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Low vitamin K intakes in community-dwelling elders at an early stage of Alzheimer's disease.
J Am Diet Assoc. 2008 Dec; 108(12):2095-9.JA

Abstract

An increasing body of evidence points to a role for vitamin K in brain physiology through its participation in sphingolipid metabolism and biological activation of the vitamin K-dependent protein Gas6. One hypothesis is that vitamin K may also play a role in the pathogenesis of Alzheimer's disease. A recent study found that patients with early-stage Alzheimer's disease consumed less vitamin K than did cognitively intact control subjects. To learn more about the dietary intakes and food sources of vitamin K in these patients, a detailed analysis was conducted. Dietary vitamin K intakes were assessed from 5 nonconsecutive days of food records collected from 31 community-dwelling patients with early-stage Alzheimer's disease and in 31 age- and sex-matched cognitively intact control subjects. Mean vitamin K intake on a person-day basis was 63+/-90 microg/day in patients and 139+/-233 microg/day in control subjects. Vitamin K intakes were significantly less in participants with Alzheimer's disease (P<0.0001), even after adjusting for energy intakes (P=0.0003). Vegetables, fats, and fruits contributed more than 70% of total vitamin K intake in both groups. The main source of vitamin K was green vegetables, which contributed 33% and 49% to total intakes in patients and control subjects, respectively. This lower consumption of green vegetables in participants with Alzheimer's disease explained their lower vitamin K intakes overall. Despite their limitations, results are in line with the most recent research in both vitamin K and Alzheimer's disease and suggest a need to consider vitamin K in future investigations on the role of diet in Alzheimer's disease.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Presse N
Département de Nutrition, Université de Montréal, Montréal, Canada.
Shatenstein B
No affiliation info available
Kergoat MJ
No affiliation info available
Ferland G
No affiliation info available

MeSH

AgedAgingAlzheimer DiseaseCase-Control StudiesDietDiet RecordsFemaleFood AnalysisHumansMaleNutritional RequirementsNutritional StatusVegetablesVitamin K

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19027415

Citation

Presse, Nancy, et al. "Low Vitamin K Intakes in Community-dwelling Elders at an Early Stage of Alzheimer's Disease." Journal of the American Dietetic Association, vol. 108, no. 12, 2008, pp. 2095-9.
Presse N, Shatenstein B, Kergoat MJ, et al. Low vitamin K intakes in community-dwelling elders at an early stage of Alzheimer's disease. J Am Diet Assoc. 2008;108(12):2095-9.
Presse, N., Shatenstein, B., Kergoat, M. J., & Ferland, G. (2008). Low vitamin K intakes in community-dwelling elders at an early stage of Alzheimer's disease. Journal of the American Dietetic Association, 108(12), 2095-9. https://doi.org/10.1016/j.jada.2008.09.013
Presse N, et al. Low Vitamin K Intakes in Community-dwelling Elders at an Early Stage of Alzheimer's Disease. J Am Diet Assoc. 2008;108(12):2095-9. PubMed PMID: 19027415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low vitamin K intakes in community-dwelling elders at an early stage of Alzheimer's disease. AU - Presse,Nancy, AU - Shatenstein,Bryna, AU - Kergoat,Marie-Jeanne, AU - Ferland,Guylaine, PY - 2008/01/22/received PY - 2008/05/23/accepted PY - 2008/11/26/pubmed PY - 2009/1/30/medline PY - 2008/11/26/entrez SP - 2095 EP - 9 JF - Journal of the American Dietetic Association JO - J Am Diet Assoc VL - 108 IS - 12 N2 - An increasing body of evidence points to a role for vitamin K in brain physiology through its participation in sphingolipid metabolism and biological activation of the vitamin K-dependent protein Gas6. One hypothesis is that vitamin K may also play a role in the pathogenesis of Alzheimer's disease. A recent study found that patients with early-stage Alzheimer's disease consumed less vitamin K than did cognitively intact control subjects. To learn more about the dietary intakes and food sources of vitamin K in these patients, a detailed analysis was conducted. Dietary vitamin K intakes were assessed from 5 nonconsecutive days of food records collected from 31 community-dwelling patients with early-stage Alzheimer's disease and in 31 age- and sex-matched cognitively intact control subjects. Mean vitamin K intake on a person-day basis was 63+/-90 microg/day in patients and 139+/-233 microg/day in control subjects. Vitamin K intakes were significantly less in participants with Alzheimer's disease (P<0.0001), even after adjusting for energy intakes (P=0.0003). Vegetables, fats, and fruits contributed more than 70% of total vitamin K intake in both groups. The main source of vitamin K was green vegetables, which contributed 33% and 49% to total intakes in patients and control subjects, respectively. This lower consumption of green vegetables in participants with Alzheimer's disease explained their lower vitamin K intakes overall. Despite their limitations, results are in line with the most recent research in both vitamin K and Alzheimer's disease and suggest a need to consider vitamin K in future investigations on the role of diet in Alzheimer's disease. SN - 0002-8223 UR - https://www.unboundmedicine.com/medline/citation/19027415/Low_vitamin_K_intakes_in_community_dwelling_elders_at_an_early_stage_of_Alzheimer's_disease_ DB - PRIME DP - Unbound Medicine ER -