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Neurotropin reverses paclitaxel-induced neuropathy without affecting anti-tumour efficacy.
Eur J Cancer. 2009 Jan; 45(1):154-63.EJ

Abstract

Paclitaxel is a commonly used anticancer drug, but it frequently causes peripheral neuropathy. Neurotropin, a non-protein extract from inflamed rabbit skin inoculated with vaccinia virus, has been used to treat various chronic painful conditions. In the present study, we investigated the effect of neurotropin on the paclitaxel-induced neuropathy in rats. Repeated administration of paclitaxel induced mechanical allodynia, cold hyperalgesia, and motor dysfunction. These neuropathies were mostly reversed by the repeated administration of neurotropin. Furthermore, neurotropin ameliorated the paclitaxel-induced axonal degeneration in cultured PC12 and rat dorsal root ganglion cells, and in rat sciatic nerve. In addition, neurotropin did not affect the microtubule aggregation or anti-tumour effect induced by paclitaxel in the tumour cell lines or tumour cells-implanted mice. These results suggest that neurotropin reverses the paclitaxel-induced neuropathy without affecting anti-tumour activity of paclitaxel, and therefore may be useful for the paclitaxel-induced neuropathy in clinical settings.

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Authors+Show Affiliations

Kawashiri T
Department of Pharmacy, Kyushu University Hospital, Higashi-ku, Fukuoka, Japan.
Egashira N
No affiliation info available
Itoh Y
No affiliation info available
Shimazoe T
No affiliation info available
Ikegami Y
No affiliation info available
Yano T
No affiliation info available
Yoshimura M
No affiliation info available
Oishi R
No affiliation info available

MeSH

Adjuvants, ImmunologicAnimalsAntineoplastic Agents, PhytogenicAxonsCell Line, TumorCold TemperatureHyperalgesiaMaleMiceMice, Inbred C57BLMotor ActivityNeoplasm TransplantationNeuritesPaclitaxelPeripheral Nervous System DiseasesPolysaccharidesRatsRats, Sprague-Dawley

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19027286

Citation

Kawashiri, Takehiro, et al. "Neurotropin Reverses Paclitaxel-induced Neuropathy Without Affecting Anti-tumour Efficacy." European Journal of Cancer (Oxford, England : 1990), vol. 45, no. 1, 2009, pp. 154-63.
Kawashiri T, Egashira N, Itoh Y, et al. Neurotropin reverses paclitaxel-induced neuropathy without affecting anti-tumour efficacy. Eur J Cancer. 2009;45(1):154-63.
Kawashiri, T., Egashira, N., Itoh, Y., Shimazoe, T., Ikegami, Y., Yano, T., Yoshimura, M., & Oishi, R. (2009). Neurotropin reverses paclitaxel-induced neuropathy without affecting anti-tumour efficacy. European Journal of Cancer (Oxford, England : 1990), 45(1), 154-63. https://doi.org/10.1016/j.ejca.2008.10.004
Kawashiri T, et al. Neurotropin Reverses Paclitaxel-induced Neuropathy Without Affecting Anti-tumour Efficacy. Eur J Cancer. 2009;45(1):154-63. PubMed PMID: 19027286.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurotropin reverses paclitaxel-induced neuropathy without affecting anti-tumour efficacy. AU - Kawashiri,Takehiro, AU - Egashira,Nobuaki, AU - Itoh,Yoshinori, AU - Shimazoe,Takao, AU - Ikegami,Yoko, AU - Yano,Takahisa, AU - Yoshimura,Megumu, AU - Oishi,Ryozo, Y1 - 2008/11/20/ PY - 2008/05/02/received PY - 2008/09/26/revised PY - 2008/10/06/accepted PY - 2008/11/26/pubmed PY - 2009/1/29/medline PY - 2008/11/26/entrez SP - 154 EP - 63 JF - European journal of cancer (Oxford, England : 1990) JO - Eur J Cancer VL - 45 IS - 1 N2 - Paclitaxel is a commonly used anticancer drug, but it frequently causes peripheral neuropathy. Neurotropin, a non-protein extract from inflamed rabbit skin inoculated with vaccinia virus, has been used to treat various chronic painful conditions. In the present study, we investigated the effect of neurotropin on the paclitaxel-induced neuropathy in rats. Repeated administration of paclitaxel induced mechanical allodynia, cold hyperalgesia, and motor dysfunction. These neuropathies were mostly reversed by the repeated administration of neurotropin. Furthermore, neurotropin ameliorated the paclitaxel-induced axonal degeneration in cultured PC12 and rat dorsal root ganglion cells, and in rat sciatic nerve. In addition, neurotropin did not affect the microtubule aggregation or anti-tumour effect induced by paclitaxel in the tumour cell lines or tumour cells-implanted mice. These results suggest that neurotropin reverses the paclitaxel-induced neuropathy without affecting anti-tumour activity of paclitaxel, and therefore may be useful for the paclitaxel-induced neuropathy in clinical settings. SN - 1879-0852 UR - https://www.unboundmedicine.com/medline/citation/19027286/Neurotropin_reverses_paclitaxel_induced_neuropathy_without_affecting_anti_tumour_efficacy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0959-8049(08)00803-4 DB - PRIME DP - Unbound Medicine ER -