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Serum retinol-binding protein 4 levels in nonobese women with polycystic ovary syndrome.
Fertil Steril. 2010 Feb; 93(3):869-73.FS

Abstract

OBJECTIVE

To test whether there was a difference in serum retinol-binding protein 4 (RBP4) levels between subjects with polycystic ovary syndrome (PCOS) and those with a healthy regular menstrual cycle and, in addition, to correlate serum RBP4 levels with a variety of parameters.

DESIGN

Clinical study.

SETTING

University hospital.

PATIENT(S)

A total of 74 nonobese women were evaluated. Thirty-seven had PCOS, whereas the remaining 37 served as control subjects.

INTERVENTION(S)

Serum RBP4 levels were analyzed using ELISA.

MAIN OUTCOME MEASURE(S)

Serum levels of FSH, LH, TSH, E(2), T, insulin, glucose, cholesterol, triglycerides, and RBP4.

RESULT(S)

The women with PCOS had higher levels of serum RBP4, waist-to-hip ratio, LH, T, insulin, homeostatic model assessment of insulin resistance, cholesterol, and triglycerides. Logistic regression analyses revealed a significant association between odds ratio (OR) values of PCOS and both T (OR = 1.125; 95% confidence interval [CI] 1.050-1.205), and cholesterol levels (OR = 1.029; 95% CI 1.004-1.056). Age and triglycerides were significantly correlated to serum RBP4 levels by multiple linear regression analysis.

CONCLUSION(S)

Our study has shown that [1] elevated RBP4 levels might arise from triglyceride metabolism, and that RBP4 levels might not be influenced by PCOS itself. [2] RBP4 might not be a useful marker of insulin resistance in subjects with PCOS.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19028383

Citation

Chan, Te-Fu, et al. "Serum Retinol-binding Protein 4 Levels in Nonobese Women With Polycystic Ovary Syndrome." Fertility and Sterility, vol. 93, no. 3, 2010, pp. 869-73.
Chan TF, Tsai YC, Chiu PR, et al. Serum retinol-binding protein 4 levels in nonobese women with polycystic ovary syndrome. Fertil Steril. 2010;93(3):869-73.
Chan, T. F., Tsai, Y. C., Chiu, P. R., Chen, Y. L., Lee, C. H., & Tsai, E. M. (2010). Serum retinol-binding protein 4 levels in nonobese women with polycystic ovary syndrome. Fertility and Sterility, 93(3), 869-73. https://doi.org/10.1016/j.fertnstert.2008.10.039
Chan TF, et al. Serum Retinol-binding Protein 4 Levels in Nonobese Women With Polycystic Ovary Syndrome. Fertil Steril. 2010;93(3):869-73. PubMed PMID: 19028383.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum retinol-binding protein 4 levels in nonobese women with polycystic ovary syndrome. AU - Chan,Te-Fu, AU - Tsai,Yung-Chieh, AU - Chiu,Pu-Rong, AU - Chen,Yi-Ling, AU - Lee,Chien-Hung, AU - Tsai,Eing-Mei, Y1 - 2008/11/25/ PY - 2008/08/30/received PY - 2008/10/16/revised PY - 2008/10/17/accepted PY - 2008/11/26/pubmed PY - 2010/3/17/medline PY - 2008/11/26/entrez SP - 869 EP - 73 JF - Fertility and sterility JO - Fertil Steril VL - 93 IS - 3 N2 - OBJECTIVE: To test whether there was a difference in serum retinol-binding protein 4 (RBP4) levels between subjects with polycystic ovary syndrome (PCOS) and those with a healthy regular menstrual cycle and, in addition, to correlate serum RBP4 levels with a variety of parameters. DESIGN: Clinical study. SETTING: University hospital. PATIENT(S): A total of 74 nonobese women were evaluated. Thirty-seven had PCOS, whereas the remaining 37 served as control subjects. INTERVENTION(S): Serum RBP4 levels were analyzed using ELISA. MAIN OUTCOME MEASURE(S): Serum levels of FSH, LH, TSH, E(2), T, insulin, glucose, cholesterol, triglycerides, and RBP4. RESULT(S): The women with PCOS had higher levels of serum RBP4, waist-to-hip ratio, LH, T, insulin, homeostatic model assessment of insulin resistance, cholesterol, and triglycerides. Logistic regression analyses revealed a significant association between odds ratio (OR) values of PCOS and both T (OR = 1.125; 95% confidence interval [CI] 1.050-1.205), and cholesterol levels (OR = 1.029; 95% CI 1.004-1.056). Age and triglycerides were significantly correlated to serum RBP4 levels by multiple linear regression analysis. CONCLUSION(S): Our study has shown that [1] elevated RBP4 levels might arise from triglyceride metabolism, and that RBP4 levels might not be influenced by PCOS itself. [2] RBP4 might not be a useful marker of insulin resistance in subjects with PCOS. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/19028383/Serum_retinol_binding_protein_4_levels_in_nonobese_women_with_polycystic_ovary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(08)04265-9 DB - PRIME DP - Unbound Medicine ER -