Tags

Type your tag names separated by a space and hit enter

Hospitalization risk associated with typical and atypical antipsychotic use in community-dwelling elderly patients.
Am J Geriatr Pharmacother. 2008 Oct; 6(4):198-204.AJ

Abstract

BACKGROUND

Due to age-related changes in drug disposition and response, elderly patients are more susceptible to the adverse effects of antipsychotic medications than younger adults. However, few studies have examined the impact of typical and atypical antipsychotic use on all-cause hospitalization in the elderly population.

OBJECTIVE

This study compared the short-term effects of incident use of typical and atypical antipsychotic agents on the risk for hospitalization in a community-dwelling elderly population.

METHODS

This retrospective data analysis involved a longitudinal cohort of typical and atypical antipsychotic users and was based on data from the 1996-2004 Medical Expenditure Panel Survey. Typical antipsychotic agents included chlorpromazine, fluphenazine, haloperidol, levomepromazine, loxapine, mesoridazine, molindone, perphenazine, promazine, thioridazine, thiothixene, and trifluoperazine. Atypical antipsychotic agents included aripiprazole, clozapine, olanzapine, quetiapine, risperidone, and ziprasidone. Incident cases of antipsychotic use in community-dwelling elderly (aged > or =60 years) persons were selected for the assessment of risk for all-cause hospitalization within 60 days of exposure to antipsychotics. Bivariate analyses were used to compare baseline characteristics; multivariate logistic regression was used to compare hospitalization risk among users of typicals and atypicals after controlling for age, sex, race, income, insurance coverage, perceived general health, perceived mental health, and other concurrent psychotropic use.

RESULTS

The analytical sample consisted of 124 community-dwelling elderly patients (atypicals, 75 patients; typicals, 49). A majority of the elderly study sample were women (63%), white (79%), and of middle/high income (57%). The mean (SD) age of the study sample was 74.37 (8.65) years. There were no significant differences in baseline characteristics between typical and atypical users, with the exception of perceived mental health status. After controlling for other factors, the risk for hospitalization was nearly 4-fold higher with typical antipsychotic use than atypical use (odds ratio, 3.81; 95% CI, 1.12-12.99).

CONCLUSION

In this population of community-dwelling elderly, use of typical agents was associated with an increased risk for hospitalization compared with atypical agents.

Authors+Show Affiliations

Department of Clinical Sciences and Administration, College of Pharmacy, University of Houston, Texas Medical Center, Houston, Texas 77030, USA. rraparasu@uh.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19028375

Citation

Aparasu, Rajender R., et al. "Hospitalization Risk Associated With Typical and Atypical Antipsychotic Use in Community-dwelling Elderly Patients." The American Journal of Geriatric Pharmacotherapy, vol. 6, no. 4, 2008, pp. 198-204.
Aparasu RR, Jano E, Johnson ML, et al. Hospitalization risk associated with typical and atypical antipsychotic use in community-dwelling elderly patients. Am J Geriatr Pharmacother. 2008;6(4):198-204.
Aparasu, R. R., Jano, E., Johnson, M. L., & Chen, H. (2008). Hospitalization risk associated with typical and atypical antipsychotic use in community-dwelling elderly patients. The American Journal of Geriatric Pharmacotherapy, 6(4), 198-204. https://doi.org/10.1016/j.amjopharm.2008.10.003
Aparasu RR, et al. Hospitalization Risk Associated With Typical and Atypical Antipsychotic Use in Community-dwelling Elderly Patients. Am J Geriatr Pharmacother. 2008;6(4):198-204. PubMed PMID: 19028375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hospitalization risk associated with typical and atypical antipsychotic use in community-dwelling elderly patients. AU - Aparasu,Rajender R, AU - Jano,Elda, AU - Johnson,Michael L, AU - Chen,Hua, PY - 2008/07/14/accepted PY - 2008/11/26/pubmed PY - 2009/1/23/medline PY - 2008/11/26/entrez SP - 198 EP - 204 JF - The American journal of geriatric pharmacotherapy JO - Am J Geriatr Pharmacother VL - 6 IS - 4 N2 - BACKGROUND: Due to age-related changes in drug disposition and response, elderly patients are more susceptible to the adverse effects of antipsychotic medications than younger adults. However, few studies have examined the impact of typical and atypical antipsychotic use on all-cause hospitalization in the elderly population. OBJECTIVE: This study compared the short-term effects of incident use of typical and atypical antipsychotic agents on the risk for hospitalization in a community-dwelling elderly population. METHODS: This retrospective data analysis involved a longitudinal cohort of typical and atypical antipsychotic users and was based on data from the 1996-2004 Medical Expenditure Panel Survey. Typical antipsychotic agents included chlorpromazine, fluphenazine, haloperidol, levomepromazine, loxapine, mesoridazine, molindone, perphenazine, promazine, thioridazine, thiothixene, and trifluoperazine. Atypical antipsychotic agents included aripiprazole, clozapine, olanzapine, quetiapine, risperidone, and ziprasidone. Incident cases of antipsychotic use in community-dwelling elderly (aged > or =60 years) persons were selected for the assessment of risk for all-cause hospitalization within 60 days of exposure to antipsychotics. Bivariate analyses were used to compare baseline characteristics; multivariate logistic regression was used to compare hospitalization risk among users of typicals and atypicals after controlling for age, sex, race, income, insurance coverage, perceived general health, perceived mental health, and other concurrent psychotropic use. RESULTS: The analytical sample consisted of 124 community-dwelling elderly patients (atypicals, 75 patients; typicals, 49). A majority of the elderly study sample were women (63%), white (79%), and of middle/high income (57%). The mean (SD) age of the study sample was 74.37 (8.65) years. There were no significant differences in baseline characteristics between typical and atypical users, with the exception of perceived mental health status. After controlling for other factors, the risk for hospitalization was nearly 4-fold higher with typical antipsychotic use than atypical use (odds ratio, 3.81; 95% CI, 1.12-12.99). CONCLUSION: In this population of community-dwelling elderly, use of typical agents was associated with an increased risk for hospitalization compared with atypical agents. SN - 1543-5946 UR - https://www.unboundmedicine.com/medline/citation/19028375/Hospitalization_risk_associated_with_typical_and_atypical_antipsychotic_use_in_community_dwelling_elderly_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1543-5946(08)00055-X DB - PRIME DP - Unbound Medicine ER -