6 years at study entry. There were 210 deaths from cardiovascular disease and 118 from coronary heart disease (CHD) during 10.1 years of follow-up. A significant negative association between caffeinated coffee consumption and CHD mortality was observed for subjects with systolic blood pressure (BP) <160 mm Hg and diastolic BP <100 mm Hg. The decrease in risk of CHD mortality for any caffeinated coffee versus none was 43% (95% confidence interval 9 to 64). This decreased risk appeared to be caused primarily by an inverse prospective relation between caffeinated coffee consumption and the development or progression of heart valve disease. The decrease in risk of heart valve disease for subjects with systolic BP <160 mm Hg and diastolic BP <100 mm Hg for any caffeinated coffee versus none was 43% (95% confidence interval 4 to 66). In conclusion, caffeinated coffee consumption was associated with lower risk of CHD mortality and heart valve disease development or progression in older Framingham subjects without moderate or severe hypertension. SN - 1879-1913 UR - https://www.unboundmedicine.com/medline/citation/19026304/Caffeinated_coffee_consumption_cardiovascular_disease_and_heart_valve_disease_in_the_elderly__from_the_Framingham_Study__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(08)01271-X DB - PRIME DP - Unbound Medicine ER -